dc.contributor.author | Caglar, Omur | |
dc.contributor.author | Tokgozoglu, Mazhar | |
dc.contributor.author | Akgun, Rahmi C. | |
dc.contributor.author | Atilla, Bulent | |
dc.date.accessioned | 2021-04-29T07:45:15Z | |
dc.date.available | 2021-04-29T07:45:15Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2687-4784 | en_US |
dc.identifier.uri | https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=E3V5riSPiJ4L6X6DkYx&page=7&doc=323 | |
dc.identifier.uri | http://hdl.handle.net/11727/5817 | |
dc.description.abstract | Objectives: This study aims to evaluate the success rate in terms of eradication of infection and long-term outcomes of two-stage revision arthroplasty with spacers loaded with low-dose vancomycin alone for the treatment of an infected hip arthroplasty.
Patients and methods: The records of 42 two-stage exchange arthroplasty patients (16 males. 26 females; mean age 61 years: range, 30 to 80 years) treated between January 1999 and January 2009 were included in this retrospective study. In the first stage. following removal of the prosthesis and debridement, a spacer consisting of 1 g of vancomycin per 40 g of cement was placed in the infected joint space. Patients received six weeks of intravenous antibiotics according to intraoperative cultures. After cessation of systemic antibiotic treatment, with normal C-reactive protein and erythrocyte sedimentation rate levels, second stage surgery with cementless components was performed.
Results: The mean follow-up duration was seven (range, 3 to 13) years. Two patients (4.7%) developed re-infection after two-stage reimplantation and one patient underwent a resection arthroplasty after repeated debridements. Five years of survival was 92.9% with Kaplan-Meier survival analysis.
Conclusion: For chronic infected total hip revisions, two-stage revision arthroplasty with low-dose vancomycin impregnated cement spacers have comparable re-infection and success rates. Low-dose vancomycin promotes effective infection control and reduces antibiotic toxicity. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.5606/ehc.2020.76108 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antibiotic-loaded cement spacer | en_US |
dc.subject | periprosthetic infection of the hip | en_US |
dc.subject | two-stage revision | en_US |
dc.subject | vancomycin | en_US |
dc.title | Low-dose vancomycin-loaded cement spacer for two-stage revision of infected total hip arthroplasty | en_US |
dc.type | article | en_US |
dc.relation.journal | JOINT DISEASES AND RELATED SURGERY | en_US |
dc.identifier.volume | 31 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 449 | en_US |
dc.identifier.endpage | 455 | en_US |
dc.identifier.wos | 000573941100007 | en_US |
dc.identifier.scopus | 2-s2.0-85091566861 | en_US |
dc.contributor.pubmedID | 32962574 | en_US |
dc.contributor.orcID | 0000-0002-7545-1784 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.contributor.researcherID | AAJ-4335-2021 | en_US |