Browsing by Author "Akkas, Hakan"

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    Effect of mometasone furoate nasal spray on the DNA of nasal mucosal cells
    (2018) Aydin, Erdinc; Akkas, Hakan; Turkoglu Babakurban, Seda; Yurtcu, Erkan; Yilmaz Ozbek, Ozlem; 0000-0001-5067-4044; 0000-0001-6864-7378; 0000-0003-4930-8164; 29714449; AAI-8856-2021; AAJ-2379-2021; AAA-2998-2021
    Background/aim: Allergic rhinitis (AR) is a respiratory disease caused by inflammation of the nasal mucosa. Intranasal corticosteroids (ICs) are an effective treatment for AR; however, their use has been associated with atrophy in nasal mucosae. Because DNA damage has been linked to several chronic diseases, we hypothesize that use of ICs could cause DNA damage in nasal mucosa cells, leading to mucosal atrophy and septal perforation. Materials and methods: Sixty patients with moderate or severe AR were divided randomly into two groups. Mometasone furoate (MF) and antihistamine tablets (desloratadine) were given to the study (IC) group. Physiologic saline and desloratadine were given to the control ((serum physiologic (SP)) group. Nasal irrigation fluid was taken from patients before study commencement and after 4 weeks of treatment. The comet assay was applied to detect DNA damage in nasal mucosa cells. Results: Nineteen patients were excluded, leaving a study population of 41 patients (IC group: 17 patients; SP group: 24 patients). Genotoxic damage was evaluated by comet assay. Conclusion: Treatment with MF spray for 4 weeks does not cause DNA breaks within cells in the nasal mucosa. These results could form the basis of clinical trials involving treatment with different ICs over longer treatment periods.
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    The Role of Meteorologic Factors and Air Pollution on The Frequency of Pediatric Epistaxis
    (2018) Akdogan, M. Volkan; Hizal, Evren; Semiz, Mustafa; Topal, Ozgul; Akkas, Hakan; Kabatas, Aydin; Erbek, Selim S.; 0000-0001-9710-9974; 0000-0002-9699-6783; 0000-0001-6305-5023; 0000-0003-4825-3499; 30273433; AAJ-4584-2021; A-5853-2018; ABI-6777-2020; B-7604-2019
    Fluctuations in atmospheric temperature, humidity, and air pollution are associated with the incidence of epistaxis. To date, no study in the literature has evaluated the effect of air pollution and meteorologic conditions on the pediatric population. We aimed to evaluate the effect of meteorologic factors and air pollution on the frequency of epistaxis in children. Children presenting to an outpatient clinical setting at a tertiary care hospital during a 5-year period ( July 1, 2009, to June 30, 2014) and diagnosed with epistaxis formed the study population. Daily temperature and humidity parameters and average daily atmospheric water vapor pressure, average daily concentration of particulate matter < 10 mu m in diameter, and sulfur dioxide readings were obtained. The distribution of daily parameters was analyzed. Of the 1,559 children with the primary diagnosis of epistaxis, data from 1,330 children were analyzed after excluding patients with coexisting pathologies. Positive correlations were found between the frequency of epistaxis and both the average daily temperature and the difference between the maximum and minimum daily temperature. There was a negative correlation between the epistaxis frequency and the average daily humidity, the difference between the maximum and minimum daily humidity, the average daily concentration of particulate matter, and the sulfur dioxide levels. Our findings suggest that epistaxis in children is related to high temperatures and low humidity.