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dc.contributor.authorAvci, Aynur Yilmaz
dc.contributor.authorLakadamyali, Hatice
dc.contributor.authorArikan, Serap
dc.contributor.authorBenli, Ulku Sibel
dc.contributor.authorKilinc, Munire
dc.date.accessioned2019-12-07T08:04:04Z
dc.date.available2019-12-07T08:04:04Z
dc.date.issued2015
dc.identifier.issn1129-2369
dc.identifier.urihttps://thejournalofheadacheandpain.biomedcentral.com/track/pdf/10.1186/1129-2377-16-9
dc.identifier.urihttp://hdl.handle.net/11727/4375
dc.description.abstractMigraine is a common headache disorder that may be associated with vascular disease and cerebral white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) scan. High sensitivity C-reactive protein (hs-CRP) is a marker of inflammation that may predict subclinical atherosclerosis. However, the relation between migraine, vascular risks, and WMHs is unknown. We evaluated hs-CRP levels and the relation between hs-CRP level and WMHs in adult migraine patients. This case-control study included 432 subjects (216 migraine patients [without aura, 143 patients; with aura, 73 patients]; 216 healthy control subjects without migraine; age range 18-50 y). Migraine diagnosis was determined according to the International Classification of Headache Disorders II diagnostic criteria. The migraine patients and control subjects had no known vascular risk factors, inflammatory disease, or comorbid disease. The presence and number of WMHs on MRI scans were determined, and serum hs-CRP levels were measured by latex-enhanced immunoturbidimetry. Mean hs-CRP level was significantly greater in migraine patients (1.94 +/- 2.03 mg/L) than control subjects (0.82 +/- 0.58 mg/L; P a parts per thousand currency signaEuro parts per thousand.0001). The mean number of WMHs per subject and the presence of WMHs was significantly greater in migraine patients (69 patients [31.9%]; 1.68 +/- 3.12 mg/dL) than control subjects (21 subjects [9.7%]; 0.3 +/- 1.3; P a parts per thousand currency signaEuro parts per thousand.001). However, there was no correlation between hs-CRP level and WMHs in migraine patients (r = 0.024; not significant). The presence of WMHs was increased 4.35-fold in migraine patients (odds ratio 4.35, P a parts per thousand currency signaEuro parts per thousand.001). High hs-CRP level may be a marker of the proinflammatory state in migraine patients. However, the absence of correlation between hs-CRP level and WMHs suggests that hs-CRP is not causally involved in the pathogenesis of WMHs in migraine patients. The WMHs were located mostly in the frontal lobe and subcortical area.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1186/1129-2377-16-9en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeadacheen_US
dc.subjectInflammationen_US
dc.subjectVascular diseaseen_US
dc.subjectPathophysiologyen_US
dc.titleHigh sensitivity C-reactive protein and cerebral white matter hyperintensities on magnetic resonance imaging in migraine patientsen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF HEADACHE AND PAINen_US
dc.identifier.volume16en_US
dc.identifier.startpage1en_US
dc.identifier.endpage10en_US
dc.identifier.wos000353841300001en_US
dc.identifier.scopus2-s2.0-84929493815en_US
dc.contributor.pubmedID25595197en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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