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dc.contributor.authorSolmaz, Soner
dc.contributor.authorGokbulut, Aysun Adan
dc.contributor.authorCincin, Birsu
dc.contributor.authorOzdogu, Hakan
dc.contributor.authorBoga, Can
dc.contributor.authorCakmakoglu, Bedia
dc.contributor.authorKozanoglu, Ilknur
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2019-12-21T15:22:16Z
dc.date.available2019-12-21T15:22:16Z
dc.date.issued2014
dc.identifier.issn0163-5581
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/01635581.2014.894099
dc.identifier.urihttp://hdl.handle.net/11727/4521
dc.description.abstractDespite the presence of many therapeutic regimens like imatinib and other tyrosine kinase inhibitors, the development of resistance, intolerance, and side effects makes chronic myeloid leukemia (CML) therapy challenging. Thus, there is a need to discover novel drugs for CML patients. In this study, we attempted to assess apigenin, a common plant dietary flavonoid, in terms of its cytotoxic, apoptotic, and cytostatic effects on imatinib-sensitive and resistant Philadelphia-positive CML cells. We analyzed apigenin's effects on cell proliferation, apoptosis, caspase-3 activity, loss of mitochondrial membrane potential, and cell cycle progression in K562 and K562/IMA3 cells. Furthermore, we described genes and gene networks that are modulated in CML in response to apigenin. Results of our study revealed that apigenin has cytotoxic and apoptotic effects on both cell types. We also displayed that apigenin induced G2/M arrest in K562 cells while arresting K562/IMA3 cells in S phase especially at the highest apigenin concentration. The expression analysis identified a set of genes that were regulated by apigenin in K652 and K562/IMA3 cells. Association of modulated genes with biological functional groups identified several networks affected by apigenin including cell survival, proliferation, cell death, cell cycle, and cell signalling pathways.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1080/01635581.2014.894099en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectINDUCED-APOPTOSISen_US
dc.subjectINDUCE APOPTOSISen_US
dc.subjectDRUG-RESISTANCEen_US
dc.subjectCYCLE ARRESTen_US
dc.subjectCANCERen_US
dc.subjectEXPRESSIONen_US
dc.subjectIDENTIFICATIONen_US
dc.subjectMODULATIONen_US
dc.subjectACTIVATIONen_US
dc.subjectMECHANISMSen_US
dc.titleTherapeutic Potential of Apigenin, a Plant Flavonoid, for Imatinib-Sensitive and Resistant Chronic Myeloid Leukemia Cellsen_US
dc.typearticleen_US
dc.relation.journalNUTRITION AND CANCER-AN INTERNATIONAL JOURNALen_US
dc.identifier.volume66en_US
dc.identifier.issue4en_US
dc.identifier.startpage599en_US
dc.identifier.endpage612en_US
dc.identifier.wos000335214300008


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