Soydan, Sidika SinemUckan, Sina2024-03-192024-03-1920140278-2391http://hdl.handle.net/11727/11867Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication resulting from the long-term application of bisphosphonates. In most cases, BRONJ occurs after a surgical procedure involving the jawbone. Currently, the management of BRONJ remains controversial, and there is no definitive treatment other than palliative methods. Platelet-rich fibrin (PRF) represents a relatively new biotechnology for the stimulation and acceleration of tissue healing and bone regeneration. This technical note describes the total closure of moderate bone exposure in persistent BRONJ in 2 weeks with a double-layer PRF membrane. PRF may stimulate gingival healing and act as a barrier membrane between the alveolar bone and the oral cavity. PRF may offer a fast, easy, and effective alternative method for the closure of bone exposure in BRONJ. (C) 2014 American Association of Oral and Maxillofacial Surgeonsenginfo:eu-repo/semantics/closedAccessPRFFIBROBLASTSarticle7223223260003297565000182-s2.0-84892587335