Verdi, HasibeKinik, Sibel TulgarYalcin, Yaprak YilmazSahin, Nursel MuratogluYazici, Ayse CananAtac, F.Belgin2019-12-062019-12-0620151308-5727http://cms.galenos.com.tr/Uploads/Article_1272/7-12.pdfhttp://hdl.handle.net/11727/4332Objective: In this study, we aimed to investigate the association of W64R polymorphism of the beta 3-adrenergic receptor gene (beta-3AR) with childhood obesity and related pathologies. Methods: beta-3AR gene W64R genotyping was carried out in 251 children aged 6-18 years. Of these subjects, 130 were obese (62 boys) and 121 were normal-weight (53 boys). In the obese group, fasting lipids, glucose and insulin levels were measured. Oral glucose tolerance test (OGTT) was performed in 75 of the obese patients. Results: The frequency of W64R genotype was similar in obese and nonobese children. In obese children, relative body mass index, waist-to-hip ratio, serum lipid, glucose and insulin levels, as well as homeostasis model assessment of insulin resistance (HOMA-IR) scores were not different between Arg allele carriers (W64R and R64R) and noncarriers (W64W). In 75 obese children, OGTT results showed that Arg allele carriers had significantly higher 30-minute glucose levels (p=0.027). Conclusion: W64R polymorphism of the beta-3AR gene is not associated with obesity and waist-to-hip ratio in Turkish children. Although there were no relationships between the genotypes and lipid, glucose/insulin levels or HOMA-IR, the presence of W64R variant seemed to have an unfavorable influence on early glucose excursion after glucose loading.enginfo:eu-repo/semantics/openAccessObesitychildrenbeta 3-adrenergic receptor gene polymorphismoral glucose tolerance testarticle717120003513072000022-s2.0-84925446286