Fakülteler / Faculties
Permanent URI for this communityhttps://hdl.handle.net/11727/1395
Browse
45 results
Search Results
Item Machine Learning Based Orthodontic Treatment Planning for Mixed Dentition Borderline Cases Suffering from Moderate to Severe Crowding: An Experimental Research Study(2023) Senirkentli, G. Burcu; Bingol, Sinem Ince; Unal, Metehan; Bostanci, Erkan; Guzel, Mehmet Serdar; Acici, Koray; 36970921BACKGROUND: Pedodontists and general practitioners may need support in planning the early orthodontic treatment of patients with mixed dentition, especially in borderline cases. The use of machine learning algorithms is required to be able to consistently make treatment decisions for such cases. OBJECTIVE: This study aimed to use machine learning algorithms to facilitate the process of deciding whether to choose serial extraction or expansion of maxillary and mandibular dental arches for early treatment of borderline patients suffering from moderate to severe crowding. METHODS: The dataset of 116 patients who were previously treated by senior orthodontists and divided into two groups according to their treatment modalities were examined. Machine Learning algorithms including Multilayer Perceptron, Linear Logistic Regression, k-nearest Neighbors, Naive Bayes, and Random Forest were trained on this dataset. Several metrics were used for the evaluation of accuracy, precision, recall, and kappa statistic. RESULTS: The most important 12 features were determined with the feature selection algorithm. While all algorithms achieved over 90% accuracy, Random Forest yielded 95% accuracy, with high reliability values (kappa = 0.90). CONCLUSION: The employment of machine learning methods for the treatment decision with or without extraction in the early treatment of patients in the mixed dentition can be particularly useful for pedodontists and general practitioners.Item First Terbinafine-Resistant Trichophyton indotineae Isolates with Phe397Leu and/or Thr414His Mutations in Turkey(2023) Durdu, Murat; Kandemir, Hazal; Karakoyun, Ayse Sultan; Ilkit, Macit; Tang, Chao; de Hoog, Sybren; https://orcid.org/0000-0003-1247-3932; 36656402; H-9068-2019Fungal infections of the skin, nails, and hair caused by dermatophyte species continue to be a worldwide concern. The increase in terbinafine-resistant superficial dermatophytosis has become a major concern over the last decade. In this report, we presented two cases of infection with terbinafine-resistant Trichophyton indotineae, the first diagnosis of this species in Turkey. One patient exhibited erythematous pruritic patches and plaques in the inguinal and gluteal regions, while the other patient showed annular erythematous scaly plaques in the bilateral posterior thigh and gluteal regions. One patient harbored a CD36 mutation. Both strains harbored the same amino acid substitution in the squalene epoxidase gene, whereas one isolate had another unknown mutation. Clinical improvement was observed with resveratrol treatment in the patient with the CD36 mutation but not in the other patient.Item Multivariate Analysis of the Factors Affecting Tinnitus Severity in Old Age: A Multi-Center Cross- Sectional Study(2023) Ozer, Fulya; Cabuk, Gozde Bayramoglu; Mutlu, Meryem; Simsek, Agit; Erbek, Selim Sermed; https://orcid.org/0000-0003-4825-3499; B-7604-2019Aim: The purpose of this study was to analyze the factors affecting tinnitus severity in the population aged 60 and over with a multi-central data and with multivariate analysis. Materials: This prospective study was composed of 130 subjects aged 60 years or older with clinical complaint of tinnitus and administered to five different otorhinolaryngology clinics in four different cities in our country. All participants have been tested with pure tone audiometry. Tinnitus loudness and pitch mapping were determined for all participants. All participants also interviewed individually to complete Tinnitus Handicap Inventory (THI) and asked to characterize their tinnitus symptoms using a visual analog scale (VAS) measuring severity, annoyance of tinnitus. Results: Tinnitus loudness increases significantly in the group over the age of 79, but there is no significant difference between the groups formed according to age in terms of VAS or THI values. Systemic disease does not make a significant difference that increases the severity of tinnitus. risk factors that increase tinnitus severity are included in the logistic regression analysis; High level of education and advanced age over 79 years were determined as independent risk factors. Increasing education level is an independent risk factor for increasing tinnitus severity with an odds ratio of 2.46 (95% CI, 1.080-5.624). At the same time, advanced age over 79 years is an independent risk factor with an odds ratio of 5.4 (95% CI, 1,385-21.197), which causes tinnitus severity to be felt more. Conclusion: In old age population, the incidence of tinnitus does not increase with increasing age, but tinnitus severity increases. As hearing loss increases, tinnitus severity and VAS score increase. According to the results of this study, the most important risk factors that increase the perception of tinnitus in the elderly population were determined as very advanced age and high education level. It is reasonable to think that one of the reasons for this is that the elderly in the vulnerable group for the Covid 19 pandemic should stay away from hospitals unless their tinnitus complaints are very serious. Re-performing our study in elderly individuals after the pandemic is important to see the effect of the pandemic period more clearly in these individuals.Item Cytogenetic Profile and Phenotypical and Reproductive Complaints in 39 Patients with Turner Syndrome: A Single Center Experience(2023) Kazanci, Ferah; Celik, Zerrin; https://orcid.org/0000-0001-9158-220X; A-1229-2015Background/Aim: Turner syndrome (TS) is a genetic failure that influence phenotypic girls who have full or incomplete monosomy of X chromosome with a variety of clinical signs. The purpose of this study was to estimate TS cases based on their cytogenetic findings and clinical implications. Material and methods:Thirty-nine cases diagnosed with TS were retrospectively analyzed between November 2006 and December 2019. These patients were identified among 505 people who had their karyotypes analyzed for different reasons, including primary amenorrhea (PA), premature ovarian insufficiency (POI), TS phenotype, and uterine agenesis (UA). Karyotype analysis was carried out using Giemsa staining in accordance with the standard method on peripheral blood and fluorescence in situ hybridization (FISH) was used when necessary. Results: The median age of TS cases were 15 years (ranging from 4 to 32). The distribution of reasons for admission was as follows: 61.5% TS phenotype, 25.6% PA, 10.3% POI, and 2.6% UA with horseshoe kidney. The frequency of cytogenetic finding was 38.5% pure monosomy X and 61.5 % mosaic [30.7% monosomy X with structural rearrangements, 18% with X chromosomal structural abnormalities, 7.7% with X aneuploidy and 5.1% with Y chromosomal structural abnormalities]. The most accepted reason for both pure and mosaic TS group was TS phenotype. Conclusion: TS develops when one sex chromosome is wholly or incompletely removed as well as structurally altered. Phenotype, fertility, and life quality may differ according to the variability of cytogenetic findings. Comprehensive cytogenetic analysis is required for the patients for medical follow-up and genetic counselling.Item Endoplasmic Reticulum Stress Response in Non-Alcholic Fatty Liver Disease: Sophisticated Pathways(2023) Etik, Digdem Ozer; Verdi, Hasibe; Atac, Fatma Belgin; https://orcid.org/0000-0001-6868-2165; V-5499-2017; ABG-9966-2020Non-alcoholic fatty liver disease comprises a broad spectrum of fat-associated liver conditions that can result in end-stage liver disease and the need for liver transplantation. The multiparallel hypothesis suggests that steatohepatitis is the result of numerous conditions acting in parallel, including form genetic susceptibility, lipotoxicity, disturbed gut microbiata to mitochondrial dysfunction, and endoplasmic reticulum(ER) stress. The unfolded protein response as the ER stress response is coordinated primarily by ER transmembrane stress transducers which is a defensive response initially activates the cell to recover from stress or adapt to stress. It reduces the secretory protein load, enhances protein folding and increases clearance capacity by promoting autophagy and ER-associated degradation. However, if these attempts fail or the ER stress gets prolonged, it will induce cell death programs to eliminate the stressed cells. In recent years, ER stress response has been identified as a crucial mechanism in steatohepatitis by leading improper lipid biosynthesis, inflammation, and autophagy or apoptosis.Item Use of Cardiac Imaging in Chronic Coronary Syndromes: The EURECA Imaging Registry(2023) Sade, Leyla Elif; 36452988Background The prospective, multicentre EURECA registry assessed the use of imaging and adoption of the European Society of Cardiology (ESC) Guidelines (GL) in patients with chronic coronary syndromes (CCS). Methods Between May 2019 and March 2020, 5156 patients were recruited in 73 centres from 24 ESC member countries. The adoption of GL recommendations was evaluated according to clinical presentation and pre-test probability (PTP) of obstructive coronary artery disease (CAD). Results The mean age of the population was 64 11 years, 60% of patients were males, 42% had PTP >15%, 27% had previous CAD, and ejection fraction was <50% in 5%. Exercise ECG was performed in 32% of patients, stress imaging as the first choice in 40%, and computed tomography coronary angiography (CTCA) in 22%. Invasive coronary angiography (ICA) was the first or downstream test in 17% and 11%, respectively. Obstructive CAD was documented in 24% of patients, inducible ischaemia in 19%, and 13% of patients underwent revascularization. In 44% of patients, the overall diagnostic process did not adopt the GL. In these patients, referral to stress imaging (21% vs. 58%; P < 0.001) or CTCA (17% vs. 30%; P < 0.001) was less frequent, while exercise ECG (43% vs. 22%; P < 0.001) and ICA (48% vs. 15%; P < 0.001) were more frequently performed. The adoption of GL was associated with fewer ICA, higher proportion of diagnosis of obstructive CAD (60% vs. 39%, P < 0.001) and revascularization (54% vs. 37%, P < 0.001), higher quality of life, fewer additional testing, and longer times to late revascularization. Conclusions In patients with CCS, current clinical practice does not adopt GL recommendations on the use of diagnostic tests in a significant proportion of patients. When the diagnostic approach adopts GL recommendations, invasive procedures are less frequently used and the diagnostic yield and therapeutic utility are superior. [GRAPHICS]Item Comparison of Surgical Techniques Used in Ventricular Septal Defect Closure(2023) Celik, Mehmet; Aygun, Fatih; Gunaydin, Asim Cagri; Gokdemir, Mahmut; Cindik, Nimet; 0000-0002-5018-0068; 36592069; AAT-2031-2021Introduction: We compared transatrial closure, tricuspid valve septal detachment, and tricuspid valve chordal detachment techniques for ventricular septal defect (VSD) closure. Methods: Patients who had VSD closure with three different techniques in our clinic between September 2016 and December 2020 were retrospectively reviewed. A total of 117 patients were included in the study. The patients were divided into three groups: group 1, classical transatrial closure; group 2, closure with tricuspid valve septal detachment; and group 3, closure with tricuspid valve chordal detachment. The groups were evaluated by serial transthoracic echocardiography (preoperative, postoperative 1st day, postoperative 1st month). Cardiac rhythm checks and recordings were performed. Results: No residual VSD was observed in early or late periods in any of the groups whose VSD closure was performed with the three different techniques. No severe tricuspid regurgitation (TR) was detected during the early and late postoperative periods of all operating procedures. When the groups were compared in terms of early/late TR after the operation (without TR+trace amount of TR and mild TR+moderate TR were compared), no statistically significant difference was found (P>0,05; P=0,969 and P>0,05; P=0,502). Conclusion: In this study, we found no statistically significant difference between three VSD closure techniques in terms of early TR, late TR, residual VSD, and permanent atrioventricular complete block during postoperative period. We hope that our results will be supported by the results of researches that are being made about this subject in large series.Item Biochemical, Radiologic, Ultrastructural, and Genetic Evaluation of Iron Overload in Acute Leukemia and Iron-chelation Therapy(2014) Olcay, Lale; Hazirolan, Tuncay; Yildirmak, Yildiz; Erdemli, Esra; Terzi, Yunus Kasim; Arda, Kemal; Ozturkmen, Seda; Akyay, Arzu; Kaymak-Cihan, Meric; Bicakci, Zafer; Bal, Ceylan; https://orcid.org/0000-0001-5612-9696; https://orcid.org/0000-0002-4480-7784; 23887025; B-4372-2018; ABI-7551-2020Iron overload in hereditary hemochromatosis and hematologic malignancy has unfavorable effects on morbidity. Herein, 53 children (age 108.4 +/- 58.3 mo, 25 girls and 28 boys) with acute myeloblastic and lymphoblastic leukemia, who received 4 different chemotherapy protocols, were evaluated for iron overload throughout chemotherapy. Iron overload arose: (1) before chemotherapy, which was dependent on neither chemotherapy nor packed red blood cell transfusions and (2) after chemotherapy, which was dependent on the duration and nature of chemotherapy and partially on transfusion of packed red blood cells. Iron overload was documented in 75% of patients with a ferritin level >1000 ng/mL, by liver and heart magnetic resonance imaging, and they were administered iron-chelation therapy with success. Three of 10 radiologically iron-overloaded patients were heterozygous for H63D mutation. Aminolevulinic acid and porphobilinogen levels were normal. Light microscopic examination of the bone marrow revealed increased iron granules in erythroblasts, platelets, and megakaryocytes, iron-laden macrophages, free iron in the matrix, dyshematopoiesis, and apoptotic cells. Electron microscopic examination revealed iron-laden secondary lysosomes and autolysosomes in normoblasts and iron-laden primary granules in promyelocytes, irrelevant to the ferritin level, implying autophagia due to chemotherapy as a source of the excess iron. We think that iron overload, which is an important complication of acute leukemia, should be evaluated separately from transfusion overload, and the management principles specific to leukemia should be implemented.Item Primary Ovarian Malignant Melanoma Arising in Teratomatous Component of Mixed- Germ Cell Tumor in a Child: Case report(2014) Ozyoruk, Derya; Demir, Haci Ahmet; Emir, Suna; Haberal, Asuman Nihan; Bugdayci, Meral; Otgun, Ibrahim; https://orcid.org/0000-0001-9852-9911; 24499012; AAK-4587-2021Primary ovarian malignant melanoma arising in teratomatous component of germ cell tumors is seen extremely rare with most reports being only of single cases and small series in reproductive aged woman and mostly from cystic teratoma, whereas information on pediatric presentation is sparse. This case is reported for being extremely rare tumor.Item Management of Early Hepatic Arterial Thrombosis After Liver Transplantation(2014) Moray, G.; Kirnap, M.; Soy, E. Ayvazoglu; Yildirim, S.; Sezgin, A.; Boyvat, F.; Haberal, M.; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0002-5735-4315; https://orcid.org/0000-0002-3462-7632; AAE-1041-2021; AAH-9198-2019; AAC-5566-2019; AAF-4610-2019; F-4230-2011; AAJ-8097-2021