Browsing by Author "Alemdaroglu, S."

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Clinical characteristics of relapsed ovarian cancer patients with striking response to the bevacizumab at first relapse
(2019) Kose, Fatih; Alemdaroglu, S.; Mertsoylu, H.; Besen, A.; Guler, O.; Simsek, S.; Erbay, G.; Onal, C.; Celik, H.
Clinicopathologic characteristics of recurrent endometrioid endometrial cancer patients and analysis of methods used duriing surveillance
(2019) Simsek, S.Y.; Serbetcioglu, G.; Alemdaroglu, S.; Yetkinel, S.; Durdag, G.D.; Celik, H.; 31212025
Objective: To determine cilinicopathologic characteristics of recurrent endometrioid type endometrial cancer patients and analyze the methods applied in detection of recurrent disease during follow-up period. Methods: We have retrospectively reviewed the file records of the 226 patients who had endometrioid type carcinoma. Bimanual pelvic examination, speculum examination, carcinogenic antigen-125 (CA125) testing, vaginal cuff cytologic screening, transabdominal ultrasound (TAUS) and transvaginal ultrasound (TVUS) imagings were performed within the context of routine follow-up control examinations in the post-treatment period in every 3 months within the first 2 years and in every 6 months in the following 2 years and with annual control in the consecutive years. Results: Mean follow-up durations was 25.7 +/- 18.9 months while recurrence rate was 3.1%. The study patient group underwent totally 1116 times TVUS and 1084 times whole TA-US evaluations, 973 times vaginal cuff cytological screening, 1125 times pelvic and general physical examinations beside 1060 times CA-125 testings were performed in accordance with our routinely performed follow-up protocol. The asymptomatic recurrent cases; one of those was dignosed with pelvic examination while diagnosis was established using TA-USG evaluation in the other asymptomatic patient. The other 5 cases were symptomatic. Pelvic examination, Computed Tomograhy and Magnetic Resonance Imaging were utilized in diagnosing 1, 3 and 1 of those patients, respectively. Conclusion: The presence of symptoms and pelvic examination seem to be the most effective modalities in detecting recurrence in follow-up of endometrial cancer. It would be reasonable to optimize intervals between follow-up visits and to determine the appropriate evaluations by considering risk levels of the patients. (C) 2019 Elsevier Masson SAS. All rights reserved.
Paraaortic Lymph Node Involvement is A Stronger Prognostic Factor for Overall Survival in Epithelial Ovarian Cancer Rather Than Pelvic Lymph Node Involvement
(2016) Gunakan, E.; Alemdaroglu, S.; Kucukyildiz, I.; Dursun, P.; Ayhan, A.; Kuscu, E.; 0000-0003-4335-6659; 0000-0002-0992-6980; AAJ-5802-2021; AAI-8400-2021; AAI-8792-2021
The Role of Preoperative Routine Computed Tomography Scanning in The Estimation of High-Risk Factors in Endometrial Cancers
(2018) Coban, G.; Erbay, G.; Kose, F.; Alemdaroglu, S.; Onal, C.; Celik, H.; https://orcid.org/0000-0002-3285-5519; https://orcid.org/0000-0002-1706-8680; https://orcid.org/0000-0002-0156-5973; https://orcid.org/0000-0003-4335-6659; https://orcid.org/0000-0002-2742-9021; AAI-9974-2021; AAK-5370-2021; G-4827-2016; AAI-8400-2021; HOC-5611-2023; AAL-1923-2021
Objective: To examine the role of preoperative computed tomography (CT) in estimation of the high-risk factors in endometrial cancer cases. Materials and Methods: The data from 161 cases who were diagnosed with endometrioid adenocarcinoma with endometrial biopsy, and staged surgically were retrospectively analyzed. The diagnostic performance of a whole abdominal CT scan in terms of tumor diameter, myometrial invasion, cervical, adnexal, omental involvement, as well as pelvic para-aortic nodal involvement was examined. In addition, extra-uterine and extra-nodal incidental signs were identified. Results: The accuracy rate of preoperative CT scanning was found to be 42%, 78%, 80%, 95%, 97%, 88%, 89%, and 88% for tumor diameter, myometrial invasion, cervical, adnexal, and omental involvement, as well as pelvic para-aortic nodal involvement, respectively. Extra-uterine and extra-nodal incidental signs were identified in 18% of the cases. Incidental findings entailed a modification of management only in one case (0.62%). Conclusion: Preoperative CT scan findings do not present an alternative to intraoperative frozen section analysis or surgical staging. However, based on the findings from the preoperative CT scan, accuracy of predictions about which patients require more complex procedures (lymphadenectomy) can be improved, and therefore preoperative CT scanning may prove useful in more effective use of operating rooms.