Browsing by Author "Anarat, Ali"

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Early Diabetic Nephropathy and Endothelial Dysfunction in Children with Type 1 Diabetes Mellitus
(2015) Aynaci, Sercan; Bayazit, Aysun K.; Melek, Engin; Gurbuz, Fatih; Atmis, Bahriye; Anarat, Ruksan; Yuksel, Bilgin; Anarat, Ali
Early Effects of Renal Replacement Therapy on Cardiovascular Comorbidity in Children With End-Stage Kidney Disease: Findings From the 4C-T Study
(2018) Schmidt, Bernhard M. W.; Sugianto, Rizky Indrameikha; Thurn, Daniela; Azukaitis, Karolis; Bayazit, Aysun K.; Canpolat, Nur; Eroglu, Ayse Guler; Caliskan, Salim; Doyon, Anke; Duzova, Ali; Karagoz, Tevfik; Anarat, Ali; Deveci, Murat; Mir, Sevgi; Ranchin, Bruno; Shroff, Rukshana; Baskin, Esra; Litwin, Mieczyslaw; Ozcakar, Z. Birsin; Buscher, Rainer; Soylemezoglu, Oguz; Dusek, Jiri; Kemper, Markus J.; Matteucci, Maria C.; Habbig, Sandra; Laube, Guido; Wuehl, Elke; Querfeld, Uwe; Sander, Anja; Schaefer, Franz; Melk, Anette; https://orcid.org/0000-0002-3316-8032; 28926375; B-5785-2018
Background The early impact of renal transplantation on subclinical cardiovascular measures in pediatric patients has not been widely investigated. This analysis is performed for pediatric patients participating in the prospective cardiovascular comorbidity in children with chronic kidney disease study and focuses on the early effects of renal replacement therapy (RRT) modality on cardiovascular comorbidity in patients receiving a preemptive transplant or started on dialysis. Methods We compared measures indicating subclinical cardiovascular organ damage (aortal pulse wave velocity, carotid intima media thickness, left ventricular mass index) and evaluated cardiovascular risk factors in 166 pediatric patients before and 6 to 18 months after start of RRT (n = 76 transplantation, n = 90 dialysis). Results RRT modality had a significant impact on the change in arterial structure and function: compared to dialysis treatment, transplantation was independently associated with decreases in pulse wave velocity (ss = -0.67; P < 0.001) and intima media thickness (ss = -0.40; P = 0.008). Independent of RRT modality, an increase in pulse wave velocity was associated with an increase in diastolic blood pressure (ss = 0.31; P < 0.001). Increasing intima media thickness was associated with a larger increase in body mass index (ss = 0.26; P = 0.003) and the use of antihypertensive agents after RRT (ss = 0.41; P = 0.007). Changes in left ventricular mass index were associated with changes in systolic blood pressure (ss = 1.47; P = 0.01). Conclusions In comparison with initiating dialysis, preemptive transplantation prevented further deterioration of the subclinical vascular organ damage early after transplantation. Classic cardiovascular risk factors, such as hypertension and obesity are of major importance for the development of cardiovascular organ damage after renal transplantation.
The effect of Ca-Dobesilate over renal scar formation in an experimental pyelonephritis model
(2020) Simsek, Behcet; Beyazit, Aysun Karabay; Gonlusen, Gulfiliz; Noyan, Aytul; Anarat, Ali
Purpose: This study was conducted to evaluate the effects of the drug: Ca-Dobesilate (CaD) which has been in common use in venous insufficiency treatment; on renal scarring and expressions of transforming growth factor beta1 (TGFb1), basic fibroblast growth factor (bFGF) and hepatocyte growth factor-beta (HGF-beta) in a rat pyelonephritis model. Materialw and Methods: Eight pyelonephritis groups, each constituting of 7 rats were developed as no treatment ciprofloxacin - ciprofloxacin and CaD administered groups; following injecting E Coli (ATCC 25922) into kidney. No treatment given rat groups were sacrificed following 24h, 72 h, 14d and 28d from bacterial seeding respectively. Rats from treatment groups were sacrificed after 14d and 28d accordingly. Diagnoses of pyelonephritis and fibrosis, TGFb, bFGF and HGF-beta were scored semiquantitatively by immunohistochemical staining. Results: The extent of pyelonephritis and fibrosis was lower in rats treated with ciprofloxacin and CaD compared to sole ciprofloxacin and no treatment administered counterparts among groups terminated after 2wks following bacterial inoculation. However, CaD effect on pyelonephritis and fibrosis scores did not persist after treatment was discontinued. Conclusion: CaD might alleviate pyelonephritis and scarring, depending on dosage and treatment period and further studies are needed to determine optimum treatment dose and duration.
Genotypic and Phenotypic Features of the Cystinosis Patients from the South Eastern Part of Turkey
(2016) Onenli-Mungan, Neslihan; Kor, Deniz; Karabay-Bayazit, Aysun; Cengiz, Nurcan; Yavuz, Sevgi; Noyan, Aytul; Ceylaner, Gulay; Seker Yilmaz, Berna; Topaloglu, Ali Kemal; Yuksel, Bilgin; Anarat, Ali; 28276207; GPX-7059-2022
We have conducted this study for the purposes of demonstrating the spectrum of mutations and of identifying their effects on the phenotype, with a particular focus on the clinical course, prognosis and response to treatment. A total of 25 patients from 20 families, who have been treated and followed up after being diagnosed with cystinosis. Nine patients were identified with mutations of homozygous c. 451A>G, 7 patients with homozygous c. 681G>A, 6 patients with homozygous c. 834_842del, 2 patients with homozygous c. 18_21delGACT and 1 patient with compound heterozygous for c. 451A>G/c. 1015G>A. The c. 834_842del mutation identified in six patients from four families has not been previously identified. Progression to renal failure occurred earlier in the patients identified with the new mutation, despite treatment. Larger patient series are required to demonstrate the genotypic properties of the patients with cystinosis and their relationship with the clinical course.
Response to Intensified Immunosuppressive Therapyand Identification of Genetic Disease are Highly Predictive of Long-Term Renal Outcome in Children with Steroid Resistant Nephrotic Syndrome (Srns)
(2015) Trautmann, Agnes; Schnaidt, Sven; Ghiggeri, Gian Marco; Ozaltin, Fatih; Saeed, Bassam; Drozdz, Dorota; Caliskan, Salim; Anarat, Ali; Oh, Jun; Bogdanovic, Radovan; Zurowska, Aleksandra; Balat, Ayse; Emre, Sevinc; Jardim, Helena; Kuzma-Mroczkowska, Elzbieta; Erdogan, Ozlem; Tkaczyk, Marcin; Krmar, Rafael T.; Higuita, Lina Maria Serna; Wasilewska, Anna; Baskin, Esra; Pasini, Andrea; Printza, Nikoleta; Firszt-Adamczyk, Agnieszka; Medynska, Anna; Schaefer, Franz; 0000-0003-4361-8508; B-5785-2018