Keskin, Gul SemaHelvaci, OzantYayla, CagriPasaoglu, Ozge T.Keskin, CaglarArinsoy, TurgayDeric, Ulver B.2021-02-282021-02-2820191300-0144https://journals.tubitak.gov.tr/medical/issues/sag-19-49-1/sag-49-1-21-1804-169.pdfhttp://hdl.handle.net/11727/5445Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.enginfo:eu-repo/semantics/openAccessYKL-40CKDhemodialysisatherosclerosisendothelial dysfunctionarticle4911391460004583670000202-s2.0-85061564678