Browsing by Author "Asuroglu, Tunc"

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A deep learning approach for sepsis monitoring via severity score estimation
(2021) Asuroglu, Tunc; Ogul, Hasan; 33157471
Background and objective: Sepsis occurs in response to an infection in the body and can progress to a fatal stage. Detection and monitoring of sepsis require multi-step analysis, which is time-consuming, costly and requires medically trained personnel. A metric called Sequential Organ Failure Assessment (SOFA) score is used to determine the severity of sepsis. This score depends heavily on laboratory measurements. In this study, we offer a computational solution for quantitatively monitoring sepsis symptoms and organ systems state without laboratory test. To this end, we propose to employ a regression-based analysis by using only seven vital signs that can be acquired from bedside in Intensive Care Unit (ICU) to predict the exact value of SOFA score of patients before sepsis occurrence. Methods: A model called Deep SOFA-Sepsis Prediction Algorithm (DSPA) is introduced. In this model, we combined Convolutional Neural Networks (CNN) features with Random Forest (RF) algorithm to predict SOFA scores of sepsis patients. A subset of Medical Information Mart in Intensive Care (MIMIC) III dataset is used in experiments. 5154 samples are extracted as input. Ten-fold cross validation test are carried out for experiments. Results: We demonstrated that our model has achieved a Correlation Coefficient (CC) of 0.863, a Mean Absolute Error (MAE) of 0.659, a Root Mean Square Error (RMSE) of 1.23 for predictions at sepsis onset. The accuracies of SOFA score predictions for 6 hours before sepsis onset were 0.842, 0.697, and 1.308, in terms of CC, MAE and RMSE, respectively. Our model outperformed traditional machine learning and deep learning models in regression analysis. We also evaluated our model's prediction performance for identifying sepsis patients in a binary classification setup. Our model achieved up to 0.982 AUC (Area Under Curve) for sepsis onset and 0.972 AUC for 6 hours before sepsis, which are higher than those reported by previous studies. Conclusions: By utilizing SOFA scores, our framework facilitates the prognose of sepsis and infected organ systems state. While previous studies focused only on predicting presence of sepsis, our model aims at providing a prognosis solution for sepsis. SOFA score estimation process in ICU depends on laboratory environment. This dependence causes delays in treating patients, which in turn may increase the risk of complications. By using easily accessible non-invasive vital signs that are routinely collected in ICU, our framework can eliminate this delay. We believe that the estimation of the SOFA score will also help health professionals to monitor organ states. (C) 2020 Elsevier B.V. All rights reserved.
Information Retrieval in Metal Music Sub Genres
(2017) Acici, Koray; Asuroglu, Tunc; Ogul, Hasan; 0000-0003-4153-0764; HDM-9910-2022; AAC-7834-2020
Digital music platforms use meta-data based information retrieval systems for offering songs to users for their own taste of music. According to this system, songs that are labeled by other users are compared to songs that user listened and similar labeled songs are retrived in the process. In this situtation, information retrieval is independent from song content and subjective. To achieve objectivity, content based information retrieval systems are needed. In this study, a content-based music retrieval system based on one dimensional local binary pattern features which are extracted from audio data is proposed. Instead of retrieving different music genres, retrieval is applied on metal music sub-genres which have not been studied before and results are reported.
On computer-aided prognosis of septic shock from vital signs
(2019) Ogul, Hasan; Baldominos, Alejandro; Asuroglu, Tunc; Colomo-Palacios, Ricardo; AAC-7834-2020
Sepsis is a life-threatening condition due to the reaction to an infection. With certain changes in circulatory system, sepsis may progress to septic shock if it is left untreated. Therefore, early prognosis of septic shock may facilitate implementing correct treatment and prevent more serious complications. In this study, we assess the feasibility of applying a computer-aided prognosis system for septic shock. The system is envisaged as a tool to predict septic shock at the time of sepsis onset using only vital signs which are collected routinely in intensive care units (ICUs). To this end, we evaluate the performances of computational methods that take the sequence of vital signs acquired until sepsis onset as input and report the possibility of progressing to a septic shock before any further clinical analysis is performed. Results show that an adaptation of multivariate dynamic time warping can reveal higher accuracy than other known time-series classification methods on a new dataset built from a public ICU database. We argue that the use of computational intelligence methods can promote computer-aided prognosis of septic shock in hospitalized environment to a certain degree.
Parkinson's Disease Monitoring from Gait Analysis via Foot-Worn Sensors
(2018) Asuroglu, Tunc; Acici, Koray; Erdas, Cagatay Berke; Toprak, Munire Kilinc; Erdem, Hamit; Ogul, Hasan; https://orcid.org/0000-0002-3821-6419; https://orcid.org/0000-0001-7979-0276; AAC-7834-2020; HDM-9910-2022; AAJ-8674-2021
Background: In Parkinson's disease (PD), neuronal loss in the substantia nigra ultimate in dopaminergic denervation of the stiratum is followed by disarraying of the movements' preciseness, automatism, and agility. Hence, the seminal sign of PD is a change in motor performance of affected individuals. As PD is a neurodegenerative disease, progression of disability in mobility is an inevitable consequence. Indeed, the major cause of morbidity and mortality among patients with PD is the motor changes restricting their functional independence. Therefore, monitoring the manifestations of the disease is crucial to detect any worsening of symptoms timely, in order to maintain and improve the quality of life of these patients. Aim: The changes in motion of patients with PD can be ascertained by the help of wearable sensors attached to the limbs of subjects. Then analysing the recorded data for variation of signals would make it possible to figure an individualized profile of the disease. Advancement of such tools would improve understanding of the disease evolution in the long term and simplify the detection of precipitous changes in gait on a daily basis in the short term. In both cases the apperception of such events would contribute to improve the clinical decision making process with reliable data. To this end, we offer here a computational solution for effective monitoring of PD patients from gait analysis via multiple foot-worn sensors. Methods: We introduce a supervised model that is fed by ground reaction force (GRF) signals acquired from these gait sensors. We offer a hybrid model, called Locally Weighted Random Forest (LWRF), for regression analysis over the numerical features extracted from input signals to predict the severity of PD symptoms in terms of Universal Parkinson Disease Rating Scale (UPDRS) and Hoehn and Yahr (H&Y) scale. From GRF signals sixteen time-domain features and seven frequency-domain features were extracted and used. Results and conclusion: An experimental analysis conducted on a real data acquired from PD patients and healthy controls has shown that the predictions are highly correlated with the clinical annotations. Proposed approach for severity detection has the best correlation coefficient (CC), mean absolute error (MAE) and root mean squared error (RMSE) values with 0.895, 4.462 and 7.382 respectively in terms of UPDRS. The regression results for H&Y Scale discerns that proposed model outperforms other models with CC, MAE and RMSE with values 0.960, 0.168 and 0.306 respectively. In classification setup, proposed approach achieves higher accuracy in comparison with other studies with accuracy and specificity of 99.0% and 99.5% respectively. Main novelty of this approach is the fact that an exact value of the symptom level can be inferred rather than a categorical result that defines the severity of motor disorders. (C) 2018 Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.
Performance Analysis of Spatial and Frequency Domain Filtering In High Resolution Images
(2015) Asuroglu, Tunc; Sumer, Emre; 0000-0003-4153-0764; ITV-2441-2023; AGA-5711-2022
Predicting Infections Using Computational Intelligence - A Systematic Review
(2020) Baldominos, Alejandro; Puello, Adrian; Ogul, Hasan; Asuroglu, Tunc; Colomo-Palacios, Ricardo; 0000-0003-4153-0764
Infections encompass a set of medical conditions of very diverse kinds that can pose a significant risk to health, and even death. As with many other diseases, early diagnosis can help to provide patients with proper care to minimize the damage produced by the disease, or to isolate them to avoid the risk of spread. In this context, computational intelligence can be useful to predict the risk of infection in patients, raising early alarms that can aid medical teams to respond as quick as possible. In this paper, we survey the state of the art on infection prediction using computer science by means of a systematic literature review. The objective is to find papers where computational intelligence is used to predict infections in patients using physiological data as features. We have posed one major research question along with nine specific subquestions. The whole review process is thoroughly described, and eight databases are considered which index most of the literature published in different scholarly formats. A total of 101 relevant documents have been found in the period comprised between 2003 and 2019, and a detailed study of these documents is carried out to classify the works and answer the research questions posed, resulting to our best knowledge in the most comprehensive study of its kind. We conclude that the most widely addressed infection is by far sepsis, followed by Clostridium difficile infection and surgical site infections. Most works use machine learning techniques, from which logistic regression, support vector machines, random forest and naive Bayes are the most common. Some machine learning works provide some ideas on the problems of small data and class imbalance, which can be of interest. The current systematic literature review shows that automatic diagnosis of infectious diseases using computational intelligence is well documented in the medical literature.
A Random Forest Method to Detect Parkinson's Disease via Gait Analysis
(2017) Acici, Koray; Erdas, Cagatay Berke; Asuroglu, Tunc; Toprak, Munire Kilinc; Erdem, Hamit; Ogul, Hasan; 0000-0001-7979-0276; 0000-0003-4153-0764; 0000-0002-3821-6419; 0000-0003-3467-9923; AAJ-8674-2021; AAC-7834-2020; ITV-2441-2023; HDM-9910-2022
Remote care and telemonitoring have become essential component of current geriatric medicine. Intelligent use of wireless sensors is a major issue in relevant computational studies to realize these concepts in practice. While there has been a growing interest in recognizing daily activities of patients through wearable sensors, the efforts towards utilizing the streaming data from these sensors for clinical practices are limited. Here, we present a practical application of clinical data mining from wearable sensors with a particular objective of diagnosing Parkinson's Disease from gait analysis through a sets of ground reaction force (GRF) sensors worn under the foots. We introduce a supervised learning method based on Random Forests that analyze the multi-sensor data to classify the person wearing these sensors. We offer to extract a set of time-domain and frequency-domain features that would be effective in distinguishing normal and diseased people from their gait signals. The experimental results on a benchmark dataset have shown that proposed method can significantly outperform the previous methods reported in the literature.
Texture of Activities: Exploiting Local Binary Patterns for Accelerometer Data Analysis
(2016) Asuroglu, Tunc; Acici, Koray; Erdas, Cagatay Berke; Ogul, Hasan; 0000-0003-4153-0764; 0000-0002-3821-6419; 0000-0003-3467-9923; AAC-7834-2020; HDM-9910-2022
Recognition of activities through wearable sensors such as accelerometers is a recent challenge in pervasive and ubiquitous computing. The problem is often considered as a classification task where a set of descriptive features are extracted from input signal to feed a machine learning classifier. A major issue ignored so far in these studies is the incorporation of locally embedded features that could indeed be informative in describing the main activity performed by the individual being experimented. To close this gap, we offer here adapting Local Binary Pattern (LBP) approach, which is frequently used in identifying textures in images, in one-dimensional space of accelerometer data. To this end, we exploit the histogram of LPB found in each axes of input accelerometer signal as a feature set to feed a k-Nearest Neighbor classifier. The experiments on a benchmark dataset have shown that the proposed method can outperform some previous methods.