Browsing by Author "Akalin, Nalan"

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    Does measles immunization lead to immunization for COVID-19? Case series
    (2021) Akkucuk, Mehmet Husamettin; Akalin, Nalan; Gulalp, Betul; https://orcid.org/0000-0003-4569-1143; https://orcid.org/0000-0002-2045-2771; AAJ-2828-2021; P-6931-2016
    There are many studies on protective, preventive and treatment methods for about Covid-19 pandemic, which affects the whole world.The results of epidemiological studies also guide these researches. The studies of the scientists who are struggling with this pandemic worldwide reveal that the incidence of covid-19 is low in the child age group and the disease survived more mildly in childhood. There is an opinion about the reason why covid-19 disease is seen less frequently and milder in pediatric patients, that active immunization created with childhood vaccines. For this reason, we compared the Rubeola immunoglobulin levels formed aganist the measles vector, one of the childhood vaccines which has antigenic similarity with the SARS-CoV family, in patients diagnosed with covid-19 in our hospital and Rubeola immunoglobulin levels of screening performed in healthy individuals before pandemi. As a result , we found the measles IgG levels were statistically significantly higher in patients diagnosed with measles IgG covid-19 compared to the control group. According to this result, this significant increase in level after being infected with SARS-CoV2 in patients with measles immunization may have positive effects on the course of the disease. In addition. we saw that all our Covid-19 patients with high measles antibody recovered without serious mortality and morbidity , despite their age, gender and chronic diseases. Therefore , considering the completion process of vaccination studies, we think that measles vaccination can be applied to risky groups without contraindications to reduce the existing destructive effects of the disease.
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    Shrinkage of Nasal Mucosa and Cartilage During Formalin Fixation
    (2017) Kansu, Leyla; Aydin, Erdinc; Akkaya, Hampar; Avci, Suat; Akalin, Nalan; 0000-0003-1707-7760; 0000-0001-6864-7378; 0000-0003-2155-8014; 0000-0002-7070-6901; 28552840; H-8232-2013; AAJ-2379-2021; ABG-2028-2020; O-3636-2018
    Background: After resection, specimens are subjected to formalin fixation during histological processing. This procedure can result in tissue shrinkage, with the amount of shrinkage related to tissue composition and tissue type. Aims: To evaluate the shrinkage of nasal mucosa and cartilage tissue and compare differences in shrinkage after resection, after formalin fixation, and during microscopic examination to understand differences in the rate of shrinkage of different tissue types. Study Design: Animal experimentation. Methods: Fresh nasal septa were excised from sheep (10 mm diameter in 40 sheep and 20 mm diameter in 40 sheep). The mucosa was separated from one side of the cartilage, with the contralateral mucosa remaining attached to the cartilage. Specimen diameters were measured in situ, after resection, after fixation for 6 or 24 hours (10% formalin), and during microscopic examination. Results: There were no differences between the in situ and after resection diameters of any tissue components (free mucosa, mucosa attached to cartilage, and cartilage) of all nasal specimens (10-or 20-mm diameter and 6or 24-hour fixation). However, significant shrinkage occurred between resection and after-fixation. Regarding tissue specimens that were fixed for different durations (6 or 24 hours), we observed a significantly smaller mean tissue diameter in specimens fixed for 24 hours versus those fixed for 6 hours for mucosa attached to cartilage (in the 10-mm diameter after-fixation samples), free mucosa (in the 20-mm diameter after-fixation samples), mucosa attached to cartilage (in the 20-mm diameter after-fixation and microscopic measurement samples), and cartilage (in the 20-mm diameter after-fixation samples). Tissue shrinkage was greatest in free mucosal tissue and least in cartilage. Conclusion: These results should be considered when evaluating patients undergoing surgical procedures for nasal cavity and paranasal sinus malignancies. Surgical margins should be measured before fixation or evaluated if possible before fixation and shrinkage.