Kayar, Nezahat ArzuUstun, KemalGozlu, MuammerHaliloglu, SeyfullahAlptekin, Nilgun Ozlem2022-09-142022-09-1420211432-6981http://hdl.handle.net/11727/7745Objective Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS). In this study, we explored the effect of non-surgical periodontal treatment (NSPT) on cardiovascular blood biomarkers and gingival crevicular fluid (GCF) neutrophil elastase (NE) and alpha 1-proteinase inhibitor (alpha-1PI) levels in periodontitis (P) participants with and without ACS. Materials and methods Medical and dental examinations were performed to diagnose ACS and periodontitis, respectively. Seventeen patients with diagnosis of ACS and periodontitis were included in this study, as a test group (group ACS). Twenty-six age and sex-matched control patients with periodontitis (group P) were otherwise systemically healthy. Both groups received NSPT. Plasma levels of cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP), GCF NE activity, GCF alpha(1)-PI levels, and GCF NE/alpha 1-PI rates were measured at baseline, at1(st) and 3(rd) months after NSPT. Results GCF NE activity/time (mu U/30s) decreased significantly at 3(rd) month compared to baseline values in the Group P after NSPT. First and 3(rd) months after NSPT, in the Group P GCF alpha(1)-PI activity/time (pg/30s) was significantly higher than the Group ACS. Moreover GCF NE/alpha(1)-PI rates decreased significantly compared to baseline values at 1(st) and 3(rd) months after NSPT in the group P. Conclusion NSPT yields decrease in NE/alpha(1)-PI rates. NE and its possible interactions with alpha(1)-PI may play a crucial role in both periodontitis and ACS. GCF alpha 1PI activity/time (U/30s) can be a potential biomarker in management of periodontitis associated with ACS.enginfo:eu-repo/semantics/closedAccessNon-surgical periodontal therapyAcute coronary syndromeNeutrophil elastaseAlpha-1 proteinase inhibitorarticle255332933380006267892000022-s2.0-85102349685