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dc.contributor.authorCaglar, Omur
dc.contributor.authorTokgozoglu, Mazhar
dc.contributor.authorAkgun, Rahmi C.
dc.contributor.authorAtilla, Bulent
dc.date.accessioned2021-04-29T07:45:15Z
dc.date.available2021-04-29T07:45:15Z
dc.date.issued2020
dc.identifier.issn2687-4784en_US
dc.identifier.urihttps://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=E3V5riSPiJ4L6X6DkYx&page=7&doc=323
dc.identifier.urihttp://hdl.handle.net/11727/5817
dc.description.abstractObjectives: This study aims to evaluate the success rate in terms of eradication of infection and long-term outcomes of two-stage revision arthroplasty with spacers loaded with low-dose vancomycin alone for the treatment of an infected hip arthroplasty. Patients and methods: The records of 42 two-stage exchange arthroplasty patients (16 males. 26 females; mean age 61 years: range, 30 to 80 years) treated between January 1999 and January 2009 were included in this retrospective study. In the first stage. following removal of the prosthesis and debridement, a spacer consisting of 1 g of vancomycin per 40 g of cement was placed in the infected joint space. Patients received six weeks of intravenous antibiotics according to intraoperative cultures. After cessation of systemic antibiotic treatment, with normal C-reactive protein and erythrocyte sedimentation rate levels, second stage surgery with cementless components was performed. Results: The mean follow-up duration was seven (range, 3 to 13) years. Two patients (4.7%) developed re-infection after two-stage reimplantation and one patient underwent a resection arthroplasty after repeated debridements. Five years of survival was 92.9% with Kaplan-Meier survival analysis. Conclusion: For chronic infected total hip revisions, two-stage revision arthroplasty with low-dose vancomycin impregnated cement spacers have comparable re-infection and success rates. Low-dose vancomycin promotes effective infection control and reduces antibiotic toxicity.en_US
dc.language.isoengen_US
dc.relation.isversionof10.5606/ehc.2020.76108en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibiotic-loaded cement spaceren_US
dc.subjectperiprosthetic infection of the hipen_US
dc.subjecttwo-stage revisionen_US
dc.subjectvancomycinen_US
dc.titleLow-dose vancomycin-loaded cement spacer for two-stage revision of infected total hip arthroplastyen_US
dc.typearticleen_US
dc.relation.journalJOINT DISEASES AND RELATED SURGERYen_US
dc.identifier.volume31en_US
dc.identifier.issue3en_US
dc.identifier.startpage449en_US
dc.identifier.endpage455en_US
dc.identifier.wos000573941100007en_US
dc.identifier.scopus2-s2.0-85091566861en_US
dc.contributor.pubmedID32962574en_US
dc.contributor.orcID0000-0002-7545-1784en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAJ-4335-2021en_US


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