Yirgin, İnci KizildagHas, DuyguArslan, GozdeAydin, Esra CureogluSari, MuratOnder, SemenYasemin, SanliCabioglu, NeslihanKaranlik, HasanTukenmez, MustafaDursun, MemduhMuslumanoglu, MahmutOzmen, Vahit2021-03-302021-03-302020https://www.ejropen.com/article/S2352-0477(20)30075-7/pdfhttp://hdl.handle.net/11727/5633Purpose: To compare the adipose and muscle tissue areas in patients who responded differently to neoadjuvant chemotherapy. Methods: One hundred and eighty six patients diagnosed with breast cancer who underwent neoadjuvant chemotherapy between January 2015- October 2019 and were operated after the treatment were retrospectively included in the study. Pathological results were divided into five groups using the Miller-Payne grading systems. Grade 1 indicating no significant reduction in malignant cells; Grade 2: a minor loss of malignant cells (<= 30 %); Grade 3: reduction in malignant cells between 30 % and 90 %; Grade 4: disappearance of malignant cells >90 %; Grade 5: no malignant cells identifiable. Pre-treatment PET CT scans were evaluated, and calculation of body composition parameters were performed on a single axial section passing through the L3 vertebrae. Spearman's correlation test was used to analyze the correlation between SAT, VAT, MT parameters and pathological responses. Results: There was no strong correlation between the 5 groups separated according to neoadjuvant chemotherapy treatment response and tissue distributions. However, that there was a very low correlation found between superficial adipose tissue and pathological response (r=, 156). Conclusion: In conclusion, our results have provided a very low correlation between SAT and more than 30 % response. More research is required to evaluate the role of the body fat and muscle parameters in response to neoadjuvant chemotherapy in larger patient populations.enginfo:eu-repo/semantics/openAccessAdipose tissueBody composition parameterBreast cancerComputed tomographyarticle70006005974000752-s2.0-850971493212352-0477