Aydin, M.Ergonul, O.Azap, A.Bilgin, H.Aydin, G.Cavus, S. A.Demiroglu, Y. Z.Aliskan, H. E.Memikoglu, O.Menekse, S.Kaya, S.Demir, N. A.Karaoglan, I.Basaran, S.Hatipoglu, C.Erdinc, S.Yilmaz, E.Tumturk, A.Tezer, Y.Demirkaya, H.Cakar, S. E.Keske, S.Tekin, S.Yardimci, C.Karakoc, C.Ergen, P.Azap, O.Mulazimoglu, L.Ural, O.Can, F.Akalin, H.2023-04-192023-04-1920180195-6701http://hdl.handle.net/11727/8838This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.enginfo:eu-repo/semantics/closedAccessBloodstreamGram-negativeHealth careColistin MICarticle9832602630004263167000112-s2.0-85044363955