Browsing by Author "Ozdemir, B. Handan"

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The Age of the Recipient and the Ratio of CD4/CD8 in Renal Allografts Influences the Prognosis and the Presenting Time of the Polyoma Virus-Associated Nephropathy (PVAN)
(2022) Ozdemir, B. Handan; Akcay, Eda Yilmaz; Ozdemir, F. Nurhan; Baskin, Esra; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0001-6831-9585; AAJ-8097-2021; AAK-1960-2021
Association between focal adhesion kinase and matrix metalloproteinase-9 expression in prostate adenocarcinoma and their influence on the progression of prostatic adenocarcinoma
(2020) Atilgan, Alev Ok; Ozdemir, B. Handan; Akcay, Eda Yilmaz; Tepeoglu, Merih; Borcek, Pelin; Dirim, Ayhan; 0000-0002-7528-3557; 0000-0001-8595-8880; 0000-0002-9894-8005; 0000-0001-6831-9585; 0000-0003-2898-485X; 32106037; X-8540-2019; AAK-3333-2021; AAK-5222-2021; AAK-1960-2021; AAJ-5689-2021
Focal adhesion kinase (FAK), a member of the non-receptor cytoplasmic tyrosine kinase family, is associated with the development and progression of cancer. Matrix metalloproteinase-9 (MMP-9) is directly involved in the degradation of the extracellular matrix, and basement membrane components promote cancer cell migration and invasion. There is a functional interaction among FAK, MMP-9 and vascular endothelial growth factor (VEGF), which leads to enhanced cancer angiogenesis, cancer cell invasion and progression of malignancy. FAK, MMP-9, VEGF and CD34-positive microvessel density (MVD) were examined in 100 patients with prostate adenocarcinoma using immunohistochemistry. The relationship among these proteins and their impact on angiogenesis and clinicopathological parameters were also evaluated. The FAK expression was found to be positively correlated with the Gleason score, WHO grade group, tumour stage, extracapsular extension and perineural invasion. The MMP-9 expression was positively correlated with the WHO grade group, tumour stage, extracapsular extension, positive surgical margin and lymphovascular and perineural invasion. The FAK expression was also positively correlated with MMP-9 expression and MVD. However, no correlation between FAK and VEGF expression was identified. The MMP-9 expression was positively correlated with FAK expression and MVD. Strong MMP-9 expression was associated with shorter disease-free survival. These results suggest that strong MMP-9 and FAK expressions play an essential role in the progression of prostate adenocarcinoma. Further investigations should be conducted to determine the importance of these proteins as therapeutic targets for patients with prostate adenocarcinomas.
Baskent University Expanded Criteria for Hepatocellular Carcinoma: The Importance of the Histopathological Features as a Part of the Evaluation Criteria for Liver Transplantation
(2018) Ozgun, Gonca; Ozdemir, B. Handan; Moray, Gokhan; Reyhan, Nihan Haberal; Akdur, Aydincan; Kirnap, Mahir; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0001-9852-9911; https://orcid.org/0000-0002-8726-3369; https://orcid.org/0000-0002-3462-7632; X-8540-2019; AAE-1041-2021; AAK-4587-2021; AAA-3068-2021; AAH-9198-2019; AAJ-8097-2021
Baskent University Expanded Criteria for Hepatocellular Carcinoma: The Importance of the Histopathological Features as a Part of the Evaluation Criteria for Liver Transplantation
(2018) Ozgun, Gonca; Ozdemir, B. Handan; Moray, Gokhan; Reyhan, Nihan Haberal; Akdur, Aydincan; Kirnap, Mahir; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0003-2498-7287; 0000-0001-9852-9911; 0000-0002-8726-3369; 0000-0002-3462-7632; X-8540-2019; AAE-1041-2021; AAK-4587-2021; AAA-3068-2021; AAH-9198-2019; AAJ-8097-2021
The Beneficial Impact of D3 Vitamin on the Decline of Rejection, Epithelial-Mesenchymal Transition (EMT), And Interstitial Fibrosis Among Pediatric Renal Transplant Patients
(2022) Akcay, Eda Yilmaz; Ozdemir, B. Handan; Baskin, Esra; Ozdemir, F. Nurhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0001-6831-9585; AAJ-8097-2021; AAK-1960-2021
Bone Marrow Biopsy in Patients With Renal Transplant: Spectrum of Findings and Diagnostic Use
(2015) Borcek, Pelin; Ozdemir, B. Handan; Ozkan, Eylem Akar; Taslica, F. Zeynep; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-3462-7632; 25894168; X-8540-2019; AAJ-8097-2021
Objectives: Renal transplant may be complicated by cytopenia, fever of unknown etiology, or hematolymphoid malignancies. Bone marrow biopsy may be indicated to evaluate these complications. However, to the best of our knowledge, no previous study has systematically documented the characteristics of bone marrow biopsy in these patients. The present study reports the range of bone marrow findings in renal transplant recipients. Materials and Methods: We selected 85 patients who underwent bone marrow biopsy among 1745 renal transplant recipients who had transplant at Baskent University from January 1990 to December 2013. The files of these patients were reviewed for age, sex, age at renal transplant, underlying renal disease, donor type, immunosuppressive therapy, presence or absence of acute humoral or cellular rejection, duration between transplant and bone marrow biopsy, indication for bone marrow biopsy, and histopathologic diagnoses of bone marrow biopsies. Results: The most common cause of renal insufficiency leading to transplant in this patient group was unknown etiology, observed in 24 patients (28.2%). The most common indication for bone marrow biopsy was blood cytopenia, detected in 56 patients (65.9%). Neoplastic involvement of the bone marrow was detected in 6 patients (7.1%), all of which were hematolymphoid malignancies. Corticosteroids were the most commonly used immunosuppressive agents, administered to all patients. Conclusions: Bone marrow biopsy provides important information in renal transplant recipients, especially in cases of neoplastic bone marrow involvement, specific inflammation, and amyloidosis, which are uncommon in this patient group. The overall diagnostic use is related to the individual situation of each patient.
Bone Marrow Involvement by Lymphoproliferative Disorders After Solid-Organ Transplant
(2015) Ozkan, Eylem Akar; Ozdemir, B. Handan; Akcay, Eda Yilmaz; Terzi, Aysen; Karakus, Sema; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-1225-1320; 0000-0001-6831-9585; 0000-0002-3462-7632; 0000-0001-7615-4581; 25894151; X-8540-2019; F-7546-2013; AAK-1960-2021; AAJ-8097-2021; W-9092-2019
Objectives: Posttransplant lymphoproliferative disorders are classified as monomorphic, polymorphic, early lesions, or Hodgkin lymphoma. Bone marrow staging examination is recommended in posttransplant lymphoproliferative disorder patients. However, information about bone marrow involvement in these disorders is scarce. We evaluated 19 transplant patients with posttransplant lymphoproliferative disorder to investigate incidence of bone marrow involvement, associated morphologic changes, and prognosis. Materials and Methods: We retrospectively assessed bone marrow findings of 19 transplant patients with posttransplant lymphoproliferative disorder who underwent bone marrow staging at Baskent University from 1985 to 2013. Clinical and pathologic data were reviewed from the medical records. Follow-up information was obtained from medical records or communication with patients or families. Data collected including age, sex, Epstein-Barr virus status, immunosuppressive therapy, elapsed time from transplant to diagnosis of posttransplant lymphoproliferative disorder, B symptoms, number of extranodal sites, involvement of different organs, Ann Arbor clinical staging, hematologic parameters, and serum lactate dehydrogenase levels. Results: There were 5 of 19 patients (26.3%) who had bone marrow involvement with posttransplant lymphoproliferative disorder, including 2 patients diagnosed with posttransplant lymphoproliferative disorder by lymph node biopsy and 1 patient each diagnosed by native liver biopsy, nasopharyngeal biopsy, or allograft liver biopsy. In 4 patients, there was monomorphic posttransplant lymphoproliferative disorder subtype and 1 patient had early lesion posttransplant lymphoproliferative disorder subtype. In 10 of 19 patients (52.6%), Epstein-Barr virus was detected with in situ hybridization, including 3 patients with bone marrow involvement who were diagnosed with Burkitt lymphoma (n = 1), diffuse large B-cell lymphoma (n = 1), or early lesion (n = 1). Conclusions: Patients with posttransplant lymphoproliferative disorder have high incidence of bone marrow involvement and high mortality rates. Therefore, bone marrow examination may be important in the diagnosis and staging evaluation of posttransplant lymphoproliferative disorder.
Burkitt Lymphoma After Transplant: An Aggressive Lymphoproliferative Disease
(2014) Ozkan, Eylem Akar; Ozdemir, B. Handan; Akdur, Aydincan; Deniz, E. Ebru; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0002-8726-3369; 24635811; X-8540-2019; AAA-3068-2021
Posttransplant lymphoproliferative disorder (Burkitt lymphoma) may occur after liver transplant. A 3.5-year-old boy who was 17 months after liver transplant developed multiple millimeter-sized nodular lesions in the liver. Before transplant, the patient tested seronegative for Epstein-Barr virus; within 1 month after transplant, he tested seropositive for Epstein-Barr virus (1000 copies). Biopsy of the liver nodules showed posttransplant lymphoproliferative disorder (Burkitt lymphoma). Tacrolimus was stopped, sirolimus was started, and the patient was treated with chemotherapy (etoposide, doxorubicin, cyclophosphamide, corticosteroids and intrathecal methotrexate). Remission was achieved, and follow-up at 76 months after transplant showed no recurrence of the posttransplant lymphoproliferative disorder. In conclusion, posttransplant lymphoproliferative disorder (Burkitt lymphoma) may occur after liver transplant, and monitoring Epstein-Barr virus level may helpful after transplant because of the association between Epstein-Barr virus and Burkitt lymphoma.
A Case of Cerebral Tuberculosis After Liver Transplant and Literature Review
(2014) Tunca, M. Zeyneb; Akcay, Eda Yilmaz; Moray, Gokhan; Ozen, Ozlem; Ozdemir, B. Handan; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-9082-1317; https://orcid.org/0000-0002-7528-3557; 24635807; AAK-1960-2021; AAE-1041-2021; AAK-4468-2021; X-8540-2019
The risk of active tuberculosis is high in solid-organ recipients. We evaluated the clinical presentation of tuberculosis. Pulmonary locations were the most frequent, and extrapulmonary locations were rarely seen. Among extrapulmonary sites, intracranial tuberculosis is rare, with a few case reports reported in the literature. We report a case of 27-year-old man, who received deceased-donor liver transplant due to hepatitis B virus-related chronic liver failure. One month after the liver transplant, neurologic symptoms developed, then he had attacks of tonicclonic convulsions. Cerebral stereotactic needle biopsy of left temporal lobe was performed. Histopathologically gliosis, rare lymphocyte infiltration, and epithelioid histiocytes were seen. Histochemical staining by Ziehl Neelsen stain noted acid-fast resistant bacillus. The case was diagnosed as granulomatous inflammation which led to tuberculosis. In addition to antituberculosis therapy, he was given antiviral therapy for prophylaxis. During therapy, reactivation of hepatitis B virus was noted, and the recurrent diseases of hepatitis B virus-related viral hepatitis was diagnosed on serial biopsies. Ten months after transplant, he died from liver failure. Tuberculosis is a serious opportunistic infection in transplant recipients. The incidence of transplant recipients worldwide ranges from 0.35% to 15%. In nonrenal transplant, rejection within 6 months before the onset of tuberculosis and type of primary immunosuppressive regimen were predictors of tuberculosis infection occurring 12 months after transplant. The diagnosis and effective management of tuberculosis after transplant warnings recognition of the epidemiologic and clinical characteristics of tuberculosis in transplant recipients.
CLINICAL IMPACT OF COMPLEMENT DEPOSITION FINDINGS ON BIOPSIES IN ACUTE REJECTION EPISODES OF PEDIATRIC RENAL TRANSPLANT PATIENTS
(2020) Gulleroglu, Kaan; Baskin, Esra; Ozdemir, B. Handan; Yilmaz, Aysun Caltik; Soy, Ebru H. Ayvazoglu; Moray, Gokhan; Haberal, Mehmet A.
Comparison of Pediatric Patients with Pure Antibody-Mediated Rejection (Amr) and Recipients with Both Amr and Vascular Rejection in the Development of Interstitial Fibrosis and Transplant Glomerulopathy
(2017) Ozdemir, B. Handan; Ayva, S.; Baskin, E.; Ozdemir, F. Nurhan; Moray, G.; Haberal, M.; 0000-0002-7528-3557; 0000-0002-2280-8778; 0000-0003-4361-8508; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; AAK-1967-2021; B-5785-2018; AAE-1041-2021; AAJ-8097-2021
COMPARISON OF PURE ANTIBODY-MEDIATED REJECTION (AMR) WITH MIXED CELLULAR AND AMR IN REGARDS TO THE DEVELOPMENT OF CARDIAC ALLOGRAFT VASCULOPATHY (CAV) AND CARDIOVASCULAR MORTALITY (CVM) IN HEART TRANSPLANT PATIENTS
(2019) Ozdemir, B. Handan; Ayva, Sebnem; Terzi, Aysen; Sade, L. Elif; Basturk, Bilkay; Sezgin, Atilla
COMPARISON OF PURE ANTIBODY-MEDIATED REJECTION WITH MIXED CELLULAR AND ANTIBODY-MEDIATED REJECTION IN REGARDS TO THE PATHOLOGICAL FEATURES, DEVELOPMENT OF CARDIAC ALLOGRAFT VASCULOPATHY (CAV) AND CARDIOVASCULAR MORTALITY (CVM) IN HEART TRANSPLANT PATIENTS
(2020) Ozdemir, B. Handan; Terzi, Aysen; Ayva, Sebnem; Sade, L. Elif; Basturk, Bilkay; Sezgin, Atilla
COMPARISON OF RAPAMYCIN WITH CYCLOSPORIN, AND TACROLIMUS IN REGARDS TO THE DEVELOPMENT OF EPITHELIAL-TO-MESENCHYMAL TRANSITION (EMT) OF TUBULAR CELLS AND ENDOTHELIAL-TO-MESENCHYMAL TRANSITION (ENDOMT) OF PERITUBULAR CAPILLARIES (PTCS)
(2020) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Atilgan, Alev Ok; Akcay, Eda; Polat, Aysegul Yucel; Akdur, Aydincan; Haberal, Mehmet A.
Comparison of Recipients with Early and Later Presentation Polyomavirus Nephropathy (PVN) with Regard to Histological Findings and Graft Survival: What is the Influence of CD4/CD8 Ration on the Presenting Time of PVN
(2018) Ozdemir, B. Handan; Ayva, Sebnem; Terzi, Aysen; Atilgan, Alev Ok; Akcay, Eda; Soy, Ebru H. Ayvazoglu; Acar, F. Nurhan Ozdemir; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-2280-8778; 0000-0002-1225-1320; 0000-0001-8595-8880; 0000-0001-6831-9585; 0000-0002-0993-9917; 0000-0002-5682-0943; 0000-0002-3462-7632; X-8540-2019; AAK-1967-2021; F-7546-2013; AAK-3333-2021; AAK-1960-2021; AAC-5566-2019; AAK-1697-2021; AAJ-8097-2021
CYTOMEGALOVIRUS (CMV) INFECTION INDUCES AN ANGIOGENIC RESPONSE THROUGH HEPATIC STELLATE CELLS (HSCS) AND LEADS TO EARLY POST-TRANSPLANT LIVER FIBROSIS (LF) AND POOR GRAFT SURVIVAL
(2019) Ozdemir, B. Handan; Ozgun, Gonca; Soy, Ebru H. Ayvazoglu; Haberal, Nihan; Moray, Gokhan; Haberal, Mehmet; 0000-0002-0993-9917; AAC-5566-2019
Cytomegalovirus Infection Induces an Angiogenic Response through Hepatic Stellate Cells and Leads to Early Post-Transplant Liver Fibrosis and Poor Graft Survival
(2019) Ozdemir, B. Handan; Ozgun, Gonca; Soy, Ebru H. Ayvazoglu; Haberal, Nihan; Moray, Gokhan; Haberal, Mehmet A.
Detection of Donor-Specific Antibodies Both in Serum and Cardiac Allograft Biopsy in Heart Transplant Patients: Tissue DSA is More Predictive than Serum DSA
(2018) Basturk, Bilkay; Sezgin, Atilla; Sade, Elif; Ozdemir, B. Handan; Terzi, Aysen; Kantaroglu, Bircan; Haberal, Mehmet; 0000-0002-8784-1974; 0000-0002-7528-3557; 0000-0002-1225-1320; 0000-0002-3462-7632; AAD-6918-2021; X-8540-2019; F-7546-2013; AAJ-8097-2021
Development of Transplant Glomerulopathy in Recipients with Antibody Mediated Rejection: Activation of Inflammatory Pathway Through Renal Poly (Adp-Ribose) Polymerase (Parp)
(2017) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Baski, N. Esra; Moray, Gokhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; AAE-1041-2021; AAJ-8097-2021
Divergent Role of Programmed Death -Ligand 1 (PD-L1) in Renal Allografts with Antibody-Mediated Rejection (AMR)
(2018) Ozdemir, B. Handan; Akcay, Eda; Atilgan, Alev Ok; Borcek, Pelin; Tepeoglu, Merih; Polat, Aysegul Yucel; Deniz, Melis; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0001-8595-8880; https://orcid.org/0000-0002-9894-8005; https://orcid.org/0000-0002-3590-9375; AAJ-8097-2021; X-8540-2019; AAK-1960-2021; AAK-3333-2021; AAK-5222-2021; AAP-3975-2021; https://orcid.org/0000-0002-3462-7632