Browsing by Author "Abali, Ayse Ebru"

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A Brief Summary of Long-Term Treatment Modalities for Major Burn Survivors in Low and Middle-Income Countries
(2015) Abali, Ayse Ebru; 0000-0002-1298-7944; 25468470; AAE-8704-2021
Cost-Effective Outpatient Burn-Care for Minor Burns
(2015) Abali, Ayse Ebru; 0000-0002-1298-7944; 25499406; AAE-8704-2021
Efficacy of Acupuncture on Pain Mechanisms, Inflammatory Responses, and Wound Healing in the Acute Phase of Major Burns: An Experimental Study on Rats
(2021) Abali, Ayse Ebru; Cabioglu, Tugrul; Bayraktar, Nilufer; Ozdemir, Binnaz Handan; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0002-1298-7944; 34309681; AAJ-8097-2021; AAE-8704-2021
We investigated acupuncture, a potential contributor for burn care, on physiological and pathological pain mechanisms and systemic and local inflammatory responses in a rat experimental burn model. Forty male Sprague-Dawley rats were divided into two groups. One-hour groups (five rats/group) were observed for 1 hour and included Sh1 (sham/observation), ShA1 (sham + acupuncture/observation), Brn1 (burn/observation), and BrnA1 (burn + acupuncture/ observation). Seven-day groups (five rats/group) were observed for 7 days and included Sh7 (sham/observation), ShA7 (sham + acupuncture/observation), Brn7 (burn/observation), and BrnA7 (burn + acupuncture/observation). "Pain-distress scores" were noted daily, and acupuncture was repeated within every wound-dressing change on alternate days. After observation periods, blood samples for interleukin 6 and beta-endorphin and skin biopsies for inflammatory changes and immunohistochemical staining of interleukin 6 were collected for analysis(P <.05). In 1-hour groups, interleukin 6 accumulation in burn wounds of BrnA1 was less than Brn1, with Brn1 having the highest mean blood level (P <.05). Mean beta-endorphin levels were higher in ShA1, Brn1, and BrnA1 than in Sh1 (P <.05). In all 7-day groups, the agonizing period was 48 to 72 hours after burn, with Brn7 most affected (P <.05). Microvessels were multiplied in the Brn7 group, with significantly higher numbers in burn wounds of BrnA7 (P<.05). Burn wounds of BrnA7 had less accumulation of interleukin 6 than Brn7 with the Brn7 group having the highest mean blood level and Sh7, ShA7, and BrnA7 having similarly low levels (P>.05). Beta-endorphin levels in ShA7, Brn7, and BrnA7 were lower than in Sh7 (P <.05). Acupuncture contributed to the management of physiological and pathological pain, modulation of inflammatory responses, and associated enhancement of angiogenesis in the acute phase of burn injury in rats.
Interactive Effects of Acupuncture on Pain and Distress in Major Burns: An Experiment with Rats
(2015) Abali, Ayse Ebru; Cabioglu, Tugrul; Ozdemir, Handan; Haberal, Mehmet; 0000-0002-1298-7944; 0000-0002-3462-7632; 0000-0002-7528-3557; 25433758; AAE-8704-2021; AAJ-8097-2021; X-8540-2019
This study sought to investigate the interactive effects of acupuncture on pain and distress and the local progress in the burn wound in an experimental major burn model. Forty-eight male Sprague-Dawley rats were divided into six groups: S group (sham/observation during 7 days after injury); SA group (sham/acupuncture/observation during 7 days after injury); Si group (burns/observation during 1 h after injury); BA1 group (burns/acupuncture/observation during 1 h after injury); 57 group (burns/observation during 7 days after injury); and BA7 group (burns/acupuncture/observation during 7 days after injury). Pain and distress scores were evaluated throughout the study. The amounts of neutrophils and mononuclear cells were evaluated semiquantitatively, and the number of microvessels was evaluated quantitatively. Our data indicated that the average pain score of BA7 group was significantly lower than the other study groups. Histopathologic investigations indicate that the amounts of neutrophil and mononuclear cell and numbers of microvessels in the unburned skin were higher in acupuncture-applied groups. The number of microvessels in burn wounds of BA7 group was significantly higher than that of the other groups. Our data suggest that acupuncture provides low pain and distress scores in experimental rat model, and it contributes to wound healing with an enhanced angiogenesis during the acute phase of burns. Future clinical and experimental studies should be conducted to discern the benefits from acupuncture in pain management of burn patients. (C) 2014 Elsevier Ltd and ISBI. All rights reserved.