Alpaydin, SertacTuran, YasarCaliskan, MustafaCaliskan, ZuhalAksu, FeyzaOzyildirim, SerhanBuyukterzi, ZaferKostek, OsmanMuderrisoglu, Haldun2023-06-052023-06-0520171359-5237http://hdl.handle.net/11727/9336Objective Morning blood pressure (BP) surge (MBPS) is defined as an excessive increase in the morning BP from the lowest systolic BP during sleep and is reported as a risk factor for cardiovascular events in current clinical studies. In this study, we aimed to investigate the relationship between MBPS and carotid intima-media thickness (C-IMT) in prehypertensive patients. Patients and methods We evaluated the association between the rate of BP variation derived from ambulatory BP monitoring and C-IMT in patients with prehypertension. Results One hundred and seventy patients with prehypertension were included in the study. All office BP measurements and ambulatory 24-h, day-time, and night-time measurements were similar between each group. C-IMT [0.60 (range: 0.57-0.65) vs. 0.55 (range: 0.50-0.60) cm; P < 0.001] and the mean platelet volume [8.7 (range: 7.9-9.1) vs. 7.9 (range: 7.3-8.8) fl; P = 0.002] were significantly higher in the greater MBPS group than the lower group. In multivariate analysis, male sex [odds ratio (OR): 2.271, confidence interval (CI): 1.011-5.100, P = 0.047], greater MBPS (OR: 8.474, CI: 3.623-19.608, P < 0.001), and elevated mean platelet volume levels (OR: 3.359, CI: 1.978-5.705, P < 0.001) were found to be independent predictors of greater C-IMT in prehypertensive patients. Conclusion Our study suggests that greater MBPS is associated independently with C-IMT in prehypertensive patients. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.enginfo:eu-repo/semantics/closedAccessambulatory blood pressure monitoringblood pressurecardiovascular riskcarotid intima-media thicknessmean platelet volumemorning blood pressure surgearticle2231311360004004785000032-s2.0-85014647558