Fertility preservation in early-stage endometrial cancer and endometrial intraepithelial neoplasia: A single-center experience
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Tarih
2020Yazar
Ayhan, Ali
Tohma, Yusuf Aytac
Tunc, Mehmet
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Objective: The purpose of this study was to define the pregnancy and oncologic outcomes after fertility-sparing treatment of atypical hyperplasia (AH)/endometrial intraepithelial neoplasia (EIN) and early-stage endometrioid endometrial cancer (EEC).
Materials and methods: The retrospective cohort study included patients who had applied to Baskent University's Ankara Hospital between January 2007 and October 2018 with either AH/EIN (n: 27; Group A) or EEC (n: 30; Group B), and who had the desire to preserve their fertility. The medical records of all patients included in the study were reviewed retrospectively from the hospital records.
Results: There were 2 (7.4%) and 5 (16.7%) recurrences, whereby one patient from Group A and two patients from Group B underwent staging surgery. In Group A, 8 patients attempted pregnancy after their treatment and 4 of them (50%) became pregnant, while 3 of them (37.5%) had a live birth. In Group B, there were 17 patients who wanted to become pregnant following treatment of the disease; 8 of them (47%) became pregnant after treatment, 5 of them (16.6%) had a live birth, 1 experienced intrauterine exitus (at 21st gestational week, 350 g), and 2 currently have ongoing pregnancies.
Conclusion: Hysteroscopic resection of visible lesions and full endometrial curettage prior to hormonal therapy as a fertility-preserving approach for women of reproductive age with endometrial malignancies can achieve promising oncologic and obstetric responses. (C) 2020 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
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https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1028455920300644?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1028455920300644%3Fshowall%3Dtrue&referrer=https:%2F%2Fapps.webofknowledge.com%2Fhttp://hdl.handle.net/11727/6065