Oter, B. I.Tirali, R. E.Ozgul, B. M.Berk, N.Cehreli, S. B.2023-06-082023-06-0820171591-996Xhttp://hdl.handle.net/11727/9453Aim This study investigated the effect of laser pretreatment in reducing the microleakage of conventional (GIC) and resin-modified glass ionomer (RMGIC) sealants on saliva-contaminated enamel. Materials and methods Study Design: 80 extracted non-carious third molars were randomly assigned to two groups (n=40/each): Group A enamel pretreatment with erbium, chromium:yttrium, scandium, gallium, garnet (Er,Cr:YSGG) laser; and Group B no pretreatment. Each group was divided into two subgroups (n=20/each) based on presence/absence of saliva contamination following laser pretreatment. In subgroups: fissures were sealed with GIC (n=10) or RMGIC (n=10). Microleakage was evaluated quantitatively using an image analysis toolkit (Image]), and the data were statistically analysed. Results In the absence of laser pretreatment, the GIC sealant demonstrated significantly lower microleakage values than RMGIC counterparts on both uncontaminated and saliva-contaminated enamel (p<0.001, Mann-Whitney U test). Conclusion Among the tested combinations, GIC sealant with Er,Cr:YSGG pretreatment may be the best approach for sealing pits and fissures, when saliva contamination is inevitable before sealant application.enginfo:eu-repo/semantics/closedAccessAtraumatic restorative technique (ART)Fissure sealantGlass ionomerLaser pretreatmentMicroleakageSealantsArticle1832262300004126202000102-s2.0-85036530751