Browsing by Author "Abdulaziz Fayazov"

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Infusion Therapy During the Period of Toxemia of Burn Disease
(Başkent Üniversitesi, 2021-06) Abdulaziz Fayazov; Khuriya Mukhitdinova; Akmal Mirzakulov; Khikmat Anvarov
OBJECTIVES:In this study, our objective was to study the features of infusion therapy during the period of toxemia of burn disease in adults. MATERIALS AND METHODS: Results of monitoring of the daily volume of injected fluid, infusion therapy, and renal excretory activity of 25 patients were studied. All patients had been admitted to the Department of Combustiology in the Republican Research Center of Emergency Medicine (Tashkent, Uzbekistan) because of burn injury. After recovery from shock, all patients received the following treatments: anti-inflammatory agents, antibacterial therapy, correction of protein and water-electrolyte balance disorders, early surgery, delayed necrectomy, addi-tional parenteral nutrition, and syndrome- and symptom-specific therapy. All parameters were compared and studied among 3 age groups: group 1 consisted of 12 patients from 20 to 40 years old (average 27.3 ± 5.6 years), group 2 consisted of 7 patients from 41 to 60 years old (average 50.7 ± 7.1 years), and group 3 consisted of 6 patients from 61 to 78 years old (average 71.3 ± 7.0 years). RESULTS: The average daily volume of infusion therapy in group 1 (Frank index 119.4 ± 38.4 U) was 76 ± 7 mL/kg/day; in group 2 (Frank index 92.5 ± 20.8 U), daily administration was 64 ± 9 mL/kg/day; and in group 3 (Frank index 86.7 ± 12.8 U), daily administration was 48 ± 11 mL/kg/day. CONCLUSIONS: In the fluctuating nature of changes in intravenous infusion, which may occur over 4 to 5 days, there are a number of factors that determine the need to increase or decrease infusion therapy. During the period of toxemia, the hourly renal excretory activity was most evident in patients in group 1, corresponding to a greater volume of water load and severity of burn injury. In group 2, which had average infusion therapy of 64 ± 9 mL/kg/day, preclinical signs of overload in pulmonary circulation were shown.
Prediction of Development of Acute Gastroduodenal Complications in Patients With Severe Burns
(Başkent Üniversitesi, 2021-09) Abdulaziz Fayazov; Adkham Akhmedov; Akmal Mirzakulov; Abdukakhor Nabiev
OBJECTIVES: Our aim was to find whether we could predict the likelihood of acute gastroduodenal complications developing in patients with severe burns. MATERIALS AND METHODS: From 2018 to 2020, there were 85 patients with extensive thermal injury and severe burns who were hospitalized at our burn department (Samarkand City Medical Association). Of these, 45 patients (53%) developed acute gastroduodenal complications in the first 7 days postinjury and 40 (47%) did not develop these complications in the first 2 weeks after admission. We analyzed the following 7 parameters: admission time and initiation of intensive care after 12 hours, total burn area of ≥40%, deep burn area ≥10%, lesion severity index (Frank index) of ≥130 units, development of thermal inhalational lesion in the respiratory tract, duration of mechanical ventilation of >48 hours, and history of peptic ulcer disease of >5 years. RESULTS: We found that 57.8% of patients who had postponed hospitalization in a specialized medical institution and started intensive therapy >12 hours later developed acute gastroduodenal complications versus 42.2% of patients without these factors. In those with total burn area <40% and ≥40%, 28.9% versus 71.1% developed acute gastroduodenal complications. At week 2 of burn disease, in patients with deep burn areas ≥10%, acute gastroduodenal complications developed 1.5 times more often. Among patients whose Frank index was ≥130 units, acute gastroduodenal complications developed 9 times more often than among those with Frank index ≤70 units. CONCLUSIONS: The 7 parameters that we used as prognostic criteria could assess patients with extensive thermal injury complicated by the development of burn disease. With these criteria, a scale was created to predict the development of acute gastroduodenal complications. This scale could allow better preparation to treat these complications and to take timely preventive measures.
Treatment of Acute Gastroduodenal Bleeding in Patients With Severe Burn Injuries
(Başkent Üniversitesi, 2021-12) Abdulaziz Fayazov; Adkham Akhmedov
OBJECTIVES: Among causes of gastrointestinal bleeding, stress ulcers occupy the second place, second only to chronic ulcers of the stomach and duodenum; gastrointestinal bleeding accounts for 10% to 20% of all causes of hemorrhage. Bleeding relapses from acute stress ulcers (mortality rate range, 60%-90%) are particularly dangerous. Our aim was to compare treatment methods for patients with bleeding from acute gastroduodenal ulcers after severe burns. MATERIALS AND METHODS: Over the past 10 years at our burn department (Samarkand City Medical Association), 80 patients (average age of 51 ± 16 years; 46.4% older than 60 years) with severe burns and bleeding from acute gastroduodenal ulcers were treated. The total area of thermal damage to the skin indicated the significant severity of thermal injury (average of 36.7 ± 7.7% of body surface). Patients were divided into 2 groups: main group (n = 42; 7-day antiulcer therapy) and control group (n = 38; H2-receptor blockers and traditional treatment). RESULTS: In the main group, VEGF concentrations remained virtually unchanged for 3 days compared with that shown in the control group, with a predisposition for gastroduodenal complications but decreased to 18.5% on day 7 and to 24.2% on day 14. In patients without a tendency for gastroduodenal complications, there was a decrease of 10.9% on day 7 and 15.4% on day 14 compared with patients in the control group. Thus, the use of L-arginine-containing drug in the main group of patients on all sampling days resulted in a decrease of VEGF concentration compared with that shown in the control group. CONCLUSIONS: Stable hemostasis during bleeding from acute gastroduodenal ulcers in patients with severe burn injuries was achieved in 77.8% of the control group (who received antisecretory therapy with H2-receptor blockers) and in 88.1% of the main group (antisecretory treatment with addition of dopamine D2-receptor blockers).