SATEN III-Splitting Adjuvant Treatment of stage III ENdometrial cancers: an international, multicenter study
dc.contributor.author | Kahramanoglu, Ilker | |
dc.contributor.author | Meydanli, Mehmet Mutlu | |
dc.contributor.author | Taranenka, Siarhei | |
dc.contributor.author | Ayhan, Ali | |
dc.contributor.author | Salman, Coskun | |
dc.contributor.author | Sanci, Muzaffer | |
dc.contributor.author | Demirkan, Fuat | |
dc.contributor.author | Ortac, Fırat | |
dc.contributor.author | Haidopoulos, Dimitrios | |
dc.contributor.author | Sukhin, Vladyslav | |
dc.contributor.author | Kaidarova, Dilyara | |
dc.contributor.author | Stepanyan, Artem | |
dc.contributor.author | Farazaneh, Farah | |
dc.contributor.author | Aliyev, Shamistan | |
dc.contributor.author | Ulrikh, Elena | |
dc.contributor.author | Kurdiani, Dina | |
dc.contributor.author | Yalcin, Ibrahim | |
dc.contributor.author | Mavrichev, Siarhei | |
dc.contributor.author | Akilli, Huseyin | |
dc.contributor.author | Sari, Mustafa Erkan | |
dc.contributor.author | Pletnev, Andrei | |
dc.contributor.author | Aslan, Koray | |
dc.contributor.author | Bese, Tugan | |
dc.contributor.author | Kairbayev, Murat | |
dc.contributor.author | Vlachos, Dimitrios | |
dc.contributor.author | Gultekin, Murat | |
dc.date.accessioned | 2020-10-23T12:23:30Z | |
dc.date.available | 2020-10-23T12:23:30Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1048-891X | en_US |
dc.identifier.uri | http://hdl.handle.net/11727/4962 | |
dc.description.abstract | Introduction The purposes of this study were to compare adjuvant treatment modalities and to determine prognostic factors in stage III endometrioid endometrial cancer (EC). Methods SATEN III was a retrospective study involving 13 centers from 10 countries. Patients who had been operated on between 1998 and 2018 and diagnosed with stage III endometrioid EC were analyzed. Results A total of 990 women were identified; 317 with stage IIIA, 18 with stage IIIB, and 655 with stage IIIC diseases. The median follow-up was 42 months. The 5-year disease-free survival (DFS) of patients with stage III EC by adjuvant treatment modality was 68.5% for radiotherapy (RT), 54.6% for chemotherapy (CT), and 69.4% for chemoradiation (CRT) (p=0.11). The 5-year overall survival (OS) for those patients was 75.6% for RT, 75% for CT, and 80.7% for CRT (p=0.48). For patients with stage IIIA disease treated by RT versus CT versus CRT, the 5-year OS rates were 75.6%, 75.0%, and 80.7%, respectively (p=0.48). Negative peritoneal cytology (HR: 0.45, 95% CI: 0.23 to 0.86; p=0.02) and performance of lymphadenectomy (HR: 0.33, 95% CI: 0.16 to 0.77, p=0.001) were independent predictors for improved OS for stage IIIA EC. For women with stage IIIC EC treated by RT, CT, and CRT, the 5-year OS rates were 78.9%, 67.0%, and 69.8%, respectively (p=0.08). Independent prognostic factors for better OS for stage IIIC disease were age <60 (HR: 0.50, 95%CI: 0.36 to 0.69, p<0.001), grade 1 or 2 disease (HR: 0.59, 95% CI: 0.37 to 0.94, p=0.014; and HR: 0.65, 95%CI: 0.46 to 0.91, p=0.014, respectively), absence of cervical stromal involvement (HR: 063, 95% CI: 0.46 to 0.86, p=0.004) and performance of para-aortic lymphadenectomy (HR: 0.52, 95% CI: 0.35 to 0.72, p<0.001). Discussion Although not statistically significant, CRT seemed to be a better adjuvant treatment option for stage IIIA endometrioid EC. Systematic lymphadenectomy seemed to improve survival outcomes in stage III endometrioid EC. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1136/ijgc-2019-000643 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | endometrial neoplasms | en_US |
dc.subject | radiotherapy | en_US |
dc.subject | lymphatic metastasis | en_US |
dc.title | SATEN III-Splitting Adjuvant Treatment of stage III ENdometrial cancers: an international, multicenter study | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 1271 | en_US |
dc.identifier.endpage | 1279 | en_US |
dc.identifier.wos | 000491395600008 | en_US |
dc.identifier.scopus | 2-s2.0-85072017275 | en_US |
dc.contributor.pubmedID | 31481453 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
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