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Item A Local Search Heuristic with Self-tuning Parameter for Permutation Flow-Shop Scheduling Problem(2009) Dengiz, Berna; Alabas-Uslu, Cigdem; Sabuncuoglu, IhsanIn this paper, a new local search metaheuristic is proposed for the permutation flow-shop scheduling problem. In general, metaheuristics are widely used to solve this problem due to its NP-completeness. Although these heuristics are quite effective to solve the problem, they suffer from the need to optimize parameters. The proposed heuristic, named STLS, has a single self-tuning parameter which is calculated and updated dynamically based on both the response surface information of the problem field and the performance measure of the method throughout the search process. Especially, application simplicity of the algorithm is attractive for the users. Results of the experimental study show that STLS generates high quality solutions and outperforms the basic tabu search, simulated annealing, and record-to-record travel algorithms which are well-known local search based metaheuristics.Item How hematopoietic stem cell transplantation activity was affected during the pandemic? JACIE accredited center reflex(2022) Kozanoglu, I.; Tepebasi, S.; Kursun, E.; Sen, N.; Unsal, Z. E.; Kis, C.; Boga, C.; Yesilagac, H.; Demiroglu, Y. Z.; Pocan, G.Item TBI/fludarabine versus busulfan/fludarabine as a myeloablative conditioning for adults with acute myeloid leukemia treated with allo-HCT. A study from the ALWP of the EBMT(2022) Swoboda, R.; Labopin, M.; Giebel, S.; Schroeder, T.; Kroeger, N.; Arat, M.; Savani, B.; Spyridonidis, A.; Hamladji, R. M.; Potter, V.; Deconinck, E.; Yakoub-Agha, I.; Rambaldi, A.; Ozdogu, H.; Sanz, J.; Nagler, A.; Mohty, M.Item Traveling Repairmen Problem: A Biogeography-Based Optimization(2022) Uzun, Gozde Onder; Dengiz, Berna; Kara, Imdat; Karasan, Oya EkinTraveling Repairman Problem (TRP), which is also known by names cumulative traveling salesman problem, the deliveryman problem and the minimum latency problem, is a special variant of Traveling Salesman Problem (TSP). In contrast to the minimization of completion time objective of TSP, the desired objective of TRP is to minimize the cumulative latency (waiting time or delay time) of all customers. In this paper, a generalized version of TRP with multi depots and time windows, namely Multi Depot Traveling Repairman Problem with Time Windows (MDTRPTW) is considered. A group of homogeneous repairmen initiate and finish their visit tours at multiple depots. Each customer must be visited exactly by one repairman within their provided earliest end latest times. Being a challenging Nondeterministic Polynomial-hard (NP-hard) optimization problem, exact solution approaches are not expected to scale to realistic dimensions of MDTRPTW. Thus, we propose a biogeography-based optimization algorithm (BBOA) as a metaheuristic approach to solve large size MDTRPTW problems. The proposed metaheuristic is analyzed in terms of solution quality, coefficient of variation as well as computation time by solving some test problems adapted from the related literature. The efficacy of the proposed solution methodology is demonstrated by solving instances with 288 customers within seconds.Item The Inventory of Flood Disasters in Turkey(2022) Gurer, Ibrahim; Ucar, IbrahimTurkey is located both Europe and Asia, and covers an area of 780 580 km(2) including the lakes. Turkey undergoes different types of natural disasters because of its geographical location, geomorphology, and topography. Flooding is the second important natural hazard after earthquakes. A flood inventory of the period extending from 1955 to 2020 having a total of about 3250 events was prepared using a simple computer program based on Excel for easy access to different geomorphologic parameters such as surface areas of river basins, slope, geological structure, vegetative cover, type of precipitation, and the elevation above mean sea level (a.m.s.l) and hydro-meteorological parameters. In the same inventory each flood has been defined with damages on human as lost and injured, size of flooded area and loss of wealth (not exact information for wealth). By categorization of the available data in hand, spatial and time distributions of past flood events were determined. In large basins, negative impacts are more closely related to climatic factors, but in small watersheds, the urbanization along the rivers, internal migration, regional planning, urban drainage infrastructure are more important on negative impacts. In order to prevent the floods and minimize the adverse effects to property, both structural and non-structural solutions are applied in Turkey. Two case studies added to show the solutions.Item Hydropower Outlook of Turkey in 2021(2022) Gurer, IbrahimTurkey is located partly on Europe and also on Asia, and has a surface area of 780 580 km(2) and a population of 84.6 million and electric energy is essential for the everyday life. The annual per capita consumption of electricity is mainly used to measure the prosperity of a nation. The energy use in a country increases not only with population increase but also by improving the living standards of people and industrial development. Turkey being a non-oil-producing country at present, therefore needs to import fossil fuels (like natural gas and fuel oil) as the main source of electric energy. The utilization of fossil fuels for energy production by thermal power plants is one of the main sources of air pollution. The consumption of imported energy sources should be reduced for the environmental, economic, and political reasons. As the electricity need of the country is increasing continuously, more energy from the renewables and national resources must be produced. Hydropower plants (HPPs) provide clean, fast, flexible electricity generation. The amount of electricity that aHPP can produce basically depends on the available flow rate (Q) and the head (H). Very briefly the greater the flow rate and the net head, the more electricity can be produced in a HPP. The first hydropower station of Turkey had been opened at Tarsus town in 1929. Number of hydropower installations and total installed capacity has increased especially after the 1960s. In 2020, the Turkish electric production values were 32.9% from HPPs, 27.2% from thermal plants working with natural gas, 21.3% from thermal plants working with coal, 8.8% fromwind power plants, 6.8% from the sun, 1.6% from geothermal plants, and about 1.4% from other types of sources. Technically and economically feasible total hydroelectric energy potential of Turkey is 180 billion kWh/year, of which 160 billion kWh/year has been developed and completed. With 714 completed facilities and 31,391 MW installed power and 108.0 billion kWh/year of it has been put into operation. With the projects to be established until 2023, a total installed power capacity of 40,000 MW and a generation potential of 135 billion kWh/year will be reached. Because of the very fast increase in energy consumption, and only 22% of total energy is produced from national sources, and 125 billion dollars total investment is needed. Due to the climate change, and the change in the oil prices, the renewable sources such as solar, wind, geothermal, biogas, biomass, hydropower etc. should be developed and put in service as quickly and efficiently as possible. In this paper, the current level of hydropower production and energy saving, and power consumption by different sectors, and the subject matter of the most recent energy figures are given and the future projections are also presented.Item Individual Factors Leading To Delay In Diagnosis In Patients With Colorectal Cancer And Their Illness Perceptions(2022) Tanrikulu, U. Ege; Kav, S.Item Patient-Reported Outcomes (Pros) Of Cemiplimab Vs Chemotherapy In Advanced Non-Small Cell Lung Cancer (Ansclc): EMPOWER-Lung 1 Histology Subgroups(2022) Sezer, A.; Kilickap, S.; Gumus, M.; Bondarenko, I.; Ozguroglu, M.; Gogishvili, M.; He, X.; Gullo, G.; Rietschel, P.; Quek, R.Item Three Years Survival Outcome And Continued Cemiplimab (CEMI) Beyond Progression With The Addition Of Chemotherapy (Chemo) For Patients (Pts) With Advanced Non-Small Cell Lung Cancer (NSCLC): The EMPOWER-Lung 1 Trial(2022) Ozguroglu, M.; Kilickap, S.; Sezer, A.; Gumus, M.; Bondarenko, I.; Gogishvili, M.; Nechaeva, M.; Schenker, M.; Cicin, I.; Ho, G. F.; Kulyaba, Y.; Dvorkin, M.; Zyuhal, K.; Scheusan, R. I.; Li, S.; Pouliot, J-F.; Seebach, F.; Lowy, I.; Gullo, G.; Rietschel, P.Item ENGOT-Ov65/KEYNOTE-B96: Phase III, Randomized, Double-Blind Study Of Pembrolizumab Vs Placebo Plus Paclitaxel With Optional Bevacizumab For Platinum-Resistant Recurrent Ovarian Cancer(2022) Colombo, N.; Coleman, R. L.; Wu, X.; Kose, F.; Wenham, R.; Sebastianelli, A.; Hasegawa, K.; Zsiros, E.; Rouge, T. De La Motte; Bidzinski, M.; McNeish, I.; Sehouli, J.; Korach, J.; Debruyne, P. R.; Kim, J-W.; De Melo, A. C.; Peng, X.; Bogusz, A. M.; Yamada, K.; Monk, B. J.