Browsing by Author "Altinors, Dilek Dursun"

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Clinical outcomes of deep anterior lamellar keratoplasty (DALK) in keratoconus patients.
(2019) Altinors, Dilek Dursun; Asena, Leyla; Oto, Sibel
Clinical Outcomes of Scleral Misa Lenses for Visual Rehabilitation in Patients with Pellucid Marginal Degeneration
(2016) Asena, Leyla; Altinors, Dilek Dursun; 0000-0002-6848-203X; 0000-0001-5223-0279; 27432029; E-5914-2016; AAK-8077-2021
Purpose: To report the clinical outcomes of scleral Misa((R)) lenses (Microlens Contactlens Technolgy, Arnhem, Netherlands) for visual rehabilitation in patients with pellucid marginal degeneration (PMD). Mehods: In this prospective interventional case series, 24 eyes of 12 PMD patients were fitted with scleral Misa((R)) lenses. Patients were followed regularly for continuous daily wearing time (CDWT), contact lens handling issues, Visual acuity, and any subjective or objective contact lens related complications. Results: The mean patient age was 35.0 +/- 13.8 years (range, 23-47 years). The average length of follow-up was 14.1 +/- 3.7 months (range, 8.5-18 months). All eyes were fit with mini Misa((R)) scleral lenses with a diameter of 16.5 or 17 mm. The mean Snellen best-corrected visual acuity (BCVA) before scleral lenses with spectacle correction was 0.42 +/- 0.15 (range, 0.2-0.6). With scleral lenses, mean BCVA was 0.75 +/- 0.15 (range, 0.5-0.9), (p = 0.003) with a mean gain of 3.3 lines of BCVA. More than half (16 eyes, 67%) reported wearing theirscleral lenses for 8 h or more on a daily basis. Three patients (6 eyes, 25%) abandoned scleral lens wear. Patients who abandoned the scleral lens wear tended to have a better spectacle corrected visual acuity and less gain of lines. Conclusions: Scleral lenses can be used succesfully in patients with PMD who are intolerant to other types of contact lenses. Patients who have a low spectacle BCVA and a higher gain of visual acuity with scleral lenses are good candidates for scleral lens use. (C) 2016 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
Comparison of Keratometry Obtained by a Swept Source OCT-Based Biometer with a Standard Optical Biometer and Scheimpflug Imaging
(2018) Asena, Leyla; Akman, Ahmet; Gungor, Sirel Gur; Altinors, Dilek Dursun; 0000-0001-5223-0279; 0000-0002-6848-203X; 0000-0001-6178-8362; 29630418; AAK-8077-2021; E-5914-2016; AAD-5967-2021
Purpose: To assess agreement of a swept source-optical coherence tomography (SS-OCT) based Biometer with a standard IOLMaster device and Scheimpflug Imaging (SI) to acquire keratometric measurements in cataract patients. Methods: In this prospective comparative study, 101 eyes of 101 cataract surgery candidates, aged 24-81years, were sequentially examined using three devices. Keratometry values at the flat (K1) and steep (K2) axis, mean corneal power (Km) and magnitude of corneal astigmatism as well as J0 and J45 vectoral components of astigmatism obtained with the SS-OCT based biometer (IOLMaster 700) were compared with those obtained with the IOLMaster 500 and SI. The agreement between measurements was evaluated by the Bland-Altman method, intraclass correlation coefficients (ICCs) and repeated-measures analysis of variance. Results: Mean K1 values from the three devices were similar (p=0.09). Mean K2 and Km values of IOLMaster 700 were higher than SI and lower than IOLMaster 500 (p=0.04 for K2 and p=0.02 for Km). There was a strong correlation between K1, K2, Km and magnitude of astigmatism obtained with all devices (r >= 0.80 and p<0.01). The 95% limits of agreement (LoA) width for each keratometric value were highest for the comparison between IOLMaster 500 and SI and lowest for the comparison between IOLMaster 700 and 500. The mean differences (width of 95% LoA) for J0 and J45 vectoral components were 0.005 (2.19) and 0.12 (2.92) for the measurements obtained by IOLMaster 700 vs IOLMaster 500 and 0.06 (1.79) and 0.02 (1.58) for the measurements obtained by IOLMaster 700 vs SI, respectively. Conclusions: With ICCs close to 1, the agreement between all devices was excellent for keratometric measurements. Mean K2, Km and astigmatism measurements from IOLMaster 700 were lower than IOLMaster 500 and higher than SI. However, the differences were quite small and are not expected to affect the final IOL power.
Comparison of ocular discomfort after three different epithelial debridement techniques for corneal collagen cross-linking in keratoconus treatment
(2021) Alkayid, Hosamadden; Asena, Leyla; Yuce, Aslihan; Colak, Meric Yavuz; Altinors, Dilek Dursun; 34250443
Purpose: To compare the severity and duration of ocular discomfort after three different epithelial debridement techniques for corneal collagen cross-linking in the treatment of keratoconus. Methods: Fifty-five patients (65 eyes) known to have keratoconus were enrolled in this retrospective study. The eyes were divided into three groups based on the technique used for epithelial debridement for corneal collagen cross-linking procedure; excimer laser transepithelial phototherapeutic keratectomy was used in group 1 (18 eyes), alcohol-assisted epithelial removal was used in group 2 (27 eyes), and mechanical epithelial debridement was used in group 3 (20 eyes). Preoperative and postoperative (third month) best-corrected visual acuity (BCVA) using Snellen chart, objective refraction, and keratometry results were recorded. The results of the questionnaire obtained from the patient's medical records were reviewed regarding their subjective evaluation of postoperative symptoms including foreign body sensation, tearing, photophobia, and burning at the end of the first postoperative week. Paired-samples t test was used to compare preoperative and postoperative clinical findings. One-way analysis of variance (ANOVA) was used to analyze the differences between three independent groups. Results: BCVA improved from 0.51 +/- 0.27 to 0.58 +/- 0.21 (p = 0.05). Objective mean spherical and cylindrical refraction decreased from -5.08 +/- 2.78D to -4.46 +/- 2.91D (p = 0.22) and from -3.45 +/- 2.73D to -3.03 +/- 1.97D (p = 0.25). Mean maximum keratometry reading (K-max) decreased from 57.63 +/- 4.73D to 56.13 +/- 4.47D (p = 0.001). The mean score for foreign body sensation was the highest in group 3 (4.50 +/- 0.53) and the lowest in group 1 (2.10 +/- 1.85) (p = 0.01). The mean scores for tearing, photophobia, and burning sensation were comparable in three groups (p = 0.84, p = 0.13, and p = 0.61, respectively). The duration of photophobia was the shortest in group 1 (1.50 +/- 2.37 days), followed by group 3 (2.00 +/- 1.31 days) and group 2 (4.00 +/- 1.83 days) (p = 0.04). Conclusions: The severity and duration of adverse subjective symptoms during the first postoperative week after corneal collagen cross-linking appear to be milder with epithelial debridement using excimer laser transepithelial technique compared with -assisted debridement and mechanical debridement.
Comparison of The Mechanical Properties of The Anterior Lens Capsule in Senile Cataract, Senile Cataract with Trypan Blue Application, and Pseudoexfoliation Syndrome
(2017) Simsek, Cem; Oto, Sibel; Yilmaz, Gursel; Altinors, Dilek Dursun; Akman, Ahmet; Gungor, Sirel Gur; https://orcid.org/0000-0001-8003-745X; https://orcid.org/0000-0003-0171-4200; https://orcid.org/0000-0002-2589-7294; https://orcid.org/0000-0001-5223-0279; https://orcid.org/0000-0001-6178-8362; 28917406; N-8970-2018; AAJ-4668-2021; AAK-6987-2021; AAK-8077-2021; AAD-5967-2021
Purpose: To evaluate the elastic modulus, hardness, and mechanical properties of the anterior lens capsule in different types of cataract and to assess the correlation with age. Setting: Baskent University Hospital, Department of Ophthalmology, Ankara, Turkey. Design: Prospective comparative study. Methods: Patients were divided into 3 groups. Group 1 comprised patients with senile cataract, Group 2 patients had pseudoexfoliation (PXF) syndrome, and Group 3 patients had dye-enhanced cataract surgery. The capsules were analyzed using a nanoindentation device. Young's modulus of elasticity was measured by the Oliver-Pharr method and capsule hardness by the Martens method. Results: The study comprised 72 patients, 24 per group. The mean Young's modulus was 7.53 GPa +/- 1.07 (SD) in Group 1, 6.01 +/- 1.25 GPa in Group 2, and 8.12 +/- 0.98 GPa in Group 3. The capsules in Group 2 were more elastic than in Group 1 and Group 3 (P < .001). The capsules in Group 3 had lower elasticity than in Group 1, although the difference was not significant (P = .94). The mean capsule stiffness was 326.41 +/- 98.40 MPa in Group 1, 210.5 +/- 52.32 MPa in Group 2, and 315.54 +/- 163.15 MPa in Group 3. The lens capsules in Group 2 were less stiff than those in Group 1 and Group 3 (P < .001). Conclusions: Capsule thickness was positively correlated with increasing age in all groups. The anterior lens capsules of patients with PXF had more elasticity and less stiffness than the other groups. Intracameral trypan blue application had no effect on capsule elasticity and stiffness. (C) 2017 ASCRS and ESCRS
Comparison of Visual Performance and Quality of Life with A New Nondiffractive EDOF Intraocular Lens and A Trifocal Intraocular Lens
(2023) Asena, Leyla; Dogan, Irem Kirci; Oto, Sibel; Altinors, Dilek Dursun; 0000-0003-0171-4200; 0000-0002-6848-203X; 0000-0002-5574-7318; 36700928; AAJ-4668-2021; E-5914-2016
Purpose: To compare visual performance and quality of life (QoL) following bilateral implantation of a new nondiffractive extended depth-of-focus (EDOF) intraocular lens (IOL) and a trifocal IOL. Setting: Department of Ophthalmology, Baskent University Faculty of Medicine, Ankara, Turkey. Design: Prospective comparative interventional case series. Methods: 104 eyes of 52 patients with cataract, bilaterally implanted with a nondiffractive EDOF IOL or a trifocal IOL, were included. Outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), distance corrected intermediate visual acuity and distance corrected near visual acuity, defocus curves, QoL (Visual Function Index 14), quality of vision (Quality of Vision [QoV] index), contrast sensitivity (Pelli-Robson chart), and binocular reading speed. Results: Twenty-six patients were included in each group. The UDVA and CDVA were better in the EDOF group (0.05 +/- 0.04 and 0.01 +/- 0.04) than the trifocal group (0.13 +/- 0.06 and 0.11 +/- 0.07) (P=.02 and .01). Defocus curves showed that visual acuity was better with the EDOF IOL for vergences at 0.00, -0.50, and -1.00 and better with the trifocal IOL for vergences at -2.50, -3.00, -3.50, and -4.00. Contrast sensitivity scores were similar with both IOLs (P=.12). The overall mean QoL scores were lower in the EDOF group, indicating a better QoL (P=.04). The QoV was better in the EDOF group with significantly less glare, halos, and blurry vision (P<.01). Conclusions: The EDOF IOL performed better at distance, and the trifocal IOL performed better at near. Overall QoL and quality of vision were better with the EDOF IOL. Copyright (c) 2023 Published by Wolters Kluwer on behalf of ASCRS and ESCRS
Customizing Illumination by the Operating Microscope Aids the Visualization of DMEK Grafts
(2018) Altinors, Dilek Dursun; Asena, Leyla; Yilmaz, Gursel; Oto, Sibel; 0000-0001-5223-0279; 0000-0002-2589-7294; 0000-0003-0171-4200; AAK-8077-2021; AAK-6987-2021; AAJ-4668-2021
Descemet's Membrane Endothelial Keratoplasty (DMEK): 6-Month Clinical Outcomes
(2018) Altinors, Dilek Dursun; Asena, Leyla; Yilmaz, Gursel; Oto, Sibel; 0000-0001-5223-0279; 0000-0002-2589-7294; 0000-0003-0171-4200; AAK-8077-2021; AAK-6987-2021; AAJ-4668-2021
THE EFFECT OF CORNEAL TRANSPLANTATION ON VISUAL FUNCTION AND VISION-RELATED QUALITY OF LIFE
(2020) Asena, Leyla; Altinors, Dilek Dursun; Oto, Sibel
Effects of topical Coenzyme Q10, Xanthan Gum and Sodium Hyaluronate on corneal epithelial wound healing
(2021) Asena, Leyla; Gokgoz, Gulsah; Helvacioglu, Fatma; Ozgun, Gonca; Deniz, Emine Ebru; Altinors, Dilek Dursun; 0000-0002-6848-203X; 0000-0002-4837-7937; 0000-0002-6026-0045; 34134604; E-5914-2016; AAY-7932-2021; AAH-8887-2021
Background: The aim was to compare the effects of three different eye drops on corneal epithelial wound healing in an experimental model. Methods: Twenty-four eyes of 24 female BALB/c mice were included. A 2 mm central corneal epithelial defect was created. Topical Coenzyme Q10 + Vitamin E D-alpha-TPGS 4 x 1 was applied to Group A (n = 6), topical Sodium hyaluronate + Xanthan Gum + 0.3% Nethylmicine 4 x 1 to Group B (n = 6) and topical Sodium hyaluronate 4 x 1 to Group C (n = 6). Group D (n = 6) was the control group without treatment. Clinical scoring according to corneal fluorescein staining and histopathological evaluations was performed. Results: Clinical scores according to corneal fluorescein staining were similar in all groups on days 1 (p = 0.05), 2 (p = 0.15) and 3 (p = 0.62). Electron microscopy revealed disruption of intercellular junctions between corneal epithelial cells and intracellular vacuole formation in all groups except Group A. Corneal epithelial thickness and superficial epithelial microvillus arrangement were close to normal in Group A. Conclusion: Although there was no difference in clinical scores between groups, electron microscopy revealed a better organised epithelium with normal configuration of microvilli and less vacuolisation in Group A
Human Breast Milk Drops Promote Corneal Epithelial Wound Healing
(2017) Asena, Leyla; Suveren, Esra Hulya; Karabay, Gulten; Altinors, Dilek Dursun; 0000-0001-5223-0279; 0000-0002-6848-203X; 27759431; AAK-8077-2021; E-5914-2016
Purpose: To investigate the effects of human breast milk on corneal epithelial wound healing. Methods: The effects of human breast milk on epithelial healing is compared with autologous serum and artificial tears on 24 female Bal-b/C mice. A central corneal epithelial defect was created using a 2 mm trephine. Four groups were formed. By a random pick-up, topical human breast milk 4 x 1 was given to Group 1, topical mouse autologous serum 4 x 1 was applied to Group 2, and preservative-free artificial tears 4 x 1 was applied to Group 3.Group 4 was evaluated as control. Biomicroscopical examination was performed on days 1, 2, and 3. Mice were sacrificed on the third day. Histopathological and electron microscopic examinations were performed as well. Results: The fastest and best healing group was Group 1, followed by Group 2. Re-epithelization was not complete even at the end of the second day in groups 3 and 4. Conclusions: The rich content of human breast milk may be an alternative to epithelial healers and artificial tears.
LIMBAL STEM CELL TRANSPLANTATION FOR RESTORATION OF THE OCULAR SURFACE HEALTH IN BILATERAL LIMBAL STEM CELL DEFICIENCY
(2020) Altinors, Dilek Dursun; Asena, Leyla; Oto, Sibel
Results of Combined Penetrating Keratoplasty and Implantation of Posterior Chamber Intraocular Lenses
(2018) Asena, Leyla; Altinors, Dilek Dursun; Yilmaz, Gursel; Oto, Sibel; 0000-0001-5223-0279; 0000-0002-2589-7294; 0000-0003-0171-4200; AAK-8077-2021; AAK-6987-2021; AAJ-4668-2021
SIMPLE LIMBAL EPITHELIAL TRANSPLANTATION (SLET) IN A PATIENT WITH LIMBAL STEM CELL DEFICIENCY
(2020) Altinors, Dilek Dursun; Asena, Leyla; Oto, Sibel
Simple limbal epithelial transplantation (SLET) in a patient with limbal stem cell deficiency.
(2019) Asena, Leyla; Altinors, Dilek Dursun; Oto, Sibel
Topical Bevacizumab for the Treatment of Ocular Surface Squamous Neoplasia
(2015) Asena, Leyla; Altinors, Dilek Dursun; 26114378
Purpose: To determine the efficacy and safety of topical bevacizumab treatment in patients with ocular surface squamous neoplasia (OSSN). Methods: Six eyes of 6 patients with primary OSSN confirmed by impression cytology received topical 5mg/mL bevacizumab 4 times daily for a period of 8 weeks. Patients were evaluated in 2-week intervals. Digital photography images were obtained at each visit and changes in the size of the lesions were analyzed by image analysis software. Results: The mean age of the patients was 6613 (+/- SD) years. Four tumors were nasal in origin and 2 tumors were temporal. The mean reduction observed in the lesion area was 43%+/- 24.2% (range, 20%-71%) in the first month and 68%+/- 29.7% (range, 42%-100%) in the second month when compared with the baseline area. Four patients required tumor excision at the end of the treatment period. Surgical treatment was not necessary in 2 patients due to complete disappearance of the tumor, which was confirmed by impression cytology. The visual acuity was stable in all patients and no systemic or visual side effects were observed during the study period. Conclusions: Topical bevacizumab is effective as a neoadjuvant therapy combined with surgical excision for the treatment of OSSN. Topical bevacizumab may be used before surgery to decrease the size of the excision. Excision may be unnecessary in responsive patients.
VISUAL REHABILITATION AFTER PENETRATING KERATOPLASTY
(2020) Asena, Leyla; Altinors, Dilek Dursun; Oto, Sibel
Visual Rehabilitation After Penetrating Keratoplasty
(2018) Asena, Leyla; Altinors, Dilek Dursun; Yilmaz, Gursel; Oto, Sibel; https://orcid.org/0000-0002-6848-203X; https://orcid.org/0000-0001-5223-0279; https://orcid.org/0000-0002-2589-7294; https://orcid.org/0000-0003-0171-4200; E-5914-2016; AAK-8077-2021; AAK-6987-2021; AAJ-4668-2021