Browsing by Author "Abdulaziz D. Fayazov"

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Comparative Evaluation of Polymers Versus Traditional Approaches for Local Treatment of Burn Wounds in an Experimental Rat Model
(Başkent Üniversitesi, 2021-12) Vladlena U. Ubaydullaeva; Utkur R. Kamilov; Abdulaziz D. Fayazov; Khaydar E. Yunusov
ABSTRACT OBJECTIVES: We aimed to morphologically analyze and compare the wound healing process of burns in an animal model using Levomekol ointment or a polymer coating. The polymer coating was made from carboxymethyl cellulose, which contained stabilized silver nanoparticles at various concentrations. MATERIALS AND METHODS: For our analyses, we used 75 White rats, which were divided into 5 groups, to compare local treatment with Levomekol ointment versus polymer coating containing various concentrations of silver nanoparticles. Biopsy specimens from the central and peripheral sections of treated burn wounds were studied on days 7, 15, and 30 after injury/start of treatment. RESULTS: In rat groups that had local treatment of burn wounds with Levomekol ointment, the period of wound epithelialization was 37.2 ± 0.7 days. In rat groups that had treatment with polymer coating with silver nanoparticles, the epithelialization period was 30.2 ± 0.6 days. The use of a polymer coating with silver nanoparticles in local treatment stimulated the onset of regenerative processes at an earlier date, which was expressed in the active formation of granulation tissue by day 15. CONCLUSIONS: The traditional method of burn wound treatment, which in our study was the use of Levomekol ointment, demonstrated a more protracted course of the wound healing process versus treatment with polymer coating with silver nanoparticles in our study animals. As shown morphologically, the use of the polymer coating treatment made it possible to shorten the recovery process.
Modern Views on the Surgical Treatment Tactics for Deep Electrothermal Injuries
(Başkent Üniversitesi, 2021-12) Abdulaziz D. Fayazov; Davron B. Tulyaganov; Utkir R. Kamilov; Akmal G. Mirzakulov
OBJECTIVES: To improve the treatment outcomes of patients with electrothermal lesions, we compared different surgical methods (modern vs traditional). MATERIALS AND METHODS: In this retrospective analysis, we studied patients with electrothermal lesions who were treated in our burn department at the Republican Research Center of Emergency Medicine (Tashkent, Uzbekistan) from 2008 to 2020. During this period, 445 patients with electric shock were treated; of these, 253 (56.8%) were children. RESULTS/CONCLUSIONS: Among the circumstances for electric trauma, most were household injuries (n = 411; 92.4%). Thirty-four patients (7.6%) had electric trauma injuries while at work. Most patients were men (n = 341; 76.6%). Of 445 patients, 326 (73.3%) had low-voltage electrical trauma, with skin lesions limited to an “electric mark.” In these patients with general electrical trauma and who did not require surgical interventions for thermal tissue lesions, the main emphasis was placed on monitoring cardiovascular activity and monitoring the reaction of parenchymal organs to the effects of low-voltage electricity. For patients who needed surgery, we found that modern methods of surgical treatment for deep electrothermal lesions can shorten the time required for closure of wounds and significantly reduce the development of inflammatory complications. Better treatment can reduce length of stays in the hospital.
Rational Surgical Methods of Deep Burns Treatment in Older Patients
(Başkent Üniversitesi, 2024-09) Abdulaziz D. Fayazov; Shukhrat A. Magdiev; Adham I. Akhmedov
ABSTRACT OBJECTIVES: We describe our experience with surgical treatment of elderly (aged >60 years) patients with deep burns. Available data have indicated that the best results can be achieved with a single-stage autologous skin grafting to close all wounds in one step for limited deep burns. For extensive burns, the best results are achieved with delayed autologous skin grafting performed in 1 to 2 stages. Use of early surgical intervention methods for deep burns in elderly patients substantially reduces the recovery time of skin integrity, the frequency of burn disease complications, and mortality. MATERIALS AND METHODS: We examined the results of comprehensive treatment of 69 patients seen in the combustiology department of the Samarkand City Medical Association from 2019 to 2023. Inclusion criteria included presence of deep burns of III-B to IV degree and age 60 years or older. All 69 patients had a Baux index exceeding 60 units. RESULTS: Elderly patients who received surgical debridement followed by autodermoplasty for treatment of deep burns had average skin recovery period after injury of 30.6 ± 2.0 days. Rate of autodermotransplant graft lysis among patients was 20.3%. Better outcomes were achieved with simultaneous autodermoplasty than with delayed autodermoplasty (11.8% vs 23.1%). The average postoperative mortality rate among patients with thermal injuries was 8.7%; mortality was 6.9% in patients with a Baux index of 60 to 80 but reached 11.1% in patients with more severe trauma. CONCLUSIONS: The application of surgical debridement methods in elderly patients significantly reduced the recovery time of skin surface, frequency of burn disease complications, and mortality rates. Simultaneous autodermoplasty with closure of all wounds in one stage is effective for limited deep burns. Delayed autodermoplasty performed in 1 to 2 stages can yield better outcomes for elderly patients with extensive burns.