Browsing by Author "Asakuma, Mitsuhiro"

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    Hepatitis A Virus-related Late-onset Hepatic Failure: A Case Report
    (Başkent Üniversitesi, 2011-04) Hayashi, Michihiro; Tanigawa, Nobuhiko; Haga, Hironori; Takeshita, Atsushi; Asakuma, Mitsuhiro; Hirokawa, Fumitoshi; Tsunematsu, Ichiro; Shimizu, Tetsunosuke
    Late-onset hepatic failure, the least of the fulminant hepatic failures, has not occurred in patients with hepatitis A virus-related acute liver failure. We report a rare case of hepatitis A virus-related late-onset hepatic failure treated successfully by an emergent liver transplant. A 58-year-old Japanese woman who presented with fever and general malaise was diagnosed as having jaundice and liver dysfunction by a positive serum test for anti-hepatitis A virus IgM, which ultimately led to a diagnosis of acute hepatitis A virus-associated hepatitis. Despite intensive treatment, her general condition was poor, and she developed a hepatic coma 79 days from the onset of the disease. Under a diagnosis of hepatitis A virus-related late-onset hepatic failure, she was given a living-donor liver transplant 82 days from the start of the disease. The resected native liver revealed submassive necrosis with marked cholestasis, compatible with late-onset hepatic failure. Today, 5 years after the transplant, she is alive and well with no signs of recurrent hepatitis A virus-hepatitis. This case should alert the physician to the clinical management of a patient with hepatitis A virus-related acute liver failure.