Browsing by Author "Totan, Yuksel"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Acute effects of exercise on choroidal thickness and ocular pulse amplitude
    (2019) Dervisogulları, Mehmet Serdar; Totan, Yuksel; Kulak, Ali Ender; Guler, Emre; 0000-0003-2006-2906; G-7851-2015
    Aim: To explore ocular changes in healthy people after exercise. Material and Method: Twenty participants underwent exercise for 15 minutes on a treadmill. Measurements of choroidal thickness, intraocular pressure (IOP), ocular pulse amplitude (OPA), and blood pressure were taken before and after exercise. Enhanced Depth, Imaging optical coherence tomography (EDI-OCT) was used to measure choroidal thickness at the fovea and at the areas 1500 mu m nasal and 1500 mu m temporal to the fovea; IOP and OPA were measured by the dynamic contour tonometer (DCT; Swiss Micro technology AG, Port, Switzerland). Blood pressure was measured concurrently with the acquisition of the scans. Results: Twenty participants (20 eyes) with a mean age of 22.65 +/- 0.98 years were measured. There was a significant increase in systolic and diastolic pressure after exercise (p<0.05). There was a significant decrease in IOP and OPA after exercise (p<0.05). There was no significant difference in the subfoveal, nasal or temporal choroidal thickness measurements after exercise (p>0.05). Discussion: In our study, there was no significant change in the thickness of the choroid after exercise. IOP and OPA significantly decreased, and systolic and diastolic blood pressure significantly increased, after exercise. This indicates an adaptation of vascular resistance due to vasoconstriction. The IOP and OPA decreases do not seem to be related with the changes in choroid thickness.
  • Thumbnail Image
    Item
    The adverse effects of valproic acid on visual functions in the treatment of retinitis pigmentosa
    (2017) Yuce, Aslihan; Totan, Yuksel; Guler, Emre; Dervisogullari, Mehmet Serdar; 29044065
    Purpose: To evaluate the efficacy and safety of valproic acid (VPA) treatment in patients with retinitis pigmentosa (RP). Methods: A total of 48 eyes of 24 patients (13 males, 11 females) with RP prescribed VPA were included. The length of VPA treatment was 6-12 months (mean 9.4 months). Parameters evaluated were best-corrected visual acuity (BCVA) (logarithm of the minimum angle of resolution [logMAR]), visual field analyses (VFAs) with Humprey automated perimetry, multifocal electroretinography (ERG) with Roland-RETI scan, and VPA side effects. Results: Mean age was 34.3 +/- 10.3 years (range 18-56 years). Fifteen of the patients (30 eyes) had two ERG and VFA tracings, allowing comparison between baseline and follow-up (range 6-12 months). Mean BCVA before and after VPA therapy was 0.36 +/- 0.38 and 0.36 +/- 0.37 logMAR, respectively (P = 0.32). Quantitative perimetric indices including mean deviation and pattern standard deviation were not significantly changed after VPA therapy (P > 0.05). P1 amplitudes (in terms of nV/deg(2) and mV) of ERG waves were significantly decreased in the rings 1, 3, and 4 after VPA therapy (P < 0.05). Regarding the N1 amplitudes, the only significant decrease was observed in area 1 (P = 0.03). In addition, N1 latency was significantly increased in area 3 after VPA therapy (P = 0.04). Conclusions: VPA therapy did not have any significant benefit on BCVA and VFA. In addition, it may be associated with decline in some ERG parameters. Therefore, physicians should avoid prescribing VPA for RP until its safety and efficacy are appropriately evaluated.