Rohrbach, Daniel J.Salem, HakeemAksahin, MehmetSunar, Ulas2019-08-022019-08-0220162304-6732https://www.mdpi.com/2304-6732/3/3/48http://hdl.handle.net/11727/3794One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response.enginfo:eu-repo/semantics/openAccessskin cancermicrovasculaturephotoacoustic microscopyblood flowphotodynamic therapyArticle330003818604000082-s2.0-85013224002