Ozcan, D.Seckin, D.2023-07-172023-07-1720160926-9959http://hdl.handle.net/11727/9929BackgroundThe management of trichotillomania is challenging. The limited efficacy and side-effects of pharmacological medications and difficulty in long-term maintenance of behavioural therapies necessitates alternative treatment options. A dysregulated glutamatergic system has been implicated in the pathophysiology of trichotillomania. A limited number of reports indicate that N-acetylcysteine (NAC), a glutamate modulator, may be a promising treatment for this disorder. ObjectivesWe report two patients with trichotillomania for whom treatment with NAC was successful. MethodsThe first patient was a 30-year-old female, and the second patient was a 14-year-old girl, both who were diagnosed with trichotillomania and prescribed NAC (1200 mg/d, p.o.). ResultsHair pulling behaviour subsided within 2 months and 2 weeks of initiating NAC in the first and second patient, respectively. Complete hair regrowth was observed after 4 and 6 months of NAC treatment in the first and second patient, respectively. No side-effects related to NAC were noted. ConclusionNAC could be a well-tolerated and effective treatment option for trichotillomania.enginfo:eu-repo/semantics/closedAccessOBSESSIVE-COMPULSIVE DISORDERACETYL-CYSTEINEPEDIATRIC TRICHOTILLOMANIAGROOMING DISORDERSDOUBLE-BLINDArticle309160616080003836053000272-s2.0-849830848921468-3083