Yalcin, IbrahimSahin, HanifiSari, Mustafa ErkanHaberal, Asuman NihanSahin, Eda AdeviyeCelik, HusnuMeydanli, Mehmet MutluAyhan, Ali2022-09-062022-09-0620212363-8397https://link.springer.com/content/pdf/10.1007/s40944-021-00559-z.pdfhttp://hdl.handle.net/11727/7537Purpose To compare the prognoses of women with high-grade ovarian carcinoma arising in endometriosis (OCAE) to those of women with ovarian high-grade serous carcinoma (HGSC) Material and Methods This multicenter, retrospective, case-control study included patients with OCAE at two gynecologic oncology centers in Turkey between January 2006 and December 2016. Of a total of 202 women with a diagnosis of OCAE, 70 women with high-grade OCAE were included. Each case high-grade OCAE was attributed to two women with ovarian HGSC. Survival analysis was performed using the Kaplan-Meier method. Results Eleven patients with high-grade OCAE had recurrent disease (15.7%) when compared to 47 patients (33.6%) with HGSC (p = 0.008). The 5-year disease-free survival (DFS) rate of the patients having high-grade OCAE was significantly higher than the women with HGSC (78.3% vs. 56.2%; p = 0.007, respectively). According to the 5-year overall survival (OS) rates, there was no significant difference between high-grade OCAE and HGSC (79.5% vs. 70.1%; p = 0.210, respectively). Conclusion Although this retrospective study demonstrated a significant decrease in recurrence rate and an increase in the 5-year DFS rate in patients with high-grade OCAE, OS rates of the patients with HGSC and high-grade OCAE seem to be similar.enginfo:eu-repo/semantics/closedAccessEndometriosisHigh-grade serous ovarian carcinomaOvarian endometrioid carcinomaOvarian clear cell carcinomaSurvival analysisarticle1940006698768000012-s2.0-85110492082