Makay, OzerIsik, DilekErol, VarlikYenisey, CigdemKose, TimurIcoz, GokhanErtan, YesimOzutemiz, OmerAkyildiz, Mahir2023-07-212023-07-2120170001-5458http://hdl.handle.net/11727/10023Background: We aimed to investigate whether simvastatin had any impact on the prevention of adhesion formation after thyroidectomy in a rat model. Methods: This study was performed in 66 Wistar albino rats randomized into three experimental groups. A right hemithyroidectomy was carried out in all the rats. Simvastatin was administered locally at a dose of 0.5 mg/kg and 0.8 mg/kg. Control rats received a saline solution only. Changes during the 1st week, 1st month and 3rd month were evaluated. Efficacy of the treatment was assessed by using a scoring system. Results: The severity of adhesions in low-dose simvastatin group was significantly less than the control and high-dose groups during the 1st and 3rd month (p <. 05). In addition, adhesions were less in the high dose group during the 3rd month, when compared to the control group (p <. 05). Moreover, fibrosis and fibroblast scores, which represent adhesions, were significantly lower in low-dose and high-dose groups at 3rd month, compared to controls (p <. 05). Conclusions: We investigated the influence of simvastatin application on post-thyroidectomy adhesion formation in rats. Whether adhesions, causing technical difficulties during neck redo surgery, can be reduced by the use of simvastatin in human, needs to be studied.enginfo:eu-repo/semantics/closedAccessHead and neckendocrinethyroid surgeryarticle117277830003966492000022-s2.0-85014758756