Browsing by Author "Arslan, Ahmet"

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Evaluation of light-emitting diode photobiomodulation on bone healing of rat calvarial defects
(2015) Deniz, Ediz; Arslan, Ahmet; Diker, Nurettin; Olgac, Vakur; Kilic, Ertugrul
One of the major problems in modern dentistry is the recovery of bone defects. The aim of this prospective experimental study was to evaluate the effect of light-emitting diode (LED) photobiomodulation therapy on bone healing of rat calvarial defects. Twenty-eight male Sprague Dawley rats were used for the study. Critical size defects with 5 mm diameter were made with a trephine bur used in a low-speed handpiece under continuous sterile saline irrigation on each side of the sagittal suture. All critical size defects on the right side were filled with corticocancellous bone graft material and all the defects on the left side were left empty. The animals were randomly divided into two groups of 14 rats each. Group I received LED therapy and Group II did not receive any therapy. OsseoPulse (R) LED device (Biolux Research Ltd.) 618 nm wavelength and 20 mW/cm(2) output power irradiation was started immediately after the surgery and was applied for 20 minutes at 24-h intervals for 7 and 14 days. In each group, seven rats were sacrificed on the 8th day and the remaining rats were sacrificed on the 15th day. Bone healing of the non-grafted side was statistically significant in Group I on both 8th day and 15th day; on the other hand, in the grafted side, enhanced bone healing was dominantly observed on the 15th day in Group I, compared to Group II, although the difference was not significant. Within the limits of this study, the findings suggested that LED therapy might have a favourable effect in the early phase of bone healing.
Gene Mutations in Chronic Kidney Disease Patients With Secondary Hyperparathyroidism and Sagliker Syndrome
(2015) Demirhan, Osman; Arslan, Ahmet; Sagliker, Yahya; Akbal, Eylul; Ergun, Sercan; Bayraktar, Recep; Sagliker, Hasan Sabit; Dogan, Ekrem; Gunesacar, Ramazan; Ozkaynak, Piril Sagliker; 25701941
Sagliker syndrome (SS) develops particularly before pubertywhile chronic kidney disease (CKD) reaches stage 3 with overt secondary hyperparathyroidism. We conducted screening for mutations in all the 13 exons of GNAS1 gene, all 3 exons of FGF23, and all 18 exons in FGFR3 genes in 23 patients. In 73.9%(17 of 23) patients, 17 genetic abnormalities inGNAS1were detected. Seven (58.3%) of 12 nucleotide alterations comprised novel missense mutations and 3 nonsense. Mismutations were in different manner. There were also 6 heterozygous transversion polymorphisms in exons. Six were introngenicmutations (introns 65626, 70387, 70817). Wefound 10mutationswith differentmanner in FGF23 gene. Two were defined previously but remaining 8 were novel mutations. Threewere in intronic region near exon 2. We sequenced all exons and intronic regions near exon-exon junction regions ofFGFR3gene. Wefound 22mutations with differentmanner. Sixweredefinedpreviously and remaining 16 were novel mutations. Eight of them were in intronic region near exon 11 and the last 2 were in noncoding exonic region of exons. One was in the exon-exon junction region between exon 11 and 12, therefore this mutation might be preventing splicing of this intron. Because the incidence of CKD late stage 3 is around 8% but the incidence of SS is around 0.5% in CKD, these gene mismutations might be responsible for bone deformities such asMcCune-Albright syndrome and achondroplasias. Although our patients were not resembling any of them, they could be in between, and SS might be a combination-compulsion of bone dysplasias-hereditary osteodystrophies and CKD. (C) 2015 by the National Kidney Foundation, Inc. All rights reserved.
Multiple Gene Mutations in GNAS1, FGF23 AND FGFR3 Genes in CKD Patients with SH Sagliker Syndrome
(2016) Demirhan, Osman; Arslan, Ahmet; Sagliker, Yahya; Akbal, Eylul; Ergun, Sercan; Bayraktar, Recep; Sagliker, Hasan Sabit; Dogan, Ekrem; Gunesacar, Ramazan; Ozkaynak, Piril Sagliker; Paylar, Nuray
Novel Striking Mismutations on Gnas1, Fgf23 and Fgfr3 Genes in Ckd with Secondary Hyperparathyroidism (SH) And Sagliker Syndrome (SS). Ss Is Acombination-Compulsion of Bone Displasias-Hereditary Osteodystrophies and Ckd
(2015) Demirhan, Osman; Arslan, Ahmet; Sagliker, Yahya; Akbal, Eylul; Ergun, Sercan; Bayraktar, Recep; Sagliker, Hasan Sabit; Dogan, Ekrem; Gunesacar, Ramazan; Ozkaynak, Piril Sagliker; Paylar, Nuray