Saygi, SemraErol, IlknurAlehan, FusunYalcin, Yaprak YilmazKubat, GozdeAtac, Atac, Fatma Belgin2023-12-212023-12-2120150883-0738http://hdl.handle.net/11727/11163This study compared superoxide dismutase (SOD) and catalase (CAT) alleles in 97 consecutive children and adolescents with migraine to 96 healthy children and adolescents. Isolated genomic DNA was used as a template for SOD1 (35 A/C), SOD2 16 C/T, and CAT2 [(-262 C/T) and (-21 A/T)] allele genotyping. The SOD2 16 C/T genotype and C allele frequency differed significantly between controls and migraine (P = .047; P = .038). CAT -21 AA genotype and A allele frequency were significantly higher in both migraine with aura patients (P = .013; P = .004) and migraine without aura patients (P = .003; P = .001) compared to controls. To our knowledge, this is the first demonstration of differences in SOD and CAT genotypes between pediatric migraine patients and age-matched controls. Further studies on the functional implications of these genetic variants on neural antioxidant capacity and the use of antioxidant modulators for migraine treatment are warranted.enginfo:eu-repo/semantics/closedAccesssuperoxide dismutasescatalasemigraineoxidative stresschildrengene polymorphismArticle3012158615900003616325000052-s2.0-849420890771708-8283