Browsing by Author "Kyrgidis, Athanassios"

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Dermatoscopy Of Nodular/Plaque-Type Primary Cutaneous T- And B-Cell Lymphomas: A Retrospective Comparative Study With Pseudolymphomas And Tumoral/Inflammatory Mimickers By The International Dermoscopy Society
(2022) Errichetti, Enzo; Geller, Shamir; Zalaudek, Iris; Longo, Caterina; Kyrgidis, Athanassios; Akay, Bengu Nisa; Piccolo, Vincenzo; Myskowski, Patricia; Vitiello, Paola; Russo, Teresa; Argenziano, Giuseppe; Slawinska, Martyna; Sokolowska-Wojdylo, Malgorzata; Sobjanek, Michal; Toncic, Ruzica Jurakic; Rados, Jaka; Drvar, Daniela Ledic; Ceovic, Romana; Kaminska-Winciorek, Grazyna; Lanssens, Sven; Gulec, Ayse Tulin; Lobato-Berezo, Alejandro; Damiani, Giovanni; Maione, Vincenzo; Calzavara-Pinton, Piergiacomo; Sotiriou, Elena; Stinco, Giuseppe; Apalla, Zoe; Lallas, Aimilios; 34695527
Background: Limited data on dermatoscopy of nodular/plaque-type T-/B-cell primary cutaneous lymphomas (PCLs) is available. Objective: To describe dermatoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histologic subtypes. Methods: Participants were invited to join this retrospective, multicenter case-control study by submitting histologically/immunohistochemically confirmed instances of nodular/plaque-type PCLs and controls. Standardized assessments of the dermatoscopic images and comparative analyses were performed. Results: A total of 261 lesions were included (121 PCLs and 140 controls). Orange structureless areas were the strongest PCL dermatoscopic predictor on multivariate analysis compared with tumors and non infiltrative inflammatory dermatoses. On the other hand, a positive association was found between PCLs and either unfocused linear vessels with branches or focal white structureless areas compared with infiltrative inflammatory dermatoses, whereas white lines were predictive of PCLs over pseudolymphomas. Differences in the vascular pattern were also seen between B-and T-cell PCLs and among B-cell PCL subtypes. Limitations: Retrospective design and the lack of a dermatoscopic-pathologic correlation analysis. Conclusion: Nodular/plaque-type PCLs display dermatoscopic clues, which may partially vary according to histologic subtype and whose diagnostic relevance depends on the considered clinical differential diagnoses. ( J Am Acad Dermatol 2022;86:774-81.)
Dermoscopy Features of Atypical Fibroxanthoma: A Multicenter Study of The International Dermoscopy Society
(2018) Moscarella, Elvira; Piana, Simonetta; Specchio, Francesca; Kyrgidis, Athanassios; Nazzaro, Gianluca; Eliceche, Maite L.; Savoia, Francesco; Bugatti, Leonardo; Filosa, Giorgio; Zalaudek, Iris; Scarfi, Federica; Inskip, Mike; Rosendahl, Cliff; Pyne, John H.; Siggs, Graeme; Cabo, Horatio; Drlik, Lubomir; Lallas, Aimilios; Longo, Caterina; Argenziano, Giuseppe; 29569417
Background/Objectives Little is known about the dermoscopic features of atypical fibroxanthoma. Methods Results This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%). Dermoscopically, most atypical fibroxanthoma displayed red (83%) and white (70%) structureless areas and irregular linear vessels (43%). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the criteria achieved statistical significance. When basal cell carcinoma was excluded, three variables achieved statistical significance in predicting atypical fibroxanthoma: red, structureless areas, the absence of opaque yellowish-white scales and absence of white circles. Conclusions Atypical fibroxanthomas seem to be barely distinguishable from basal cell carcinoma dermoscopically, but they are more easily distinguishable from a well to moderately differentiated squamous cell carcinoma. A histopathological examination is needed for the final diagnosis.