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dc.contributor.authorAytan, Pelin
dc.contributor.authorKocer, Nazim Emrah
dc.contributor.authorYeral, Mahmut
dc.contributor.authorGereklioglu, Cigdem
dc.contributor.authorKasar, Mutlu
dc.contributor.authorBuyukkurt, Nur Hilal
dc.contributor.authorAsma, Suheyl
dc.contributor.authorOzdogu, Hakan
dc.contributor.authorBoga, Can
dc.date.accessioned2020-07-16T12:10:12Z
dc.date.available2020-07-16T12:10:12Z
dc.date.issued2019
dc.identifier.issn1306-133Xen_US
dc.identifier.urihttp://www.uhod.org/pdf/PDF_824.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4767
dc.description.abstractThe aim of this study is to assess the cases of nonhematologic maiignancies that had bone marrow (BM) metastasis with respect to hematologic abnormalities, radiologic findings and pathologic findings. All of the patients with BM investigation were retrospectively evaluated. The patients with BM metastasis by a non-hematologic malignancy were assessed. Data regarding patient characteristics including peripheral blood evaluation findings, imaging findings, BM evaluation results and survival were obtained from patient files and computer based electronic database. 30 cases were detected among 1831 BM aspirations and biopsies. The most common malignancies were breast (36.7%), prostate (13.3%), gastric(13.3%) and lung (13.3%) adenocarcinomas. 90.9% and 75% of the cases had positive radiologic findings with PET/CT and CT respectively. 43.3% of the patients died during the study period and the median time from BM assessment to death was 2 months. Anemia, thrombocytopenia and leukopenia were present in 90%, 73.3% and 20% respectively. Lactate dehydrogenase and alkaline phosphatase were elevated in 90% and 80% respectively. In 76.2% a leukoerythroblastic blood picture was present. All the cases were diagnosed with biopsy and aspiration detected infiltration in 40% and in 4 metastatic patients (13.3%) the aspiration was false negative. In 46.7% the aspiration resulted with dry tap. Grade 3 fibrosis was present in 76.7%. BM assessment is a minimally invasive technique and provides very beneficial clinical data, however, because the survival is very short after BM assessment and the PET/CT has a considerable sensitivity it is not necessary to confirm BM metastasis in patients whose tumor stage is already known.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4999/uhod.193682en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-hematologic malignancyen_US
dc.subjectBone marrowen_US
dc.subjectBiopsyen_US
dc.subjectAspirationen_US
dc.titleNon-Hematologic Malignancies Metastasing to the Bone Marrow: A Record-Based Descriptive Study From A Tertiary Centeren_US
dc.typearticleen_US
dc.relation.journalUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.identifier.volume29en_US
dc.identifier.issue4en_US
dc.identifier.startpage238en_US
dc.identifier.endpage245en_US
dc.identifier.wos000506006500006en_US
dc.identifier.scopus2-s2.0-85078253789en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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