Browsing by Author "Atici, Emine"

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Both Hypothyroidism and Hyperthyroidism Increase Plasma Irisin Levels in Rats
(2018) Atici, Emine; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, Esma; https://orcid.org/0000-0002-6547-4798; 29182513; AAL-5444-2020
Background: A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim: The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods: The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3. Hypothyroidism (PTU 2 weeks) + L-thyroxin (1.5 mg/kg/day for 1 week); 4. Hyperthyroidism induced in rats by 3-week thyroxin (0.3 mg/kg/day); 5. Hyperthyroidism + PTU. At the end of the study, blood samples were collected to quantify free triiodothyronine (FT3), free triiodothyronine (FT4) and irisin levels. Results: FT3 and FT4 levels were reduced in hypothyroidism and were significantly elevated in hyperthyroidism (p < 0.001). Irisin values, on the other hand, were found to be elevated in both hypothyroidism and hyperthyroidism groups (p < 0.001). Conclusion: The results of the study suggest that irisin values increase in thyroid dysfunction, hypo-and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal.
The Effect of Thyroid Dysfunction on Nesfatin-1 And Adiponectin Levels in Rats
(2017) Atici, Emine; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, Esma; 0000-0003-2461-1212; 0000-0002-5477-5667; 0000-0002-6547-4798; 28796641; AAL-5444-2020; ABA-7831-2020; AAG-5865-2019
Background: Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim: The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods: The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1.5 mg/kg/day) for 1 week]; (4) hyperthyroidism [hyperthyroidism was induced by 3-weeks' thyroxine injection (0.3 mg/kg/day)]; (5) hyperthyroidism + PTU (after hyperthyroidism was induced by 2-weeks' thyroxine injection, the animals were given 10 mg/kg/day PTU for 1 week). Blood samples taken at the end of the study were analyzed to measure nesfatin-1 and adiponectin levels. Results: It was found that nesfatin-1 levels increased in hypothyroidism, while adiponectin levels decreased (p < 0.001). In experimental hyperthyroidism, on the other hand, both nesfatin-1 and adiponectin levels were found significantly elevated (p < 0.001). Conclusion: The results of the study indicate that nesfatin-1 and adiponectin levels were modified considerably in hypo- and hyperthyroidism, whereas with the restoration of the thyroid function, modified hormone levels went back to normal.
The Effects of Instrument-Assisted Soft Tissue Mobilization and Kinesio Taping on Pain, Functional Disability and Depression in Patients with Chronic Low Back Pain: A Randomized Trial
(2022) Cakmak, Ozge; Atici, Emine; Gulsen, Mustafa
Purpose: Low back pain is a common condition that can become chronic, which reduces the life quality of the patient by causing functional disability and depression. This study aimed to investigate the effects of instrument-assisted soft tissue mobilization (IASTM) and kinesio taping (KT) along with conservative treatment in patients with chronic nonspecific low back pain (CNLBP). Methods: A total of 30 patients with chronic low back pain aged between 30-50 years included in the study were randomized to IASTM (n=15) and KT (n=15) groups. Both the groups underwent conservative treatment that comprised of a hot pack, ultrasound, transcutaneous electrical nerve stimulation (TENS) and home exercises. In this study, assessments were made using the Visual Analogue Scale (VAS), Roland Morris Disability Questionnaire (RMDQ), and Beck Depression Inventory (BDI). The measurements were carried out at the beginning and end of the treatment. Results: As a result of the study, IASTM method improved in parameters such as pain (p<0.05), functionality (p=0.001) and depression (p<0.05). As a result of the study, the KT group improved in parameters such as pain, functionality and depression compared to pre-treatment (p<0.05). However, the two treatments were not superior to each other in pain (p=0.241), functionality (p=0.687) and depression (p=0.699) parameters. Conclusion: It has been observed that both treatments have positive effects on many parameters such as pain, disability, depression and mental state in patients with CNLBP. This study demonstrates that IASTM and KT treatments can be used to support therapeutic effects in patients with CNLBP.
EFFECTS OF KINESIO TAPING ON POSTURAL STABILITY IN YOUNG SOCCER PLAYERS
(2019) Gulsen, Mustafa; Pekyavas, Niahn Ozunlu; Atici, Emine; Sahin, Fatma Nese; Guler, Ozkan
Background: This study aims to investigate the effects of Kinesio Taping on postural stability in young soccer players. Methods: 62 volunteer soccer players from Cayyolu Sports Club were included in our study. Players were randomly allocated into two groups; a Kinesio taping (KT) (n=31), and a control group (n = 31). KT application including gastrocnemius and quadriceps femoris muscle facilitation techniques were applied to the first group. The second group was set as the control group and no application was made. Sociodemographic characteristics, postural stability and thermographic assessment were evaluated prior to and after the application of the Kinesio Taping. All the statistical analyses were set a priori at an alpha level of p<0.05. The tests for homogeneity (Levene's test) and normality (Shapiro-Wilk) were used to determine the appropriate statistical methods to apply for comparison between the groups. According to the test results, the parametric paired sample T-test was used to compare between baseline and post-treatment within a group, while independent sample T-test for equality of means was used for comparison between the groups. Results: No statistically significant differences were observed between the groups at baseline regarding age, body mass index, skin temperature and postural stability (p > 0.05). Statistically significant differences were found in all the assessed parameters in both Kinesio Taping and control groups (all p<0.05) except thermal imaging of dominant gastrocnemius muscle results (p=0.668) after the Kinesio application. Statistically significant differences were found in all parameters across groups (all p<0.05). Conclusions: Kinesio Taping may increase postural stability and decrease the risk of injury. According to thermal imaging assessments, both quadriceps and gastrocnemius muscles may be active in maintaining postural stability. As the decreasing risk of injury is very important for young soccer players, our results may show a preventive measure for sports physiotherapists working on soccer fields.
Effects of Traction Therapy in Addition to Conventional Physiotherapy Modalities on Pain and Functionality in Patients with Lumbar Disc Herniation: Randomized Controlled Study
(2018) Gulsen, Mustafa; Atici, Emine; Aytar, Aydan; Sahin, Fatma Nese; HIR-3735-2022
The aim of this study is to investigate the effects of traction therapy in addition to conventional physiotherapy modalities on pain and functionality in patients with chronic lumbar disc herniation. Patients (n=210, mean age=48.20 +/- 13.07 years, mean height=167.2 +/- 9.34 and mean weight= 74.86 +/- 13.47) were diagnosed with lumbar disc hernia through a clinical evaluation and an MRI and were graded as "protrusion or bulging lumbar herniation" according to the Macnab Classification. Patients were then randomly divided into 3 groups: the first group (n=70) underwent a hot pack (HP), Transcutaneous Electrical Nerve Stimulation (TENS), ultrasounds (US) and home exercise (HE); the second group (n=75) underwent additional traction therapy compared to the first group and the third group (n=65) was given only home exercise. Sociodemographic and clinical characteristics of patients were recorded. All assessments were done before and after the treatments (4th week). Pain and functional status of patients were evaluated. There were no significant differences between the groups (p>0.05) except for pain score (p<0.05). Comparing within groups showed improvements in all parameters after treatment (p<0.05). Although there was a significant difference between group 1 and group 3, group 2 and group 3 in pain scores (p< 0.05), there was no significant difference found for other outcome measures.It was observed that in all treatment groups, there was a significant reduction of pain and functional impairment. Traction therapy wasn't more effective than other treatments for patients with lumbar disc herniation. As a clinical outcome not only physiotherapy modalities are effective, but also specific home exercises could be considered as a form of treatment for patients with lumbar disc hernia.