Browsing by Author "İyidir, Ozlem Turhan"

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    A Bibliometric Analysis of Turkey's Contribution to Bone Health Literature from an Endocrinologist Perspective
    (2019) Degertekin, Ceyla Konca; İyidir, Ozlem Turhan; Yavuz, Dilek Gogas; 0000-0001-5305-6807; K-7904-2019
    Objective: To analyze the trend of Turkish publications related to bone health with respect to global publications and to determine the relative contribution of endocrinologists to metabolic bone disease literature. Material and Methods: Publications related to bone health up to and including the year 2017 were retrieved from the "Web of Science" (WoS) and "TUrkiye Atif Dizini" (TAD) database using metabolic bone disease related MeSH terms. Excel (v15.30) and Endnote X8 were used to summarize the bibliometric features, including the number of publications, authors, their affiliations, and contributing countries. Keywords were divided, for a detailed analysis, into three clusters: osteoporosis, parathyroid, and vitamin D-related. Results: A total of 1.880.666 papers were retrieved from WoS globally and, of those, 21.165 (1.13%) were published from Turkey. Of the papers published from Turkey, 3.0% were primarily contributed by endocrinologists. The relative contribution of endocrinology to osteoporosis-related (4.6% vs. 1.5%), parathyroid-related (23.7% vs. 5.3%), and vitamin D-related (23.7% vs. 5.3%) publications was higher for articles originating from Turkey compared to the global data. Endocrinology was among the top five specialties contributing to Turkish metabolic bone disease literature indexed in WoS and TAD. Conclusion: Turkey has a less than expected rate of research output in terms of metabolic bone disease. The relatively higher contribution of endocrinology to that effort is promising. Supporting bone research might accelerate the efforts of Turkish researchers in the field of metabolic bone health.
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    Insulin, Glucagon and Growth Hormone and CIMT in Glucose Intolerance
    (2017) İyidir, Ozlem Turhan; Demir, Ozgur; Emral, Rifat; 0000-0001-5305-6807; K-7904-2019
    Objective: There is an increasing evidence that glucagon and growth hormone (GH)-insulin-like growth factor (IGF) axis may play an important role in glucose metabolism since early stages of glucose intolerance. Carotid intima media thickness is a marker for subclinical atherosclerosis. We aimed to evaluate glucagon, GH and IGF-1 in prediabetic states and their relationship with carotid intima media thickness. Methods: One hundred subjects underwent a 75 gr oral glucose tolerance test and were divided into 4 groups according to their state of glucose tolerance: (i) normal glucose tolerance (NGT)/Controls (n=21), (ii) impaired glucose tolerance (IGT) (n=35), (iii) impaired fasting glucose (IFG) (n=22), (iv) type 2 diabetes mellitus (n=22). Insulin, glucagon and GH were measured at 0, 60 and 120. minutes of OGTT and their area under the curve (AUC) were calculated. Fasting IGF-1 levels and carotid intima media thickness were determined in all participants. Results: AUC for Glucagon was significantly higher in subjects with IGT, IFG and type 2 diabetes mellitus compared to NGT subjects. AUC for GH was significantly higher in subjects with IFG compared to subjects with IGT, type 2 diabetes mellitus and NGT. Plasma IGF-1 levels were significantly lower in subjects with abnormal glucose tolerance. CIMT was significantly higher in IFG group and CIMT was found to be negatively correlated with IGF-1 levels in subjects with IFG. Conclusion: There are pathological alterations of glucagon, GH-IGF-1 and insulin in prediabetic stages. Among these alterations insulin resistance and IGF-1 are associated with CIMT. Further studies needed to investigate the role of treatments targeting insulin sensitivity will have an impact on the association between insulin and early atherogenesis