Browsing by Author "Polat, Aysegul Yucel"
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Item COMPARISON OF RAPAMYCIN WITH CYCLOSPORIN, AND TACROLIMUS IN REGARDS TO THE DEVELOPMENT OF EPITHELIAL-TO-MESENCHYMAL TRANSITION (EMT) OF TUBULAR CELLS AND ENDOTHELIAL-TO-MESENCHYMAL TRANSITION (ENDOMT) OF PERITUBULAR CAPILLARIES (PTCS)(2020) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Atilgan, Alev Ok; Akcay, Eda; Polat, Aysegul Yucel; Akdur, Aydincan; Haberal, Mehmet A.Item Divergent Role of Programmed Death -Ligand 1 (PD-L1) in Renal Allografts with Antibody-Mediated Rejection (AMR)(2018) Ozdemir, B. Handan; Akcay, Eda; Atilgan, Alev Ok; Borcek, Pelin; Tepeoglu, Merih; Polat, Aysegul Yucel; Deniz, Melis; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0001-8595-8880; https://orcid.org/0000-0002-9894-8005; https://orcid.org/0000-0002-3590-9375; AAJ-8097-2021; X-8540-2019; AAK-1960-2021; AAK-3333-2021; AAK-5222-2021; AAP-3975-2021; https://orcid.org/0000-0002-3462-7632Item Divergent Role of Programmed Death-Ligand 1 in Renal Allografts with Antibody-Mediated Rejection(2018) Ozdemir, B. Handan; Akcay, Eda Yilmaz; Atilgan, Alev Ok; Borcek, Pelin; Tepeoglu, Merih; Polat, Aysegul Yucel; Deniz, Isinsu Melis; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0001-6831-9585; 0000-0001-8595-8880; 0000-0002-9894-8005; 0000-0002-3462-7632; X-8540-2019; AAK-1960-2021; AAK-3333-2021; AAK-5222-2021; AAJ-8097-2021Item HEPATOCYTE GROWTH FACTOR (HGF) PREVENTS THE APOPTOTIC AND ANTI-ANGIOGENIC EFFECT OF HYPERCHOLESTEROLEMIA ON HEPATOCYTES IN LIVER ALLOGRAFTS(2020) Ozdemir, B. Handan; Ozgun, Gonca; Polat, Aysegul Yucel; Haberal, Nihan; Moray, Gokhan; Haberal, Mehmet A.Item Impact of Vitamin D3 on Cytoskeletal Reorganization and Regulation of Adherens Junctions of Tubule Cells: Epithelial to Mesenchymal Transition and Development of Interstitial Fibrosis in Renal Allografts(2018) Ozdemir, B. Handan; Ozdemir, Fatma Nurhan; Ayva, Ebru Sebnem; Akcay, Eda Yilmaz; Soy, Ebru H. Ayvazoglu; Ozdemir, Gokce; Polat, Aysegul Yucel; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0002-2280-8778; 0000-0002-0993-9917; 0000-0003-2545-0078; 0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; AAK-1967-2021; AAC-5566-2019; AAL-4282-2020; AAJ-8097-2021Item MiR-25 and KLF4 relationship has early prognostic significance in the development of cervical cancer(2021) Polat, Aysegul Yucel; Ayva, Ebru Sebnem; Gurdal, Hakan; Ozdemir, Binnaz Handan; Dedeoglu, Bala Gur; 0000-0002-7528-3557; 33862560; X-8540-2019Cervical squamous cell carcinoma (SCC) is one of the common cancer types among women. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in the formation and development of many cancer types by regulating expression of their targets. While many studies have investigated the relationship between miRNAs and cervical cancer, no robust miRNA biomarkers have been defined yet for diagnosis of cervical lesions. In this study, we performed a statistical meta-analysis to identify miRNAs and a class compassion analysis to evaluate mRNAs with the power to discriminate between normal, intraepithelial lesions and invasive cancer samples. Differentially expressed (DE) mRNAs were compared with the targets of meta-miRNAs. After bioinfomatics analysis and qRT-PCR validations with cytology samples and FFPE tissues, we defined miR-25 and its target KLF4 (Kruppel-like factor 4) as candidate biomarkers for in vitro studies. Our results showed that miR-25 expression was significantly higher in precancerous lesions and invasive carcinoma while presenting consistent expression patterns in both cytological and FFPE tissue samples. In line with this, its direct target KLF4 expression decreased in precancerous lesions in cytological samples and also in the invasive cancer group in FFPE tissues. Furthermore, in vitro studies showed that mir-25 inhibition decreased proliferation and motility of HeLa cells and promoted an increase in the protein level of KLF4. We conclude that inhibition of miR-25 may upregulate KLF4 expression and regulate cell proliferation and motility in cervical cancer.Item MULTIFACTORIAL EFFECT OF HEPATOCYTE GROWTH FACTOR (HGF) ON THE MICROSCOPIC REGENERATION OF LIVER ALLOGRAFT IN RECIPIENTS WHO UNDERWENT TRANSPLANTATION FROM LIVING DONORS(2020) Ozdemir, B. Handan; Ozgun, Gonca; Polat, Aysegul Yucel; Haberal, Mehmet A.Item RAPAMYCIN PREVENTS INTERSTITIAL FIBROSIS THROUGH DECREASING PERITUBULAR CAPILLARY (PTC) VEGF EXPRESSION AND ANGIOGENESIS WHILE INDUCING GLOMERULAR SCLEROSIS AND PROTEINURIA THROUGH DECREASING GLOMERULAR VEGF EXPRESSION(2020) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Akcay, Eda; Atilgan, Alev Ok; Polat, Aysegul Yucel; Akdur, Aydincan; Haberal, Mehmet A.