Hayashi, MichihiroTanigawa, NobuhikoHaga, HironoriTakeshita, AtsushiAsakuma, MitsuhiroHirokawa, FumitoshiTsunematsu, IchiroShimizu, Tetsunosuke2026-04-012011-04Experimental and Clinical Transplantation, Cilt, 9, Sayı, 2, 2011 ss. 150-1521304-0855https://hdl.handle.net/11727/14719Late-onset hepatic failure, the least of the fulminant hepatic failures, has not occurred in patients with hepatitis A virus-related acute liver failure. We report a rare case of hepatitis A virus-related late-onset hepatic failure treated successfully by an emergent liver transplant. A 58-year-old Japanese woman who presented with fever and general malaise was diagnosed as having jaundice and liver dysfunction by a positive serum test for anti-hepatitis A virus IgM, which ultimately led to a diagnosis of acute hepatitis A virus-associated hepatitis. Despite intensive treatment, her general condition was poor, and she developed a hepatic coma 79 days from the onset of the disease. Under a diagnosis of hepatitis A virus-related late-onset hepatic failure, she was given a living-donor liver transplant 82 days from the start of the disease. The resected native liver revealed submassive necrosis with marked cholestasis, compatible with late-onset hepatic failure. Today, 5 years after the transplant, she is alive and well with no signs of recurrent hepatitis A virus-hepatitis. This case should alert the physician to the clinical management of a patient with hepatitis A virus-related acute liver failure.enHepatitis A virusFulminant hepatic failureLate onset hepatic failureLiver transplantCase Report922146-8427