Browsing by Author "Akcil, Mehtap"

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Body Mass Index, Cholecystitis, Cholelithiasis, Pancreatitis and Imaging of Common Bile Duct Stones
(2014) Coban, Gokcen; Yildirim, Erkan; Gokturk, Savas; Caliskan, Zuhal; Turk, Emin; Akcil, Mehtap; https://orcid.org/0000-0002-4010-2883; https://orcid.org/0000-0002-9057-722X; https://orcid.org/0000-0003-4766-3373; 23838577; P-7533-2014; ABI-3856-2020; AAJ-5609-2021
Purpose:Studies to date have not investigated whether body mass index (BMI) affects the sensitivity and specificity of magnetic resonance cholangiopancreatography (MRCP). The purpose of this study was to investigate the effect of BMI and also concomitant pancreatitis, cholecystitis and cholelithiasis on the sensitivity and specificity of MRCP.Materials and Methods:Between January 2004 and December 2011, 185 patients were included in the study and divided into 3 groups according to BMI as normal, overweight or obese. Both MRCP and endoscopic retrograde cholangiopancreatography (ERCP) were performed in all patients. ERCP was accepted as the gold standard. The accuracy, sensitivity and specificity values of the 3 groups were calculated to determine any effects on the results of the MRCP.Results:Before separating into groups according to BMI, the statistical results for MRCP in the detection of stone disease were as follows: specificity 74.3%, sensitivity 81.7% and accuracy 79%. After dividing the patients into 3 groups according to BMI, the specificity of stone detection with MRCP in the normal-weight group was 93.8% but decreased to 65.5% in the overweight group and to 72% in the obese group. The sensitivity of stone detection with MRCP in the normal-weight group was 85.2% but decreased to 75% in the overweight group and increased to 88.9% in the obese group. The accuracy was 88.3% in the normal-weight group but decreased to 71.6% in the overweight group and to 81.9% in the obese group.Conclusion:Our study showed that MRCP performance was decreased in the overweight and obese groups.
A Clinical Comparison of Cordless and Conventional Displacement Systems Regarding Clinical Performance and Impression Quality
(2014) Acar, Ozlem; Erkut, Selim; Ozcelik, Tuncer Burak; Ozdermr, Erdem; Akcil, Mehtap; https://orcid.org/0000-0001-5685-4409; 24360008; JJF-5618-2023
Statement of problem. it is not clear whether newly introduced cordless displacement systems are better able to manage gingiva than conventional systems. Purpose. The purpose of this in vivo study was to evaluate the gingival management ability of 4 different displacement methods with a standardized subgingival preparation finish line. Material and methods. The effects of 4 displacement techniques on gingival management and impression quality were evaluated by means of 6 evaluation criteria. A subgingival preparation finish line of between 1 and 2 mm was ensured, and the buccal aspects of 252 (n=63) teeth were clinically assessed for ease of application, time spent, bleeding, remnants, and dilatation. The complete reproduction of the preparation finish line and the bubble and void formations on polyether impressions were also evaluated. The data were statistically analyzed with the chi(2) test (alpha=.05). The Bonferroni correction was used to control Type I error for the pairwise comparison groups (alpha=.008). Results. Statistically significant differences were found for all criteria among the groups (P<.05). The nonimpregnated displacement cord group was the least effective group in terms of bleeding and impression quality (P<.008). The aluminum chloride impregnated cord group and the displacement paste with cap group were found to be comparable in terms of remnants, dilatation, and impression quality (P>.008). The retraction cap with paste group showed better results for ease of application, time spent, and bleeding than the aluminum chloride impregnated cord group (P<.008). Although the group with aluminum chloride impregnated cord, displacement paste, and cap showed better results for dilatation, it was time consuming and difficult (P<.008). Conclusions. Except for the nonimpregnated cord group, all of the groups were comparable and clinically useful, with perfect or acceptable impression qualities.
The Clinicopathological and Prognostic Significance of CD24, CD44, CD133, ALDH1 Expressions in Invasive Ductal Carcinoma of The Breast CD44/CD24 Expression in Breast Cancer
(2015) Kapucuoglu, Nilgun; Bozkurt, Kemal Kursat; Baspinar, Sirin; Kocer, Murat; Eroglu, Hasan Erol; Akdeniz, Rasit; Akcil, Mehtap; 26298632
Background: Recently, there are several studies about cancer stem cells (CSC), indicating that they are the cells that initiate the tumor, provide progression, metastasis and responsible for the aggressive tumor behavior. Materials and methods: The purpose of this study is to investigate the expressions of CD24, CD44, their different combinations, ALDH1 and CD133 in invasive ductal carcinoma. Their relationships with clinicopathologic parameters, such as tumor grade, lymphovascular invasion, tumor size, axillary lymph node involvement, stage, hormone receptors, HER2 expression, basal like tumors, triple negative status and prognosis were also investigated. Tissue microarray method was used to investigate immunohistochemical CD24, CD44, ALDH1 and CD133 expressions in 105 invasive ductal carcinoma cases. Results: CD 133 expression was significantly associated with tumor size (p = 0.023) and stage (p = 0.009). CD133 expression was decreased in tumors with larger tumor size, higher stage and lymphovascular invasion. CD133 expression was positively correlated with CD44 (r = 0.212, p = 0.032) and CD44(+)/CD24(+) (r = 0.202, p = 0.040) expressions. CD44, CD24 and ALDH1 expressions showed no significant relationship and correlation with clinicopathologic features. There was a significant relationship (p = 0.048) between CD44(+)/CD24(-/low) phenotype and basal like tumors. EGFR expression was positively correlated with CD44(+)/CD24(-/low) phenotype (r = 0.211, p = 0.036). Conclusions: Basal like tumors are enriched for CSCs with CD44(+)/CD24(-/low) phenotype. CD133 can detect a different population of CSC in breast carcinoma. (C) 2015 Elsevier GmbH. All rights reserved.