Browsing by Author "Rzayev, Zakir M. O."

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Ag-Carried CMC/Functional Copolymer/ODA-Mt Wled-Treated NC And Their Responses to Brain Cancer Cells
(2018) Rzayev, Zakir M. O.; Bunyatova, Ulviye; Lovell, Jonathan F.; Shen, Weipeng; Thomay, Tim; Cartwright, Alexander; 0000-0002-9705-1722; 30184772; J-5194-2019
The subject of this work is synthesis and characterization of novel multifunctional nanocomposite (8/2A-NC) consisting (1) carboxymethyl cellulose (CMC) as a matrix biopolymer and poly (maleic acid-tilt-acrylic acid) as a reactive synthetic partner matrix polymer; (2) octadecyl amine montmorillonite (ODA-MMT) reactive organoclay provide intercalated silicate layers structures and aqueous colloidal dispersing medium, and MMT as carriers and targeting agents for anticancer agents in drug delivery systems, respectively. ODA as a intercalated surfactant finely dispersed 8/2A NC and its compatibility with matrix polymers via the interfacial polarization (complexing) and functionalization of matrix polymers by amine (ODA) and carboxylic acids from both the CMC and copolymer; (3) silver nanoparticles (AgNPs) as in-situ generated onto matrix polymers with unique nano-size and morphology parameters was synthesized. Important material science and bioengineering aspects of these investigations included (a) novel approach in synthetic pathways; (b) effects of physical and chemical structural rearrangements; (c) effects of Light Emitting Dioda (LED)-treatment on the FT-IR spectra, XRD reflection parameters, SEM-TEM morphology and nano-size and diameter distribution of AgNPs onto matrix polymers; (d) positive effect of LED-treatment of 8/2A nanocomposite and its response to the MIAPaCa-2 and U87 human brain cancer cell lines were evaluated. Novel 8/2A-NC multifunctional drug consisting unique positive, intercalating and encapsulated core-shell morphology structures, nano-size (5.6 run) and narrow diameter distribution (94%) of AgNPs onto matrix polymers [silver NPs (0.25%) in 8/2A NC (25%)] with highest volume of contact area compared with used cancer micro-cells show lowest cell viability as an excellent anticancer platform. 8/2A-NC is a novel multifunctional drug with intercalating and encapsulated core-shell morphology structures consisting of positively charged, non-randomly distributed AgNPs with a large contact area and low diameters (5-6 nm). The anticancer properties of (This factor is not conformed experimentally in work) this drug can be explained by the following structural factors: 8/2A-NC contains a combination of active sites from protonated hydroxyl, carboxyl and amine groups; Ag + -cations and ODA-MMT with high physical and chemical surface areas. We suggest this material be further explored for anti-cancer testing.
Fabrication and Characterization of PVA/ODA-MMT-Poly(MA-Alt-1-Octadecene)-G-Graphene Oxide E-Spun Nanofiber Electrolytes and Their Response to Bone Cancer Cells
(2016) Rzayev, Zakir M. O.; Salimi, Kouroush; Bunyatova, Ulviya; Acar, Selim; Salamov, Bahtiyar; Turk, Mustafa; 26838849; J-5194-2019
This work presents a new approach to fabrication and characterization of novel polymer nanofiber electrolytes from intercalated PVA/ODA-MMT nanocomposite as a matrix polymer and encapsulated graphene oxide (GO) nanosheets with amphiphilic reactive copolymer as partner polymers using electrospinning method. The chemical and physical structures, surface morphology, thermal behaviors and electric conductivity of nanocomposites and nanofibers were investigated using analyses methods including FTIR, XRD, SEM, DSC-TGA and conductivity analysis. Significant improvements in nanofiber morphology and size distribution were observed when GO and reactive organoclay were incorporated as reinforcement fillers into various matrix/partner solution blends. The structural factors of matrix-partner polymer nanocomposite particles with higher zeta-potential play important roles in both chemical and physical interfacial interactions and phase separation processing and also lead to the formation of nanofibers with unique surface morphologies and good conductivities. The cytotoxic, necrotic and apoptotic effects of chosen nanofibers on osteocarcinoma cells were also investigated. These multifunctional, self-assembled, nanofibrous surfaces can serve as semi-conductive and bioactive platforms in various electrochemical and bio-engineering processes, as well as reactive matrices used for the immobilization of various biopolymer pfecursors. (C) 2015 Elsevier B.V. All rights reserved.
Functional Copolymer/Organo-MMT Nanoarchitectures. XXII. Fabrication and Characterization of Antifungal and Antibacterial Poly (Vinyl Alcohol-co-Vinyl Acetate/ODA-MMT/AgNPs Nanofibers and Nanocoatings by e-Spinning and c-Spinning Methods
(2015) Rzayev, Zakir M. O.; Erdonmez, Demet; Erkan, Kubra; Simsek, Murat; Bunyatova, Ulviye; 0000-0002-2904-3587
Nanofibrous films and coatings were fabricated by electrospinning and centrifugal spinning of aqueous solutions of poly(vinyl alcohol-co-vinyl acetate)/octadecyl amine-montmorillonite layered silicate nanocomposites with/without in situ generated silver nanoparticles (AgNPs). Characterization of nanofibers were realized by FTIR, XRD, SEM, and thermal analysis methods. It was found that AgNPs significantly accelerated phase separation process providing fine distribution of nanofibers. Antifungal and antimicrobial activities of nanocomposites investigated by using Candida Spp fungals, G-positive and G-negative microorganisms strongly depended on chemical/physical structural factors, and loading silver species. Observed effective properties of nanomaterials can be employed for many applications (e.g., air filtration, food packaging, biomedical).
Functional Organo-Mt/Copolymer Nanoarchitectures. Microwave-Assisted Rapid Synthesis and Characterisation of ODA-Mt/poly[NIPAm-co-(MA-alt-2,3-2H-DHP)] Nanocomposites
(2015) Rzayev, Zakir M. O.; Uzgoren-Baran, Ayse; Bunyatova, Ulviye; 0000-0002-2904-3587
In this work, novel octadecyl amine-montmorillonite (ODA-Mt) copolymer nanocomposites were synthesised by interlamellar microwave-assisted complex-radical copolymerisation. The microwave method is found to be a facile and highly effective means to clay polymer nanocomposites (CPNs) that provide a higher rate of interlamellar copolymerisation and conversion of micro- and nanoparticles. The chemical and physical structures, surface morphologies and thermal behaviours of the prepared CPN were investigated by FTIR and H-1 (C-13) NMR spectroscopy, XRD, SEM, TEM, thermal (DSC and TGA) and dynamic mechanical (DMA) analysis methods. That copolymerisation was accompanied by in situ complex formation (charge transfer complex and H-bonding similar with known copolymerisation without ODA-Mt) and the intercalative amidisation of anhydride units with the octadecyl amine groups of Mt was determined. These observed chemical and physical interfacial interactions as effective in situ processing play an important role in the formation of hybrid systems and micro- and nanocomposites with stimuli-responsive NIPAm polymer chains. (C) 2014 Elsevier B.V. All rights reserved.
Multifunctional Colloidal Nanofiber Composites Including Dextran and Folic Acid As Electro-Active Platforms
(2017) Rzayev, Zakir M. O.; Bunyatova, Ulviye; Simsek, Murat; 28385251
This work presents the fabrication and characterization of novel colloidal multifunctional polymer nanofiber composites (NFCs) from water dispersion blends of intercalated silicate layered nanocomposites of poly (2-vinyl-N-pyrrolidone)/octadecyl amine-montmorillonite (ODA-MMT) and dextran/ODA-MMT as matrix and partner polymer intercalated nanocomposites in the presence of NaOH and folic acid (FA) as doping agents by green reactive electrospinning. Chemical and physical structures, surface morphology and electrical properties were investigated. Effects of matrix/partner polymer ratios, doping agents, absorption time of NaOH, and temperature on electrical parameters of NFCs were evaluated. The presence of FA and increasing dextran fraction in NFCs resulted in reducing fiber diameter and improving diameter distribution. High complexing behaviors of matrix/partner polymer chains, organoclay, FA, and NaOH significantly improved conductivity parameters, especially 5-min of absorption time (approximate to 10(-2)-10(-3) Sm-1). The conductivity of the samples decreased with increasing temperature. NFCs fabricated for the first time are promising candidates for various biomedical, electrochemical and electronic applications as electro-active platforms. (C) 2017 Elsevier Ltd. All rights reserved.
Novel Colloidal Nanofiber Electrolytes From PVA-Organoclay/Poly(MA-alt-MVE), and Their NaOH and Ag-Carrying Polymer Complexes
(2016) Simsek, Murat; Rzayev, Zakir M. O.; Acar, Selim; Salamov, Bahtiyar; Bunyatova, Ulviya; 2-s2.0-84956644446; J-5194-2019
Novel multifunctional polymer nanofiber electrolytes with covalence crosslinked structures from various solution blends of reactive intercalated poly(vinyl alcohol)/octadecylamine montmorillonite (as a matrix polymer), poly(maleic anhydride-alt-methyl vinyl ether) (as a partner polymer) and their NaOH-absorbing and Ag-carrying polymer complexes were fabricated via electrospinning. Chemical, physical, morphological, and electrical properties of nanofiber structures were investigated by FTIR, XRD, SEM, and electrical analysis methods. Ag precursors in fiber composites significantly improved phase separation processing, fiber morphologies, diameter distributions, and electrical properties of the fibers. In situ generation of Ag nanoparticles and their distribution on nanofiber surfaces during fiber formation occurred via complex formation between silver cations and electronegative functional groups from both matrix and partner polymers as stabilizing/reducing agents. Electrical resistance and conductivity strongly depended on matrix/partner polymer ratios and absorption time of NaOH solution on nanofibers. Addition of NaOH changed the electrical properties of fiber structures from almost dielectric state to excellent conductivity form. The fabricated unique nanofiber electrolytes are promising candidates for applications in power and fuel cell nanotechnology, electrochemical, and bioengineering processes as reactive semiconductive platforms. (C) 2015 Society of Plastics Engineers
Novel Colloidal Nanofiber Semiconductor Electrolytes from Solution Blends of PVA/ODA-MMT, Poly (Itaconic Anhydride-Alt-2-Vinyl-1,3-Dioxalan) and Its Ag-Carrying Polymer Complex by Reactive Electrospinning
(2016) Rzayev, Zakir M. O.; Simsek, Murat; Bunyatova, Ulviya; Salamovd, Bahtiyar; J-5194-2019
Colloidal polymer nanofibers as non-crystalline solid electrolytes were fabricated by using solution blends of polyvinyl alcohol/octadecyl amine-montmorillonite, alternating copolymer of itaconic anhydride with 2-vinyl-1,3-dioxalane and their Ag-carrying complexes by electrospinning. Chemical-physical structures, morphology, thermal and electrical properties of nanofiber electrolytes were investigated to evaluate their influences on the conductivity and resistance parameters. Successful chemical cross-linking of PVA matrix by reactive partner copolymer was observed via ring-opening esterification/cross-linking. A covalence bridge of partner copolymer between PVA macromolecules not only reinforced the network but also provided extra ion charged sites. Effects of alternating copolymer fraction, organoclay, in situ generated silver nanoparticles, and structural factors on the conductivity of nanofiber thin films were estimated. Conductivity and resistance parameters strongly depended on temperature, conduct time, morphology and in situ structural rearrangements during electrospinning. Addition of reactive organoclay and Agcarrying copolymer significantly improved the conductivity due to enhancing nanofiber structures with carboxylate ion charge sites. (C) 2015 Elsevier B.V. All rights reserved.
Novel Multifunctional Colloidal Carbohydrate Nanofiber Electrolytes with Excellent Conductivity and Responses to Bone Cancer Cells
(2015) Gokmen, Fatma Ozge; Rzayev, Zakir M. O.; Salimi, Kouroush; Bunyatova, Ulviya; Acar, Selim; Salamov, Bahtiyar; Turk, Mustafa; 26344321; J-5194-2019
This work presents a new approach to fabricating novel polymer nanofiber composites (NFCs) from water solution blends of PVA (hydrolyzed 89%)/ODA-MMT and Na-CMC/ODA-MMT nanocomposites as well as their folic acid (FA) incorporated modifications (NC-3-FA and NC-4-FA) through green electrospinning nanotechnology. The chemical and physical structures and surface morphology of the nanofiber composites were confirmed. Significant improvements in nanofiber morphology and size distribution of the NFC-3-FA and NFC-4-FA nanofibers with lower average means 110 and 113 nm compared with those of NFC-1/NFC-2 nanofibers (270 and 323 nm) were observed. The structural elements of polymer NFCs, particularly loaded partner NC-2, plays an important role in chemical and physical interfacial interactions, phase separation processing and enables the formation of nanofibers with unique morphology and excellent conductivity (NFC-3-FA 3.25 x 10(-9) S/cm and NFC-4-FA 8.33 x 10(-4) S/cm). This is attributed to the higher surface contact areas and multifunctional self-assembled supramacromolecular nanostructures of amorphous colloidal electrolytes. The anticancer activity of FA-containing nanofibers against osteocarcinoma cells were evaluated by cytotoxicity, apoptotic and necrotic analysis methods. (C) 2015 Elsevier Ltd. All rights reserved.