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Item Pre-Chemoradiotherapy High Platelet Counts Predict Jaw Osteoradionecrosis In Locally Advanced Nasopharyngeal Carcinoma Patients(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-09-15) Somay, Efsun; Topkan, Erkan; Kucuk, Ahmet; Ozturk, Duriye; Ozkan, Emine Elif; Ozdemir, Beyza Sirin; Besen, Ali Ayberk; Mertsoylu, Huseyin; Pehlivan, Berrin; Selek, UgurIntroduction: This retrospective study aimed to investigate if pretreatment platelet (PLT) levels can predict the risk of osteoradionecrosis of the jaw (ORNJ) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) who received concurrent chemoradiotherapy (CCRT). Material &Methods: ORNJ instances were identified from LA-NPC patients' pre- and post-CCRT oral exam records. All pretreatment PLT values were acquired on the first day of CCRT. Receiver operating characteristic curve analysis was used to determine the optimal PLT cutoff that divides patients into two subgroups with distinctive ORNJ rates. The primary outcome measure was the association between pretreatment PLT values and ORNJ incidence rates. Results: The incidence of ORNJ was 8.8 % among the 240 LA-NPC patients analyzed. The ideal pre-CCRT PLT cutoff which divided the patients into two significantly different ORNJ rate groups was 285,000 cells/mu L (PLT <= 285,000 cells/mu L (N = 175) vs. PLT > 285,000 cells/mu L (N = 65)). A comparison of the two PLT groups revealed that the incidence of ORNJ was substantially higher in patients with PLT > 285,000 cells/L, than in those with PLT <= 285,000 cells/L, (26.2% vs. 2.3 %; P < 0.001). The presence of pre-CCRT >= 3 tooth extractions, any post-CCRT tooth extractions, mean mandibular dose >= 34.1 Gy, mandibular V57.5 Gy >= 34.7 %, and postCCRT tooth extractions > 9 months after CCRT completion were also associated with significantly increased ORNJ rates. A multivariate Cox regression analysis demonstrated that each characteristic had an independent significance on ORNJ rates after CCRT. Conclusion: An affordable and easily accessible novel biomarker, PLT> 285,000 cells/L, may predict substantially higher ORNJ rates after definitive CCRT in individuals with LA-NPC. (c) 2024 Elsevier Masson SAS. All rights reserved.Item Comment on "Management of 80 Sinonasal Undifferentiated Carcinomas. Retrospective Multicentre Study of the French Network of Rare Head and Neck Cancers (REFCOR).(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-06-21) Topkan, Erkan; Somay, Efsun; Selek, UgurItem Letter to the Editor: Local Treatment of Children Suffering From Parameningeal Rhabdomyosarcoma - A Retrospective Single-Center Study From China(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-05-19) Topkan, Erkan; Somay, Efsun; Selek, Ugur; Pehlivan, BerrinItem Comment on 'Accelerated Hypofractionated Chemoradiation For Locally Advanced Head And Neck Cancer During Covid-19 Pandemic: A Tertiary Care Experience'(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-10-30) Somay, Efsun; Topkan, Erkan; Selek, Ugur; Pehlivan, BerrinItem Comment on Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Somay, Efsun; Topkan, ErkanItem Comment on Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Somay, Efsun; Topkan, ErkanItem Comment on Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-21) Somay, Efsun; Topkan, ErkanItem Reduced-dose radiotherapy for Epstein-Barr virus DNA selected staged III nasopharyngeal carcinoma: A single-arm, phase 2 trial(Başkent Üniversitesi Diş Hekimliği Fakültesi, 2024-03-29) Topkan, Erkan; Somay, Efsun; Selek, Ugur; Pehlivan, BerrinItem The Extent Of Unnecessary Tooth Loss Due To Extractions Prior To Radiotherapy Based On Radiation Field And Dose İn Patients With Head And Neck Cancer(Başkent Üniversitesi Mühendislik Fakültesi, 2024-03-27) Somay, Efsun; Topkan, Erkan; Selek, UgurItem Predictive Potential Of Pan-Immune-Inflammation Value / Hemoglobin Index As Biomarker For Osteoradionecrosis Risk In Locally Advanced Nasopharyngeal Carcinomas(JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY, 2024-03-27) Yilmaz, Busra; Somay, Efsun; Topkan, Erkan; Pehlivan, Berrin; Besen, Ali Ayberk; Mertsoylu, Huseyin; Selek, UgurObjective: We aimed to investigate whether the Pan-Immune-Inflammation-Value/Hemoglobin (PIV/Hb) index could predict the risk of osteoradionecrosis (ORN) in patients receiving concurrent chemoradiotherapy (CCRT) for locally advanced nasopharyngeal cancer (LA-NPC). Materials and methods: This retrospective analysis included LA-NPC patients who underwent CCRT and preCCRT oral exams at our institution's Departments of Radiation Oncology and Dentistry between January 2010 and December 2022. The relationship between ORN rates and PIV-Hb levels was explored using receiver operating characteristic curve analysis. The primary objective was to establish a correlation between pre-CCRT PIV-Hb levels and ORN rates, while the secondary objective was to identify other risk factors for ORN. Results: Of 249 eligible patients, 21 (8.4 %) were diagnosed with ORN. The optimal pre-CCRT PIV/Hb cutoff was 73.8, which divided patients into two subgroups with distinctive ORN risk estimates: Group 1: PIV/ Hb < 73.8 (N = 206), and Group 2: PIV/Hb >= 73.8 (N = 43). The results of the comparative analysis indicated that the cohort with PIV/Hb >= 73.8 exhibited substantially higher rates of ORN than the PIV/Hb < 73.8 cohort (44.2 % vs. 1.0 %; P < 0.001). The multivariate logistic regression analysis indicated that the pretreatment PIV/ Hb >= 73.8 was independently associated with higher ORN rates (P < 0.001). Conclusion: The results of our current investigation indicate that higher levels of pretreatment PIV/Hb were associated with a significant independent increase in ORN rates in LA-NPC patients who received CCRT. (c) 2024 Elsevier Masson SAS. All rights reserved.