Bayar, Sezin AkcaPinarci, Eylem YamanKarabay, GultenAkman, AhmetOto, SibelYilmaz, Gursel2024-02-142024-02-1420141120-6721http://hdl.handle.net/11727/11519Purpose: To report the ocular findings of patients with Alport syndrome and the results of clear lens extraction in this patient group. Methods: Twenty-three eyes of 15 patients with a diagnosis of Alport syndrome were included in this study. Clear corneal phacoemulsification and intraocular foldable lens implantation was performed in eyes with indeterminate refractive errors and/or poor visual acuity and anterior capsule samples were analyzed with electron microscopy. Results: All patients had a history of hereditary nephritis and/or deafness as systemic involvement. Ophthalmologic examination revealed anterior lenticonus with high myopia and/or irregular astigmatism in all patients. The mean best-corrected visual acuity (BCVA) was 0.67 +/- 0.17 logMAR (range 1.0-0.4) preoperatively and 0.17 +/- 0.08 logMAR (range 0.3-0.0) postoperatively. Postoperative refractive lenticular astigmatism dramatically decreased and no ocular complications arose during the follow-up period. Transmission electron microscopic analysis of the lens capsules supported the diagnosis of Alport syndrome. Conclusions: Clear lens phacoemulsification and foldable intraocular lens implantation is a safe and effective therapeutic choice for the management of uncorrectable refractive errors and low visual acuity due to anterior lenticonus in patients with Alport syndrome.enginfo:eu-repo/semantics/closedAccessAlport syndromeAnterior lenticonusClear corneal phacoemulsificationElectron microscopic analysisarticle243345351000337652600009