Abdulaziz FayazovKhuriya MukhitdinovaAkmal MirzakulovKhikmat Anvarov2025-06-102021-06Burn Care & Prevention, cilt 1, sayı 2, ss. 60-64https://hdl.handle.net/11727/13301OBJECTIVES:In this study, our objective was to study the features of infusion therapy during the period of toxemia of burn disease in adults. MATERIALS AND METHODS: Results of moni­toring of the daily volume of injected fluid, infusion therapy, and renal excretory activity of 25 patients were studied. All patients had been admitted to the Department of Combustiology in the Republican Research Center of Emergency Medicine (Tashkent, Uzbekistan) because of burn injury. After recovery from shock, all patients received the following treatments: anti-inflammatory agents, antibacterial therapy, correction of protein and water-electrolyte balance disorders, early surgery, delayed necrectomy, addi-tional parenteral nutrition, and syndrome- and symptom-specific therapy. All para­meters were compared and studied among 3 age groups: group 1 consisted of 12 patients from 20 to 40 years old (average 27.3 ± 5.6 years), group 2 consisted of 7 patients from 41 to 60 years old (average 50.7 ± 7.1 years), and group 3 consisted of 6 patients from 61 to 78 years old (average 71.3 ± 7.0 years). RESULTS: The average daily volume of infusion therapy in group 1 (Frank index 119.4 ± 38.4 U) was 76 ± 7 mL/kg/day; in group 2 (Frank index 92.5 ± 20.8 U), daily administration was 64 ± 9 mL/kg/day; and in group 3 (Frank index 86.7 ± 12.8 U), daily administration was 48 ± 11 mL/kg/day. CONCLUSIONS: In the fluctuating nature of changes in intravenous infusion, which may occur over 4 to 5 days, there are a number of factors that determine the need to increase or decrease infusion therapy. During the period of toxemia, the hourly renal excretory activity was most evident in patients in group 1, corresponding to a greater volume of water load and severity of burn injury. In group 2, which had average infusion therapy of 64 ± 9 mL/kg/day, preclinical signs of overload in pulmonary circulation were shown.en-USCoagulationCombustiologyFrank indexThermal damageToxemiaArticlecilt 1sayı 2