Yildirim, Ali ErdemDalgic, AliDivanlioglu, DenizhanAkdag, RifatCetinalp, Nuri EralpAlagoz, FatihHelvacioglu, fatmaTake, GulnurGuvenc, YahyaKoksal, IsmetBelen, Ahmed Deniz2019-11-272019-11-2720151019-5149http://turkishneurosurgery.org.tr/pdf/pdf_JTN_1530.pdfhttp://hdl.handle.net/11727/4265AIM: Catechin is a type of polyphenol, along with epicatechin, epigallocatechin, and epigallocatechin-gallate (EGCG). This study aims to investigate the effect of EGCG, a major metabolite of catechin, which is the principle bioactive compound in green tea, on rats with peripheral nerve injury. MATERIAL and METHODS: A total of 74 rats were divided into six groups, namely the control, the trauma, the normal saline, a 25mg/kg EGCG, a 50mg/kg EGCG and a daily consumption group (10mg/kg EGCG was given intraperitoneally for 14 days before the trauma). Except the first group, the other groups underwent a 1-minute sciatic nerve compression by clip with 50gr/cm(2) pressure. Nerve samples were obtained at 28 day after trauma for the biochemical and histopathological analysis. RESULTS: Our study showed that the Daily consumption, 25mg/kg EGCG and 50mg/kg EGCG groups demonstrated statistically significant decreased lipid peroxidation levels and particularly daily consumption, and the 25mg/kg EGCG group showed a favourable reduction of degeneration and edema histologically. CONCLUSION:This study shows that Catechin and its derivatives have a protective effect on peripheral nerve injury.enginfo:eu-repo/semantics/openAccessAxonal degenerationEpigallocatechin-gallateElectron microscopeLight microscopeLipid peroxidationPeripheral nerve injuryarticle2534534600003570651000152-s2.0-84930750395