Honarbakhsh, NazaninGholami, KheirollahMohebbi, NiayeshJavadi, Mohammad RezaLesan-Pezeshki, MahboobRouini, Mohammad RezaKarimzadeh, Iman2026-05-072013-04Experimental and Clinical Transplantation, Cilt, 11, Sayı, 2, 2013 ss. 112-1171304-0855https://hdl.handle.net/11727/15005Objectives: To determine the mycophenolic acid pharmacokinetic profile early after transplant in Iranian kidney graft recipients. Materials and Methods: A cross-sectional study was performed during 6 months in 31 patients who recently had kidney transplant and received fixed doses of mycophenolate mofetil (2 g/d). The plasma levels of mycophenolic acid were determined by high performance liquid chromatography. Results: The mean first mycophenolic acid peak level was 10 ± 5 mg/L. The mean mycophenolic acid area under the curve was 26 ± 19 mgh/L and apparent clearance was 57 ± 55 L/h. The mycophenolic acid area under the curve values of only 8 patients (26%) were within the therapeutic range (30-60 mgh/L). The first, second, and third mycophenolic acid peak levels correlated significantly with mycophenolic acid area under the curve (P < .05). Mycophenolic acid concentration at 10 hours had the highest correlation with mycophenolic acid area under the curve (r=0.962; P < .05). No statistically significant differences were evident in the mean mycophenolic acid area under the curve between men and women. Conclusions: There was a high degree of variation between different patients in mycophenolic acid pharmacokinetics early after kidney transplant.enAllograftRenalRejectionImmunosuppressionMycophenolate mofetilArticle1122146-8427