Browsing by Author "Ataman, Sebnem"

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    Anti-Tumor Necrosis Factor Alpha Treatment Does Not Influence Serum Levels of the Markers Associated with Radiographic Progression in Ankylosing Spondylitis
    (2023) Ozdemirel, Ali Erhan; Guven, Serdar Can; Doganci, Alper; Surmeli, Zuhre Sari; Ozyuvali, Ayla; Kurt, Mehmet; Rustemova, Diana; Hassan, Selin; Sayin, Ayse Peyman Yalcin; Tutkak, Huseyin; Ataman, Sebnem; 37235120
    Objectives: The study aimed to determine the levels of change of the markers related to radiographic progression, such as Dickkopf-1 (DKK-1), sclerostin (SOST), bone morphogenetic protein (BMP)-2 and -4, and interleukin (IL)-17 and -23, in ankylosing spondyloarthritis (AS) during anti-tumor necrosis factor alpha (TNF-alpha) treatment. Patients and methods: Fifty-three anti-TNF-alpha naive AS patients (34 males, 19 females; median: 38 years; range, 20 to 52 years) refractory to conventional treatments meeting the modified New York criteria or Assessment of SpondyloArthritis International Society classification criteria were enrolled to this cross-sectional, controlled study between October 2015 and January 2017. Fifty healthy volunteers (35 males, 15 females; median: 36 years; range, 18 to 55 years) with similar age and sex characteristics were recruited. Serum DKK-1, BMP-2, BMP-4, SOST, IL-17, and IL-23 levels were measured in both groups. The serum levels of the markers were measured again after about two years (mean follow-up duration of 21.7 +/- 6.4 months) in AS patients who started anti-TNF-alpha treatment. Demographic, clinical characteristics, and laboratory parameters were recorded. The disease activity at the time of inclusion was assessed through the Bath Ankylosing Spondylitis Disease Activity Index. Results: Serum DKK-1, SOST, IL-17, and IL-23 levels in the AS group before anti-TNF-alpha treatment were significantly higher compared to the control group (p<0.01 for DKK-1, p<0.001 for others). There was no difference regarding serum BMP-4 levels, whereas BMP-2 levels were significantly higher in the control group (p<0.01). Forty (75.47%) AS patients had serum marker levels measured after anti-TNF-alpha treatment. No significant change was observed in the serum levels of these 40 patients measured 21.7 +/- 6.4 months after the initiation of anti-TNF-alpha treatment (p>0.05 for all). Conclusion: In AS patients, there was no change in DKK-1/SOST, BMP, and IL-17/23 cascade with anti-TNF-alpha treatment. This finding may suggest that these pathways act independently of each other, and their local effects are not influenced by systemic inflammation.
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    Ultrasonographic Evaluation of Achilles Tendon in Early Axial Spondyloarthropathy: Is There Any Difference between Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthropathy?
    (2018) Vahidfar, Shahla; Sunar, Ismihan; Ataman, Sebnem; Yilmaz, Gurkan; Azarabadi, Javid M.; Bolukbasi, Ayse; 0000-0002-4435-5677; 0000-0003-3570-3825; AAB-7763-2019; AAA-2977-2020
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    Ultrasonographic evaluation of Achilles tendon: Is there any difference between ankylosing spondylitis, non-radiographic axial spondyloarthropathy and controls?
    (2020) Vahidfar, Shahla; Sunar, Ismihan; Ataman, Sebnem; Yilmaz, Gurkan; Azarabadi, Javid M.; Bolukbasi, Ayse; 31985181
    Purpose: The aim is to evaluate Achilles tendon enthesopathy with ultrasound (US) in ankylosing spondylitis (AS) and non-radiographic axial SpA (nr-axSpA) patients and controls, and compare these groups in terms of associations between disease activity parameters and ultrasonographic Achilles enthesitis signs. Methods: A total of 24 AS and 20 nr-axSpA patients fulfilling the Assessment in Spondyloarthritis International Working Group criteria for axSpA and 30 controls were enrolled. Demographic characteristics, erythrocyte sedimentation rate, C-reactive protein (CRP), human leukocyte antigen (HLA)-B27, Bath AS Disease Activity Index, Bath AS Functional Index, Bath AS Metrology Index, Maastricht AS Enthesitis Score (MASES), AS Disease Activity Score-CRP, modified Stoke AS Spine Score (m-SASSS) scores and ultrasonographic findings were noted. Results: HLA-B27 positivity, extra-articular and peripheral involvement, disease activity, functional status, mean m-SASSS, ultrasonographic gray scale (GS) and total scores were similar between AS and nr-axSpA groups. In GS, tendon echotexture scores were significantly different across all groups (0.812 +/- 0.384 in AS, 0.575 +/- 0.466 in nr-axSpA, 0.017 +/- 0.091 in controls; P < .001). Entheseal calcification scores were similar in AS and nr-axSpA patients, and higher than controls (P = .001). Bone profile scores were similar in patients with AS and nr-axSpA, and higher than controls (P = .010). When the correlations between US findings and disease activity and functional status were considered, power Doppler US (PDUS) and MASES total scores were positively correlated in the AS group (P = .045; r = .41). Conclusion: AS and nr-axSpA patients were found to be similar in various clinical, functional, and US findings indicating that these 2 entities are different phenotypic reflections of the same disease spectrum. The positive correlation between PDUS and MASES scores in AS patients substantiate the performance of MASES in evaluation of entheseal activity.