Walsh, Kyle B.Toledo-Pereyra, Luis H.Lopez-Neblina, FernandoRivera-Chavez, Fernando A.Toledo, Alexander H.2025-12-082009-06Experimental and Clinical Transplantation, Cilt, 7, Sayı, 2, 2009 ss. 78-931304-0855https://hdl.handle.net/11727/14074Liver ischemia and reperfusion — which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) — have been the focus of many investigations in recent years. Although the mechanisms of ischemia-reperfusion injury are numerous and complex, many advances in treatment have been made. The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. To provide a unique analysis and evaluation, we emphasized the most recent pertinent investigations of the last decade. Specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, T cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines.en-USIschemia and ReperfusionInflammatory mediatorsLiverTransplantTraumaArticle722146-8427