Mowla, AshkanShakibajahromi, BanafshehShahjouei, ShimaBaharvahdat, HumainHarandi, Ali AminiRahmani, FarzadMondello, StefaniaRahimian, NasrinCernigliaro, AchilleHokmabadij, Elyar SadeghiEbrahimzadeh, Seyed AmirRamezani, MahtabMehrvar, KavehFarhoudi, MehdiNaderi, SoheilFenderi, Shahab MahmoudnejadPishjoo, MasoudAlizada, OrkhanPurroy, FranciscoRequena, ManuelTsivgoulis, GeorgiosZand, Ramin2023-09-192023-09-1920230022-510Xhttps://pdf.sciencedirectassets.com/271029/1-s2.0-S0022510X22X00117/1-s2.0-S0022510X22003598/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjENT%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCIDetXsa621jIcuS14VhKyaSd4EDTHfrkP%2F7LCfJUrrFxAiAd2E8IFZ%2BEOm5DyRhk8fgWn5biO2U%2FwVIVLO%2FTG09YNyq8BQi8%2F%2F%2F%2F%2F%2F%2F%2F%2F%2F8BEAUaDDA1OTAwMzU0Njg2NSIMUBsWiCBEmOrHXZ6rKpAFb34SKADAeXUGlrdSZUwcqziWKTihcMEMIqt0vFd5rUxrDNScgKZnOXNBvS9bbf%2BpvGWltOVScBrlXdPWZVmQh%2FrzvaY7HTx8jxupwHmkWXFYJCFYX%2F0jFTbN0uNEuk0fN5E6zIcpaiEcRMTt%2BAKwP7LBPummqBt4iVn4EMeXHVzsCJVeWedBo%2BsFwjdmdoyW8xdKCqGcmSbMLq1%2B9LMhEfbN5OwaByfztiCtxNgG2HbBH6T8FAogg8nIPAdkGy5DwSHpgC7zL9VMAV%2BG5XxK%2FbdfuQ2Cl82NKP1b%2BatNVgnh8QSsSsunnw%2Fk3aLJbBt6JM%2B2HeMuLITOv0rXZ%2Fhon9LpBoOC388xMrmVe6d%2FiA75LuLy5cIbBERR%2BR8%2BSTDA4PmI0J58v2Eur44%2BgWv3kyFDxTSlJmU47Mh2RY%2BTEiMsjDSuSD%2FznviDNLYKOJycoHgUxskqHZMOtyq%2FhwjGl2PpcTMFWiQM6y1u0gH4ZzDm%2FF5kpdNkRpRT7Jo4zbu18Kklvz%2F67Wm3UqaVxztwRZiIc2jqQVPd13lfoR5AE773HXzZEzfYIJ23pHLyrZEZepp2HXt0lErEdgfdl1lcJi5X5HVxO%2BGGOJgFX96cFb1F%2BELsMZFUn48TuzQUTzSGnKeM7MaPVzBFH2sfA7rce%2BEfeiX4PDysNXpTur8c6a4tnUie2hR5khLq06LUf7HCi7lwYTVfnSLQqIIVU9BocDqiwZix83TKwJsT80u4vfnIT1pxdER9W4zOkDQ4b2d9J5sqyxTeHrAGDuN3AU89A%2Bwehc%2BsTMfdhKPJpJGoQjYM1l7tmbTeNqa5LJT86FqGMrN8%2FY8T5iJRJho9vvwS5ISntAm%2BV6At36VR9E3a19gw64WmqAY6sgFEZ%2B6tFH1xM25ZH8O0ICqeQobobnGAisRGL%2FX2UYBUxxlRuiJUGRlld0jqtEkK8IZzjEfgLIUrrk1dV1Q0UlozTbcgAlvzaHya2bZFR1pHS%2FG3l2Rqfb2wG15E2qY9BGpxWWrDEzvmDaqf2%2Flb4W32HdPsC%2Fv%2FSgOPnucG0%2FaLsCLUupu%2BK%2B8jwTMaMJBPQutHQzcuDhnJrvwUK2POsH9JMohkflP%2FPWLY2DXL6CsP72cX&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20230919T120840Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYRSDJQ7WF%2F20230919%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=2e1db196d583d513fb300293302e040505c3dacf34da9df8f6b443c431fcedc5&hash=dd6396c5bf28a5bbb9740d50ada53eb506b570135b03fe3d9746f2a9f2d0189c&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0022510X22003598&tid=spdf-aadc5699-231e-4e9d-ba39-1eb82e2e056b&sid=5e2e07e32cd726414c9bf2d977174bd9fee1gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0e1458535d5f0559575600&rr=8091b721be8a515a&cc=trhttp://hdl.handle.net/11727/10696Background: SARS-CoV-2 infection may be associated with uncommon complications such as intracerebral hemorrhage (ICH), with a high mortality rate. We compared a series of hospitalized ICH cases infected with SARS-CoV-2 with a non-SARS-CoV-2 infected control group and evaluated if the SARS-CoV-2 infection is a predictor of mortality in ICH patients.Methods: In a multinational retrospective study, 63 cases of ICH in SARS-CoV-2 infected patients admitted to 13 tertiary centers from the beginning of the pandemic were collected. We compared the clinical and radiological characteristics and in-hospital mortality of these patients with a control group of non-SARS-CoV-2 infected ICH patients of a previous cohort from the country where the majority of cases were recruited.Results: Among 63 ICH patients with SARS-CoV-2 infection, 23 (36.5%) were women. Compared to the non-SARS-CoV-2 infected control group, in SARS-CoV-2 infected patients, ICH occurred at a younger age (61.4 +/- 18.1 years versus 66.8 +/- 16.2 years, P = 0.044). These patients had higher median ICH scores ([3 (IQR 2-4)] versus [2 (IQR 1-3)], P = 0.025), a more frequent history of diabetes (34% versus 16%, P = 0.007), and lower platelet counts (177.8 +/- 77.8 x 109/L versus 240.5 +/- 79.3 x 109/L, P < 0.001). The in-hospital mortality was not significantly different between cases and controls (65% versus 62%, P = 0.658) in univariate analysis; however, SARS-CoV-2 infection was significantly associated with in-hospital mortality (aOR = 4.3, 95% CI: 1.28-14.52) in multivariable analysis adjusting for potential confounders.Conclusion: Infection with SARS-CoV-2 may be associated with increased odds of in-hospital mortality in ICH patients.enginfo:eu-repo/semantics/openAccessCOVID-19Intracerebral hemorrhageMortalityOutcomeSARS-CoV-2Strokearticle4440008929559000052-s2.0-85142904666